Sharif Digital Repository

Microfluidic experiments have found wide applications in medical sciences and engineering, such as cell separation and focusing. In the present study, focusing and separation of particles with different sizes and densities were investigated by designing inertial microfluidic devices. The microfluidic channel is designed by analyzing the induced forces on the particles. In the designing process, the objective was to focus and separate the particles in the shortest length of the channel with the lowest possible cycles and high efficiency. The simulation is then used for analyzing the two proposed geometries to evaluate their particle separation and focusing ability, named convergent and... 

In this study, a detailed numerical analysis of the fluid flow and heat transfer of a three-dimensional microchannel is performed to evaluate the effect of using periodic vertical porous and solid ribs with various geometrical shapes, including rectangular, elliptical, isosceles triangular, backward triangular and forward triangular on the walls of this microchannel. Darcy-Brinkman-Forchheimer equations are used to model transport through the porous medium. The results for microchannels with solid ribs and with porous ribs are compared to each other. It is found that at the lowest studied inlet velocity (uin=0.25m/s), for the rib heights of Hr=0.025mm,0.05mmand0.07mm, the average Nusselt... 

In this study, the heat transfer and fluid flow characteristics of a three-dimensional microchannel that is partially filled with a layer of porous medium at its bottom solid wall is investigated. The microchannel is consisted of a clear fluid flow region, solid walls and a porous layer that is attached to its solid bottom wall. A constant heat flux is applied to the bottom wall of the microchannel. Darcy-Brinkman-Forchheimer model is used to simulate the fluid flow inside the porous medium. The novelty of this work is to investigate thoroughly and precisely the effect of using of porous layer configuration in MCHSs on hydraulic and thermal performances. The effect of porous layer thickness,... 

In this article, the thermal and hydraulic capacity of a rectangular microchannel heat sink with different trapezoidal porous configuration’s inlet heights (Formula presented.) and outlet heights (Formula presented.) are examined. A three-dimensional model is used for microchannels with miscellaneous trapezoidal porous configuration’s inlet and outlet heights, and the laminar fluid flow and conjugate heat transfer equations are numerically solved. Darcy-Brinkmen-Forchheimer equation is utilized for transport through the porous region. For microchannels with miscellaneous porous distribution’s inlet and outlet heights, the Nusselt number, pressure drop and figure of merit (FOM), a criterion... 

The dynamics and heat transfer performance of droplets play an important role in electrowetting systems. Contrary to the growing trend towards non-Newtonian fluids in electrotechnical systems, most researchers have focused on Newtonian fluids. In the current study, the interface is tracked by the phase-field method and afterwards, the numerical model is confirmed by comparing the results obtained from previous experimental and theoretical works. Several parameters such as power-law index and contact angle are analyzed. Furthermore, the dynamics and heat transfer of the droplets on chemically or topographically structured substrates in the presence of electrowetting are examined. It has been... 

Nanofluids are widely used as the continuous phase during droplet formation in microsystems due to their impressive features such as excellent thermal, magnetic, and interfacial properties. Although it is well-known that nanofluids are susceptible to exhibit non-Newtonian behavior even at a low concentration of nanoparticles, effects of non-Newtonian behavior of nanofluids have not been studied on droplet formation thus far. In this study, oil-in-water droplet formation with a relatively high viscosity ratio of the immiscible phases was studied numerically in a T-junction microchannel. To inspect the non-Newtonian effects of aqueous nanofluids on droplet formation, empirical data on the... 

Chemical bioreactions are an important aspect of many recent microfluidic devices, and their applications in biomedical science have been growing worldwide. Droplet-based microreactors are among the attractive types of unit operations, which utilize droplets for enhancement in both mixing and chemical reactions. In the present study, a finite-volume-method (FVM) numerical investigation is conducted based on the volume-of-fluid (VOF) applying for the droplet-based flows. This multiphase computational modeling is used for the study of the chemical reaction and mixing phenomenon inside a serpentine microchannel and explores the effects of the aspect ratio (i.e., AR = height/width) of... 

Catalytic decomposition of the ethyl mercaptan over an H-ZSM-5 zeolite in a newly designed microreactor was undertaken in this study. A numerically developed distributor possessing superior flow distribution was amended to 24 parallel microchannels with 64 mm length, 700 μm width, and 600 μm depth. Ethyl mercaptan complete conversion required 350 °C through the developed microreactor while in a conventional fixed-bed-reactor 400 °C was needed. Higher selectivity towards the main products of this decomposition (hydrogen sulfide and ethylene) were observed in this microreactor in comparison to that of a fixed-bed-reactor. In addition, lower selectivity towards formation of byproducts was... 

Despite all the advancements in tissue engineering, one of the unsolved challenges is the mass transfer limitation. Therefore, the subject of pre-vascularization in the engineered tissues gets more attention to avoid necrotic core formation. In this study, we considered a design for interconnected channels with a muscle tissue-like structure, in silico and in vitro. A sequence of simple steps make it possible for us to use the same material, gelatin, as both a sacrificial material and one of the main components of the scaffold simultaneously. We defined a new approach to quantify the repeatability of a new combination of hydrogels (Partially Oxidized Alginate + Gelatin) for extrusion-based... 

Purpose: This paper aims to study the thermal and thermo-hydraulic performances of ferro-nanofluid flow in a three-dimensional trapezoidal microchannel heat sink (TMCHS) under uniform heat flux and magnetic fields. Design/methodology/approach: To investigate the effect of direction of Lorentz force the magnetic field has been applied: transversely in the x direction (Case I);transversely in the y direction (Case II); and parallel in the z direction (Case III). The three-dimensional governing equations with the associated boundary conditions for ferro-nanofluid flow and heat transfer have been solved by using an element-based finite volume method. The coupled algorithm has been used to solve... 

Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to... 

Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to... 

The effect of the hybrid suspension on the intrinsic characteristics of microencapsulated phase change material (MEPCM) slurry used as a coolant in counterflow microchannel heat exchanger (CFMCHE) with different velocities is investigated numerically. The working fluid used in this paper is a hybrid suspension consisting of nanoparticles and MEPCM particles, in which the particles are suspended in pure water as a base fluid. Two types of hybrid suspension are used (Al2O3 +MEPCM and Cu + MEPCM), and the hydrodynamic and thermal characteristics of these suspensions flowing in a CFMCHE are numerically investigated. The results indicated that using hybrid suspension with high flow velocities... 

A surface to separate oil–water mixtures is a global concern and highly needed particularly in oil industries. The present study was conducted to create a novel superhydrophilic/superoleophobic nanocomposite coating on the stainless-steel mesh for the aim of oil/water separation. Different hydrophilic resins along with PFOA as oleophobic agent with 15 flours in its chemical structure and various oxide nanoparticles containing SiO2 and TiO2 at different concentrations were studied to achieve superhydrophilic/superoleophobic surface. The fabricated nanocomposites were fully characterized via field-emission scanning microscopy (FESEM), atomic force microscopy (AFM) and Fourier-transform... 

A novel method involving focusing of magnetic particles at the inner wall of a curved microchannel and secondary Dean flow-based exchange of their fluid was investigated. Solution exchange occurred in a hybrid microchip at very high throughput and with unprecedented solution exchange and particle isolation efficiencies of 99.2% and 90%, respectively. © 17CBMS-0001  

Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in... 

Due to the importance of hydrogen as an effective antioxidant for its applications in therapy, this research reports the fabrication of a coupled microfluidic microbial electrochemical cell (MXC), including microfluidic microbial fuel cells (MFCs) and a microfluidic microbial electrolysis cell (MEC) series in order to perform it as a self-powered biohydrogen generator. Being able to be a platform of implantable medical devices, utilization a non-phatogenic strain of Escherichia coli as the biocatalyst in order to exploit the embodied energy from human blood and excrement and finally the use of cheap and facile materials (<$2 per device) are the exceptional features of the system. The... 

Background and objective: In this study, the effect of the second excitation frequency mode under different conditions on the fluid streaming and its microparticles displacement is investigated. Methods: For this purpose, some variable parameters such as the particle diameter, microchannel aspect ratio, and applied frequency modes have been selected to study. The resulted acoustic streaming was scrutinized to understand the physics of the problem under different geometrical and input conditions. Finally, the effect of the increasing the microparticle size and aspect ratio of the microchannel, simultaneously, has been evaluated. Results: The results demonstrated that increasing the... 

In this study, the effects of geometry and operating conditions upon the thermal and hydraulic performance of Finned Microchannel Heat Sink (FMCHS) were investigated. Water and aluminum were considered as fluid and solid for the computational domain (30 mm × 0.8 mm × 0.8 mm). The Microchannel (MC) was supposed to have 0.65 mm height with an aspect ratio of 0.5. CFD analysis was applied for the assessments of four-types of micro-fins (i.e., conical, pyramidal, cylindrical and cubical). In order to evaluate the effects of height, diameter, the spacing of fins and Reynolds number on the overall performance of FMCHS, central composite design at five levels was used to generate design points.... 

Heat transfer enhancement with microchannel tools has been increased in recent year. In this study effect of geometric parameters as well as Reynolds number have been studied with experimental design approach. A metamodel was generated in this study for pressure drop and average Nusselt number passed all statistical tests. Order of an individual effect upon a response has been evaluated and interaction effects have been determined. Numerical results indicated that heat transfer increased significantly with inserting pyramidal micro fins. © 2020 Elsevier B.V