Sharif Digital Repository

Graphene was first discovered as a sheet structure mechanically exfoliated from a block of graphite, but in recent years researchers have extended their investigations into this two-dimensional carbon nanostructure. Various applications of graphene-based materials have included electronics, photonics, optoelectronics, sensors, and drug / gene delivery systems. These single atom carbon layers have the potential to be formed in different morphologies e. g., quantum dots, nanosheets, and nanoparticles, which can be tailored to achieve new breakthrough innovations. Nowadays, the utilization of graphene-based nanomaterials in medicine is a hot research topic. This review discusses the structure,... 

The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers... 

Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among the different types of self-assembled NPs, liposomes stand out for their non-toxic nature and their possession of dual hydrophilic-hydrophobic domains. The advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. First, ligands for... 

Thermal cracking is the prevalent type of distress experienced by asphalt pavements in cold regions. It is widely assumed that when thermal stresses induced in the pavement exceed the tensile strength of the asphalt surface layer, cracking occurs; however, the role of thermal fatigue should not be ignored. To better describe the low-temperature (LT) performance properties of modified asphalt binders, a new parameter, normalised tensile stress (NTS), was defined in this research. NTS values were compared with bending beam rheometer (BBR), direct tension (DT) and semi-circular bending (SCB) fracture test results. The m-value parameter of the BBR test specifies the type of asphalt binder. This... 

For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble... 

Polyhedral oligomeric silsesquioxanes are 3D nanoscaled materials with large potential in solid phase microextraction (SPME). Here, as a case study, an octaglycidyldimethylsilyl modified polyhedral oligomeric silsesquioxane network is described. It was deposited on a stainless steel wire via a sol–gel method and used as a fiber coating for SPME of aromatic compounds. The uniform pore structure, high surface area, and hydrophobicity of the network make it susceptible toward isolation of non-polar and semi-polar chemical compounds. The performance of the fiber coating was tested with three classes of environmental pollutants, viz. chlorobenzenes (CBs), benzenes (benzene, toluene, ethylbenzene,... 

In this study, nonlinear bending of functionally graded (FG) circular sector plates with simply supported radial edges subjected to transverse mechanical loading has been investigated. Based on the first-order shear deformation plate theory with von Karman strain-displacement relations, the nonlinear equilibrium equations of sector plates are obtained. Introducing a stress function and a potential function, the governing equations which are five non-linear coupled equations with total order of ten are reformulated into three uncoupled ones including one linear edge-zone equation and two nonlinear interior equations with total order of ten. The uncoupling makes it possible to present... 

Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like... 

Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20 nm diameter size range) to undergo a color change from red to blue upon aggregation. AuNP assays can be based on cross-linking, non-cross linking or unmodified charge-based aggregation. Nucleic acid-based probes, monoclonal antibodies, and molecular-affinity agents can be attached by covalent or non-covalent means. Surface plasmon resonance and SERS techniques can be utilized. Silver NPs also have attractive optical properties (higher extinction coefficient). Combinations of AuNPs and AgNPs... 

Asphalt concrete is a heterogeneous and multi-phase material that consists of aggregates, asphalt binder, and pores. These components create a complex microstructure. There is no consensus on how to quantify the microstructure and the required parameters from two-dimensional images. The load transfer can be managed by aggregate-aggregate or aggregate-mastic interactions that depend on the gradation, aggregate internal structure, and asphalt binder viscoelastic properties. The most important internal structure indices affecting the behavior of HMA are aggregate orientation, contact orientation, contact length, and number of contact points. In this paper, the influence of aggregate structure... 

The present research comes up with a novel DNA-loaded poly-L-lysine (PLL)/hyaluronan (HA) nanocarrier (DNA-loaded PLL/HA NCs) for gene delivery applications, as a promising candidate for gene delivery into diverse cells. A straightforward approach was employed to prepare such a nanosystem through masking DNA-loaded PLL molecules by HA. Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), field emission-scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) were used to analyse the interaction of the molecules as well as the physicochemical properties of the NCs. The NCs showed a negative charge of –24 ± 3 mV, with an average size of 138 ±... 

Gene therapy has emerged as a promising tool for treating different intractable diseases, particularly cancer or even viral diseases such as COVID-19 (coronavirus disease 2019). In this context, various non-viral gene carriers are being explored to transfer DNA or RNA sequences into target cells. Here, we review the applications of the naturally occurring amino acid histidine in the delivery of nucleic acids into cells. The biocompatibility of histidine-enhanced gene delivery systems has encouraged their wider use in gene therapy. Histidine-based gene carriers can involve the modification of peptides, dendrimers, lipids or nanocomposites. Several linear polymers, such as polyethylenimine,... 

Two qubit density matrices which are of X-shape, are a natural generalization of Bell Diagonal States (BDSs) recently simulated on the IBM quantum device. We generalize the previous results and propose a quantum circuit for simulation of a general two qubit X-state, implement it on the same quantum device, and study its entanglement for several values of the extended parameter space. We also show that their X-shape is approximately robust against noisy quantum gates. To further physically motivate this study, we invoke the two-spin Heisenberg XYZ system and show that for a wide class of initial states, it leads to dynamical density matrices which are X-states. Due to the symmetries of this... 

The high penetration of residential air conditioners (RACs) poses a growing concern in emerging fault-induceddelayed voltage recovery (FIDVR) in power systems. FIDVR is expected to be a significant threat to the stability and reliability offuture power grids. Hence, the system planners should carry out appropriate simulation studies to mitigate the severeconsequences of FIDVR events. A key question to implement these studies is how to determine the worst condition whichresults in FIDVR. Most of the actual FIDVR events have been experienced in the hot hours of the day and this issue makes onecurious to think about the relationship between the FIDVR events and the ambient temperature. In this... 

Nowadays, the energy storage systems (ESSs) are widely used in different level of power systems for dealing with the challenges caused by the integration of renewable energy sources (RESs). Among the ESSs, batteries are more suitable for being used in microgrids (MGs) at distribution level due to their special features. Therefore, this paper presents a novel approach for planning of distributed battery energy storage systems (BESSs) to enhance MGs operation, economically. The model is formulated as a mixed integer nonlinear programming problem (MINLP) and considers various types of BESSs. In order to verify the effectiveness of the proposed approach, it is applied to the IEEE 33-bus network... 

Solid-State Drives (SSDs) are recently employed in enterprise servers and high-end storage systems in order to enhance performance of storage subsystem. Although employing high speed SSDs in the storage subsystems can significantly improve system performance, it comes with significant reliability threat for write operations upon power failures. In this paper, we present a comprehensive analysis investigating the impact of workload dependent parameters on the reliability of SSDs under power failure for variety of SSDs (from top manufacturers). To this end, we first develop a platform to perform two important features required for study: A) a realistic fault injection into the SSD in the... 

Stalling of residential air conditioners (RACs) following a transient fault can delay the voltage recovery ranging from 3 to 20 seconds. This phenomenon is referred to as fault-induced delayed voltage recovery (FIDVR). Several aggregated RAC models have been presented to replicate the actual FIDVR events. However, they usually have two main drawbacks as: i) considering independent stalling voltage and stalling time for all RACs, ii) resulting in only two ultimate modes; either 100% stalled or 100% normal running. This paper amends the abovementioned shortcomings by proposing a simple and effective performance-based RAC model. The proposed model utilizes a simple explicit relation between the... 

Nowadays, the high penetration of renewable energy resources, with variable and unpredictable nature, poses major challenges to operation and planning studies of power systems. Employing energy storage systems (ESSs) has been introduced as an effective solution to alleviate these challenges. Several studies have been presented in the literature to provide a framework for expansion planning studies of ESSs. However, they usually have two main drawbacks: i) ignoring the positive effect of independent-locally operated ESSs on the bulk power system preferences, ii) inability to model the charge/discharge schedule of independent-locally operated ESSs based on their investors' acceptable risk... 

Grid computing is the on-demand sharing of computing resources with in a tightly-coupled network to solve certain problems. One of the main topics is knowledge discovery and data mining. By using grid computing, we can solve this problem. To achieve these very ambitious goals, we present an architecture for applying Association rule mining algorithms on grid environment. Association rule mining seeks to discover associations among transactions encoded in a database on each machine and then send result to related coordinator. This new architecture is powerful and rapid. We tried to compare our method with a serial processing. Our experimental results show that by using the new architecture on... 

Through the strategic highway research program (SHRP) project, time-temperature superposition (TTS) was used to reduce the loading time of bending beam rheometer (BBR) test. Based on TTS, stiffness of the asphalt binder after a two-hour loading time is similar to that after 60 s at 10 °C above. This study attempted to evaluate the TTS validity using finite element (FE) method by developing master curves in a broad range of low temperatures. The results indicated that TTS was neither valid for modified asphalt binders nor for neat binder. Also, in addition to the loading time dependency of m-value, limiting values of stiffness and m-value find no rheological acceptance. As a remedy, thermally...