Sharif Digital Repository

With the advancement of the industry, microscale devices use due to its unique characteristics. On the other hand, it is essential to find ways to reduce drag inside microchannels because of The importance of energy. One of the methods is to optimize the contact surface using structured geometric surfaces. These hydrophobic surfaces reduce drag by trapping the air in roughness and creating a two-phase flow. The purpose of this project is to reduce the drag within the microchannel using structured geometric surfaces for non-Newtonian and multiphase flows. In most previous studies, with simplification, Newtonian and two-phase flows have been investigated. While most industrial fluids show... 

In this article, the problem of mixed convection in vertical rectangular microchannels for both regular fluids and nanofluids have been solved, using the CFD technique in the entrance regions of momentum and heat transfer taking in account the influences of viscous heating, inertial force and sleep conditions. In case of nanofluid flow, both the Brownian and thermophoresis molecular transfer mechanisms were considered.The predicted results were validated using fully developed distributions of velocity and temperature. Furthermore, the influences of mixed convection parameter (Gr/Re) and Kn number values on distributions of velocity and temperature through the entrance and fully-developed... 

Nowadays, cancer, which has been mentioned as the disease of the century, is the second leading cause of death throughout the world, and its incidence is constantly increasing. Isolation of circulating tumor cells is one of the most critical steps in diagnosing and controlling cancer progression. Due to the rarity of cancer cells compared to other cells in the blood sample, the isolation process requires optimal and high-precision devices. With the advent of inertial microfluidics, the ability to control the particles movement, the processing of blood samples as quickly and accurately as possible, and the viability of cells with a high percentage, introduced microfluidic systems as a... 

This thesis presents the prototype design and fabrication of magnetically actuated miniature pumps which utilize self-sealing capability of ferrofluid-covered permanent magnets in both pumping and valving mechanisms. The contactless external actuation feature of the design enables integration of the pump with other PMMA-based microfluidic systems with low cost and disposability. The body of the 1st fabricated prototype pump consists of three nozzle/diffuser elements and two pumping chambers connected to the ends of a flat-wall pumping cylinder. A cylindrical permanent magnet placed inside the pumping cylinder acts as a piston which reciprocates by using an external magnetic actuator driven... 

In medical science, preparing a high purity sample of certain kinds of cells plays an important role in studying the characteristics and functionality of cells, detecting in vitro harmful pathogens and helping to find ways of preventing and treating diseases that cause cellular disorders in the human body. The goal of this research is to improve the spiral microchannel with stair-like cross section in order to separate white blood cells from whole blood. First, the efficiency of this method was evaluated numerically, using a developed finite element model. Then, the desired microchannel mold was made using the micromiling method, and we fabricated the chip using soft lithography and pasting... 

Microfluidics is a field of science that studies micron-scale characteristics of fluids. In this scale fluids show fascinating behavior far beyond our expectation compared to their large-scale counterparts. One of such peculiar behavior is the mixing of two different liquids flowing inside a microchannel. Due to low Reynolds number, the flow inside such a channel would be dominated by laminar behavior. In this regime mixing of the fluids is only mediated by molecular diffusion which is a rather slow process. In the current thesis, we utilized the rotating ability of optical tweezers to construct an active micromixer for Microfluidics. In order to do this we used birefringent microbeads. The... 

Building complex and functional tissues and organs is very challenging. One of the challenges is building an efficient network of blood vessels that can be used to facilitate the transport of nutrients and oxygen to the host. In addition to using channels for oxygen supply, another solution is to use oxygen-carrying materials. In this study, in addition to designing and simulating scaffolds with multi-scale microchannels, calcium peroxide was used to release oxygen and eliminate hypoxia in the scaffold. Here alginate is used as the main material for scaffolding. In an attempt to build a scaffold using a bio-printer, pluronic acid was also used as a sacrificial material to create canals.... 

The effect of using backpressure of air injection in a microchannel on internal flow pressure drop were investigated in this study. Multiphase flows are commonly encountered in gas and oil industries. Flow fields in production operations are often complex and include multiphase flows of gas and liquid. Previously, because of their complex nature, these flow patterns have been mostly investigated only experimentally and empirical correlations based on the experimental data. From another point of view, it is almost impossible to experimentally realize all the flow conditions for each of the flow patterns. Nowadays computer facilities provide the tool to construct and use large-scale... 

Nowadays cell-based microfluidic devices have many applications. One of the applications is disease diagnosis according to number of cells. Cell counting has different methods, such as optical cell counting, flow cytometry, hemocytometry, coulter counters,and so on. One of the methods of cells counting is based on measurement of changes in impedance or conductivity of surrounding medium because ions are released from surface-immobilized cells inside a micr of luidic channel.The method of cell lysate impedance spectroscopy is sensitive enough and it was offered for detecting and enumerating CD4+ cells in HIV patients. In this study,... 

The microfluidic fuel cell or laminar flow-based fuel cell is a membrane-less fuel cell which typically consists of two electrodes mounted within a T- or Y-shaped microchannel. Aqueous fuel and oxidant are introduced from the two inlets of the channel and flow together side-by-side toward the end of the channel. The Reynolds number in the microchannel is low, and hence viscous forces are dominant over the inertial forces. This causes the anolyte and catholyte form a co-laminar flow inside the microchannel which is required to maintain the separation of the fuel and oxidant and limit the reactions to the appropriate electrodes. In this work, a comprehensive numerical model of the microfluidic... 

EOR (oil enhanced recovery) is very important as oil is a nonrenewable resource. Depending on the characteristics of the rock formation, primary production can result in the recovery of up to 20% of the oil originally in the rock. This means that at least 80% of the oil may remain in the rock unless additional technology is used to increase the recovery. Before finding best way to do for EOR, scientists must study properties of different porous media that oil is trapped between its grains. Most of research and studies investigate networks of porous media but this work focused on oil movement through a pore space in porous media lonely not in network by waterflooding. Studying a pore space is... 

In this study, heat transfer and fluid flow inside a rectangular microchannel with partial porous media is simulated numerically. Darcy-Brinkman-Forchheimer equations are used to model the porous media. The effect of height of porous media, permeability (Darcy number), porosity and inlet velocity (Reynolds number) on Hydrodynamic and heat transfer performance are examined. At different values of height of porous media 0.2, 0.4, 0.6, 0.8, and 1 mm the Nusselt number of microchannel are 1.72, 1.78, 1.86, 1.94, and 2.02 compared to the microchannel without porous media. And the porous drop are 1.09, 1.2, 1.49, 1.76, and 2.15 compared to the microchannel without porous media. And FOM are 1.78,... 

In this study, the simulation of two-dimensional supersonic flows through microchannels in slip flow regime is performed using a lattice Boltzmann model (LBM). Traditional LB models have been used to simulate incompressible fluid flows and there are not suitable for modeling compressible or thermo-fluid flows. Herein, a recently developed LB model, namely, the finite difference lattice Boltzmann method (FDLBM), is employed to simulate compressible flows with embedded shocks. In this model, one can select particle velocities independently from the lattice configuration, and therefore, a correct and numerically stable multispeed thermal model by adopting more isotropic particle velocities can... 

Today, with rapid developments and advances in science and technology, different ways have been studied to reduce energy consumption in various industries. Reducing the drag force and thus reducing the friction force is one of these methods which has many applications (e. g, in submarine construction industries). Creating some microgrooves in the microchannels is one of the most effective methods in order to reduce the friction force in microchannels that has recently been studied. In this method the air is trapped within the microgrooves and when the fluid (e. g, water) enters the channel passes over the trapped air within these microgrooves instead of touching the channel walls (solid... 

With the rapid development of mico-nano propulsion systems in micro-spacecrafts and micro-sattelites, precise investigation of flow field in these devices has become necessary. Micro propulsion systems usually have a thrust in order of mili Newton, and they can be used for maneuvers of spacecrafts with mass of less than 10 kg. Micro propulsion systems are usually classified according to their thrust generation mechanism to different classes like cold gas, and chemical propulsion systems. Cold gas micro propulsion systems obtain their energy from thermodynamic expansion of gas and not by combustion. If the flow fiel dimensionare comparable to mean free path, rarefaction effects are observed... 

The goal of the present study is to simulate the compressible rarefied gas flow by using a high-order finite-difference lattice Boltzmann method. Here, a weighted essentially non-oscillatory lattice Boltzmann method (WENO-LBM) is applied for the solution of the compressible form of the LB equation with the Kataoka-Tsutahara model. The solution procedure is based on the discretization of the convection terms of the LB equation using the fifth-order finite-difference WENO scheme and the temporal term using the third-order explicit total variation diminishing Runge-Kutta scheme for both the continuum and rarefied gas flows. The treatment of implementing the no-slip and slip boundary conditions... 

The effects of gravity and inertia dominate our experiences of the physical world. But as systems are reduced in size, phenomena such as diffusion, surface tension and viscosity become ever more important; at the microscale they can dominate and result in a world that operates very differently from the macroscopic world. Kidney is one of the vital organs in which fluid and mass transfer occur between blood flow in microvessels and urine in microchannels called nephron. The present work is aimed at applying microchannel theory to study renal system. First, a n efficient numerical orthogonal collocation method has been employed to solve the steady-state formulation of electrolyte transport in... 

The purpose of this research is the synthesis of nanoparticles using micro fluid glass.The microfluidic glassy building is studied. Glass microfluidic microchannels making hydrophobic the continuing experiments carried out so that the water droplets in the organic phase and at the end of nanoparticles should be synthesized. Tests hydrophobic microchannels and water droplets in the organic phase was formed. In order to ensure an escape water contact angle and FTIR micro-channel test is taken and to avoid the droplets merged with each of surfactant SDS was used. In the end, DLS and FESEM nanoparticles synthesized using the tests have been evaluated and the concentrations of reactants and flow... 

In this project, two Ferrofluidic micropumps that do not need any mechanical moving parts are presented. These micropumps are including simple microchannels containing magnetic fluid plugs that are used as flow actuator and the on/off valve. Using external magnetic field actuation in this type of micropumps, the magnetic fluid would have continuous motion in a channel with micrometer dimensions that would provide the main fluid to be pumped. Although the plug of magnetic fluid has surface contact with operative fluid, but considering its specific features, it would not compine with the pumping fluid. These micropumps may be used to pump the fluids or gases. The outcomes of the investigation... 

Cardiovascular disease (CVD) currently remains a considerable challenge for clinical treatments. CVDs account for N17.5 million deaths per year and will predictably increase to 23.6 million by 2030. The main purpose is to create human model systems to study the effect of disease mutations or drug treatment on the heart. In addition, engineered cardiac tissues are considered promising candidates to be transplanted to improve the function of diseased hearts. For engineered active tissues/organs, 3D bioprinting can fabricate complex tissue architecture with a spatiotemporal distribution of bioactive substances (cells, growth factors, and others) to better guide tissue regeneration. However,...