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hydrogels
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A review on catalytic reduction/degradation of organic pollution through silver-based hydrogels
, Article Arabian Journal of Chemistry ; Volume 15, Issue 9 , 2022 ; 18785352 (ISSN) ; Ali Ghasemzadeh, M ; Alipour, S ; Zamani, F ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Various challenging pollutants are produced in the environment by organic materials of diverse industries including leather, paint, and textile. Nowadays, it is vital to develop efficient manners regarding the fundamental issues and removing pollutants. Such pollutants can be effectively removed from the environment through heterogeneous catalysts. Recently, a huge deal of interest has been attracted by hydrogel-based metal catalysts as heterogeneous and efficient catalysts. In this regard, silver with its unique features is suitable for environmental remediation. Hence, the present review deals with summarizing the present advances in the synthesis of silver-based hydrogel catalysts, as...
Immunomodulating hydrogels as stealth platform for drug delivery applications
, Article Pharmaceutics ; Volume 14, Issue 10 , 2022 ; 19994923 (ISSN) ; Yilmaz Aykut, D ; Tourk, F. M ; Bassous, N ; Barroso Zuppa, M ; Shawl, A. I ; Ashraf, S. S ; Avci, H ; Hassan, S ; Sharif University of Technology
MDPI
2022
Abstract
Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on...
A smart tri-layered nanofibrous hydrogel thin film with controlled release of dual drugs for chemo-thermal therapy of breast cancer
, Article Journal of Drug Delivery Science and Technology ; Volume 76 , 2022 ; 17732247 (ISSN) ; Mohammadi Ziarani, G ; Badiei, A ; Pourjavadi, A ; Kiani, M ; Sharif University of Technology
Editions de Sante
2022
Abstract
A tri-layered nanofibrous hydrogel thin film with temperature sensitivity is introduced as a new controlled drug release system to treat breast cancer. A simultaneous heat generation with the tunable release of dual drugs is observed in response to visible light radiation. A tri-layered nanofibrous sheet was fabricated through sequential electrospinning the blends of Au@Chit@DOX-loaded poly(N-isopropylacrylamide-co-N-methylol acrylamide) (poly (NIPAAm-co-NMA)) and Curcumin-loaded poly (vinyl alcohol) (Cu-loaded PVA), where the Cu-loaded PVA nanofibers (NFs) are sandwiched between two layers of Au@Chit@DOX-loaded poly (NIPAAm-co-NMA) NFs. After thermal crosslinking of the tri-layered...
Customizing nano-chitosan for sustainable drug delivery
, Article Journal of Controlled Release ; Volume 350 , 2022 , Pages 175-192 ; 01683659 (ISSN) ; Vahidi, O ; Moghbeli, M ; Ahmadi, S ; Asadnia, M ; Akhavan, O ; Seidi, F ; Rabiee, M ; Saeb, M. R ; Webster, T. J ; Varma, R. S ; Sharifi, E ; Zarrabi, A ; Rabiee, N ; Sharif University of Technology
Elsevier B.V
2022
Abstract
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in...
Experimental evaluation of a solar-driven adsorption desalination system using solid adsorbent of silica gel and hydrogel
, Article Environmental Science and Pollution Research ; Volume 29, Issue 47 , 2022 , Pages 71217-71231 ; 09441344 (ISSN) ; Behshad Shafii, M ; Ebrahimpour, B ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Nowadays, the world is facing a shortage of fresh water. Utilizing adsorbent materials to adsorb air moisture is a suitable method for producing freshwater, especially combining the adsorption desalination system with solar energy devices such as solar collectors. The low temperature of solar collectors has caused some water to remain in the adsorbents in the desorption process and has reduced the possibility of using these systems. In this research, for the first time, an evacuated tube collector (ETC) is used as an adsorbent bed so that the temperature of the desorption process reaches higher values and as a result, more fresh water is expected to produced. In this study, two adsorption...
Development of injectable hydrogels based on human amniotic membrane and polyethyleneglycol-modified nanosilicates for tissue engineering applications
, Article European Polymer Journal ; Volume 179 , 2022 ; 00143057 (ISSN) ; Tamjid, E ; Niknejad, H ; Simchi, A ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Recently, decellularized amniotic membrane-derived hydrogels (DAMHs) have received significant attention for wound care, ocular surface reconstruction, and chondral healing. Despite the advantages of DAMHs for tissue engineering (TE), the loss of structural components during the decellularization process mitigates their mechanical strength and thus limits their practical application. Herein, we present a method for the surface modification of two-dimensional nanosilicates (laponite) as a rheological modifier to tailor the properties of DAMHs. Results show that after introducing nanosilicates, severe aggregation of the nanoparticles occurs, owing to the shielding effect of ions on the surface...
Water treatment using stimuli-responsive polymers
, Article Polymer Chemistry ; Volume 13, Issue 42 , 2022 , Pages 5940-5964 ; 17599954 (ISSN) ; Roghani Mamaqani, H ; Riazi, H ; Abousalman Rezvani, O ; Sharif University of Technology
Royal Society of Chemistry
2022
Abstract
Water treatment is a process used to eliminate or reduce chemical and biological contaminants that are potentially harmful to the water supply for human use. Stimuli-responsive polymers are a new category of smart materials used in water treatment via a stimuli-induced purification process and subsequent regeneration of the polymers. Stimuli-responsive polymers dynamically change their physico-chemical properties upon environmental changes. They can undergo shrinkage or expansion, alter their optical properties, and change their electrical characteristics depending on the applied stimuli. In this context, various stimuli-responsive polymer systems such as self-assembled nanostructures,...
Adsorption properties of halloysite modified acrylamide/quince seeds-based hydrogel: Experimental and DFT investigation
, Article Journal of Polymers and the Environment ; Volume 30, Issue 11 , 2022 , Pages 4637-4650 ; 15662543 (ISSN) ; Mirzaee Valadi, F ; Akbarzadeh, E ; Gholami, M. R ; Sharif University of Technology
Springer
2022
Abstract
In this work Halloysite nanotubes were used to synthesis a series of modified acrylamide/Quince seeds-based hydrogels (Poly (AAm-co-QS)/Haln). The as-prepared Poly (AAm-co-QS)/Haln hydrogels displayed improved performance as adsorbent in elimination of methylene blue (MB) from aqueous solution. The structures of the prepared Poly (AAm-co-QS)/Haln hydrogels were identified by XRD, FT-IR, FE-SEM, BET, TGA and EDX. Effect of pH value on the swelling behavior and dye adsorption performance of as-prepared hydrogels was explored. The adsorption MB results suggested that the adsorption kinetics fitted the pseudo-second-order model. The adsorption experiments at various pH condition indicated that...
Comparison of engineered cartilage based on BMSCs and chondrocytes seeded on PVA-PPU scaffold in a sheep model
, Article Journal of Biomedical Materials Research - Part B Applied Biomaterials ; Volume 110, Issue 11 , 2022 , Pages 2411-2421 ; 15524973 (ISSN) ; Sepahdar, A ; Rabiee, N ; Nazbar, A ; Farzad Mohajeri, S ; Dehghan, M. M ; Shokrgozar, M. A ; Majidi, M ; Mardjanmehr, S. H ; Aminianfar, H ; Akbari Javar, H ; Bonakdar, S ; Sharif University of Technology
John Wiley and Sons Inc
2022
Abstract
In this study, polyvinyl alcohol hydrogel chains were crosslinked by polyurethane in order to synthesize a suitable substrate for cartilage lesions. The substrate was fully characterized, and in vitro and in vivo investigations were conducted based on a sheep model. In vitro tests were performed based on the chondrocyte cells with the Alcian Blue and safranin O staining in order to prove the presence of proteoglycan on the surface of the synthesized substrate, which has been secreted by cultures of chondrocytes. Furthermore, the expression of collagen type I, collagen type II, aggrecan, and Sox9 was presented in the chondrocyte cultures on the synthesized substrate through RT-PCR. In...
Additive manufacturing of bioactive glass biomaterials
, Article Methods ; Volume 208 , 2022 , Pages 75-91 ; 10462023 (ISSN) ; Alasvand, N ; Khodadadi, M ; Ghobadi, F ; Malekzadeh Kebria, M ; Brouki Milan, P ; Kargozar, S ; Baino, F ; Mobasheri, A ; Mozafari, M ; Sharif University of Technology
Academic Press Inc
2022
Abstract
Tissue engineering (TE) and regenerative medicine have held great promises for the repair and regeneration of damaged tissues and organs. Additive manufacturing has recently appeared as a versatile technology in TE strategies that enables the production of objects through layered printing. By applying 3D printing and bioprinting, it is now possible to make tissue-engineered constructs according to desired thickness, shape, and size that resemble the native structure of lost tissues. Up to now, several organic and inorganic materials were used as raw materials for 3D printing; bioactive glasses (BGs) are among the most hopeful substances regarding their excellent properties (e.g., bioactivity...
Efficient wound healing by antibacterial property: Advances and trends of hydrogels, hydrogel-metal NP composites and photothermal therapy platforms
, Article Journal of Drug Delivery Science and Technology ; Volume 73 , 2022 ; 17732247 (ISSN) ; Gheybi, H ; Adeli, M ; Sharif University of Technology
Editions de Sante
2022
Abstract
Bacterial infection is one of the biggest challenges in wound healing and imposes enormous burden on patient and medical system. Moreover, multidrug resistant microorganisms (MDR) limit the usage of therapeutic agents including antibiotics for wound treatment. Hydrogels are three-dimensional networks that have emerged as efficient scaffolds for the treatment of infected wounds. In addition to their intrinsic antibacterial activities, hydrogels are able to load and release therapeutic agents to keep the efficient dose during wound healing process. At the same lines, incorporation of metal nanoparticles (NPs) into hydrogels boosts their antibacterial activity. Moreover, photothermal agents...
Developing tough terpolymer hydrogel with outstanding swelling ability by hydrophobic association cross-linking
, Article Polymer ; Volume 254 , 2022 ; 00323861 (ISSN) ; Shojaei, A ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Hydrogels with remarkable hydrophilicity and tunable toughness are appealing materials to serve as superabsorbent polymers. However, chemically cross-linked hydrogels often suffer from low toughness regardless of their considerable swelling, restricting their widespread applications. In comparison, the network of physically cross-linked hydrogels can be regulated to meet both a high swelling ratio and considerable toughness. Here, we develop superabsorbent and tough hydrophobic associated hydrogels using terpolymerization of poly acrylic acid (PAA), polyacrylamide (PAM), and lauryl methacrylate (LMA) within the micelles formed by sodium dodecyl sulfate (SDS) surfactant. To this end, various...
An electroconductive, thermosensitive, and injectable chitosan/pluronic/gold-decorated cellulose nanofiber hydrogel as an efficient carrier for regeneration of cardiac tissue
, Article Materials ; Volume 15, Issue 15 , 2022 ; 19961944 (ISSN) ; Maleki Jirsaraei, N ; Simchi, A ; Mohandes, F ; Emami, Z ; Fassina, L ; Naro, F ; Conti, B ; Barbagallo, F ; Sharif University of Technology
MDPI
2022
Abstract
Myocardial infarction is a major cause of death worldwide and remains a social and healthcare burden. Injectable hydrogels with the ability to locally deliver drugs or cells to the damaged area can revolutionize the treatment of heart diseases. Herein, we formulate a thermo-responsive and injectable hydrogel based on conjugated chitosan/poloxamers for cardiac repair. To tailor the mechanical properties and electrical signal transmission, gold nanoparticles (AuNPs) with an average diameter of 50 nm were physically bonded to oxidized bacterial nanocellulose fibers (OBC) and added to the thermosensitive hydrogel at the ratio of 1% w/v. The prepared hydrogels have a porous structure with open...
Simulations of extrusion 3d printing of chitosan hydrogels
, Article Applied Sciences (Switzerland) ; Volume 12, Issue 15 , 2022 ; 20763417 (ISSN) ; Mohammad Mirjamali, S ; He, Y ; Sharif University of Technology
MDPI
2022
Abstract
Extrusion-based three-dimensional (3D) printing has recently become a major field that provides significant benefits, as it is principally employed to fabricate 3D scaffolds, exploiting soft biomaterials. The 3D printing hydrogel-based ink requires crucial properties, such as printability and printing fidelity to fabricate the appropriate structure. However, it typically uses trial and error techniques to achieve a three-dimensional structure, which wastes material and time. This study employed multiphysics simulation to predicate the potential printability of chitosan hydrogel as a desirable biomaterial used in tissue engineering. The flow was presumed to be laminar and two-phased in the...
Magnetic carboxymethyl cellulose/silk fibroin hydrogel embedded with halloysite nanotubes as a biocompatible nanobiocomposite with hyperthermia application
, Article Materials Chemistry and Physics ; Volume 287 , 2022 ; 02540584 (ISSN) ; Choopani, L ; Aghamirza Moghim Aliabadi, H ; Ganjali, F ; Kashtiaray, A ; Maleki, A ; Ahangari Cohan, R ; Salimi Bani, M ; Komijani, S ; Ahadian, M. M ; Salehpour, N ; Mahdavi, M ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
A novel and high potent magnetic nanobiocomposite was prepared based on Carboxymethyl cellulose (CMC) and epichlorohydrin (ECH) cross-linker interactions to form a three-dimensional cross-linked CMC hydrogel followed by silk fibroin (SF) and halloysite nanotubes (HNTs) modifications and further in situ Fe3O4 magnetic nanoparticles (MNPs) formation. Different analytical techniques like FT-IR, EDX, FE-SEM, XRD, TGA, and VSM were used to characterize the structure of the prepared nanobiocomposite. The spherical morphology of Fe3O4 MNPs and tubular HNTs were presented in the FE-SEM images. In biological tests, since the hemolysis percent was even less than the negative control, the CMC...
Gold nanorods for drug and gene delivery: An overview of recent advancements
, Article Pharmaceutics ; Volume 14, Issue 3 , 2022 ; 19994923 (ISSN) ; Mousazadeh, M ; Taji, S ; Bahmani, A ; Zarepour, A ; Zarrabi, A ; Sharifi, E ; Azimzadeh, M ; Sharif University of Technology
MDPI
2022
Abstract
Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both...
Polymer/metal composite 3D porous bone tissue engineering scaffolds fabricated by additive manufacturing techniques: A review
, Article Bioprinting ; Volume 25 , 2022 ; 24058866 (ISSN) ; Bakhshi, R ; Alizadeh, R ; Sharif University of Technology
Elsevier B.V
2022
Abstract
The employment of tissue engineering scaffolds in the reconstruction of the damaged bone tissues has shown remarkable promise since they significantly facilitate the healing process. Fabrication of highly porous biocompatible scaffolds with sufficient mechanical strength is still challenging. In this regard, polymers have been widely utilized to construct three-dimensional (3D) porous scaffolds due to their excellent processability and biocompatibility. However, insufficient mechanical strength and inappropriate degradation rate of the monophasic polymer scaffolds in the bone regeneration process, as the main challenges, limit their extensive clinical application. The incorporation of...
Unraveling cancer metastatic cascade using microfluidics-based technologies
, Article Biophysical Reviews ; Volume 14, Issue 2 , 2022 , Pages 517-543 ; 18672450 (ISSN) ; Kermanshah, L ; Abouali, H ; Hashemi, H. M ; Yari, A ; Khorasheh, F ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
Springer Science and Business Media Deutschland GmbH
2022
Abstract
Cancer has long been a leading cause of death. The primary tumor, however, is not the main cause of death in more than 90% of cases. It is the complex process of metastasis that makes cancer deadly. The invasion metastasis cascade is the multi-step biological process of cancer cell dissemination to distant organ sites and adaptation to the new microenvironment site. Unraveling the metastasis process can provide great insight into cancer death prevention or even treatment. Microfluidics is a promising platform, that provides a wide range of applications in metastasis-related investigations. Cell culture microfluidic technologies for in vitro modeling of cancer tissues with fluid flow and the...
A dual functional chondro-inductive chitosan thermogel with high shear modulus and sustained drug release for cartilage tissue engineering
, Article International Journal of Biological Macromolecules ; Volume 205 , 2022 , Pages 638-650 ; 01418130 (ISSN) ; Mehrjou, B ; Wang, D ; Bagheri, R ; Solouk, A ; Chu, P. K ; Wu, H ; Sharif University of Technology
Elsevier B.V
2022
Abstract
We report a chitosan-based nanocomposite thermogel with superior shear modulus resembling that of cartilage and dual pro-chondrogenic and anti-inflammatory functions. Two therapeutic agents, kartogenin (KGN) and diclofenac sodium (DS), are employed to promote chondrogenesis of stem cells and suppress inflammation, respectively. To extend the release time in a controlled manner, KGN is encapsulated in the uniform-sized starch microspheres and DS is loaded into the halloysite nanotubes. Both drug carriers are doped into the maleimide-modified chitosan hydrogel to produce a shear modulus of 167 ± 5 kPa that is comparable to that of articular cartilage (50–250 kPa). Owing to the hydrogel...
Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease
, Article Biomaterials ; Volume 285 , 2022 ; 01429612 (ISSN) ; Shamloo, A ; Nasiri, R ; de Barros, N. R ; Wang, Z. Z ; Unluturk, B. D ; Libanori, A ; Ievglevskyi, O ; Diltemiz, S. E ; Sances, S ; Balasingham, I ; Seidlits, S. K ; Ashammakhi, N ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to the development of organ-on-a-chip devices that can reproduce key functions of various organs. Such platforms promise to provide novel insights into various physiological events, including mechanisms of disease, and evaluate the effects of external interventions, such as drug administration. The neuroscience field is expected to benefit greatly from these innovative tools. Conventional ex vivo studies of the nervous system have been limited by the inability of cell culture to adequately mimic in vivo physiology. While animal models can be used, their relevance to human physiology is uncertain and...