Sharif Digital Repository

Today, current methods are used for treatment of cancers. Patient experiences a period of hard treatment during destruction of both healthy and diseased cells. Researchers are following stimulus- response drug delivery systems that they control time and position of drug release. Meanwhile, micellar nanoparticles are important, because it can transport the hydrophobic anticancer drugs from body's physiological barriers. On the other hand, tumour tissue has low pH and high temperature as compared to health tissue. Therefore, using pH and thermosensitive polymer coating could be effective in triggered drug release. In the first study, micellar systems were synthesized which were responsive to... 

Recent drug delivery strategies have attempted to maximize the concentration of chemotherapeutic molecules into the tumors, while minimizing their systemic distribution. Doxorubicin has been widely used for a variety of cancers, successfully producing regression in acute leukaemia, lymphomas, soft-tissue and osteogenic sarcomas, paediatric malignancies and adult solid tumours, in particular breast and lung carcinomas. Common adverse effects of doxorubicin include hair loss, myelosuppression, nausea and vomiting, oral mucositis, oesophagitis, diarrhoea, skin reactions and serious reactions include hypersensitivity reactions, radiation recall, heart damage and liver dysfunction. Chitosan has... 

Most available methods which are well able to improve or dewater coarse soils have little success dealing with fine soils and clays and using these methods to dewater clays needs great amount of time and money. Electrokinetic Geosynthetic is one of new methods that have had a promising future. Regarding the importance and tremendous usage of dewatering in fine soils, the efficiency of electrokinetic geosynthetic method in dewatering fine soils has been taken under the consideration in this research. Following laboratory experimentation, numerical modeling of this process has been done. In this research some laboratory test has been done on kaolinite clay and the effects of pH of specimen,... 

One of the major problems in cancer treatment is the side effects of the drugs. Nowadays, scientists are developing smart nanocarriers which used for diagnosis and delivering drugs in order to circulate through blood vessels, pass the immune system, attach to cancer cells and kill them without any side effects. In the first research of this thesis, magnetic nanoparticles were coated by modified alginate and used as smart nanocarriers. Magnetic nanocarrier were sysnthesized based on hydrophobic coating of oleic acid and hydrazine oleate-modified alginate shell. The resulting carrier is pH-sensitive and the alginate shell removes in the low pH medium. DOX was placed between hydrophobic chains.... 

The aim of this work was to synthesize hollow polyaniline nanostructures to be used as pH responsive nanoreservoirs for corrosion inhibitors in self-healing cotings. First, homogeneous and fairly monosized microspherers of polyaniline with nanosized shell was synthesized using a simple soft template method with β-naphthalene sulfonic acid (β-NSA) as both the surfactant and dopant, and ammonium persulfate (APS) as the oxidant at 2-5◦C. The morphology of PANI-NSA was successfully controlled from nanotubes to microsphere, by changing the synthesis conditions (i.e. pH, the concentration of surfactant and monomer, temperature, etc). Then, the nanostructured hollow PANI microspheres were applied... 

The increase in CO2 concentration and its effect on ecosystem and global warming make carbon sequestration inevitable for now and future. Ex-situ carbonation of mineral ores is one of the studied sequestration methods. This method is permanent and safe in comparison with others. This process is carried out in four steps and two phases in this dissertation. At the first stage magnesium was extracted from its mineral silicate ore (Mixture of serpentine and olivine) by hydrochloric acid (HCl) and was dissolved in liquid phase as ion. After that the resultant leachate of extraction step was purified from unwanted ions extracted from minerals in two steps by precipitation formed by increasing pH.... 

Man’s struggle for optimization in different areas has been an endless one. Optimizing methods of cancer treatment is not an exception. Because of numerous side effects of anti-cancer drugs, drug delivery systems (DDS) have been recently given much interest. Considering some aspects, DDS are helpful in reducing harmful effects of anti-cancer drugs and more efficient healing by these drugs: first by reducing the dosage of drug by controllable and sustainable release of drug in a kinetic (diffusion) pattern; second by smart release of drug in target tissue which in turn protects sound tissues not to be in contact with drug.In this study, three kinds of nanoparticles have been used for DDS... 

Microbial electrolysis cell is a novel technology for hydrogen production. The biggest challenges for this new technology are low rate of hydrogen production and high investment cost.
In this research, catholite condition was investigated for increasing the rate of hydrogen production. Low price stainless steel was used as cathode electrod. The microbial electrolysis cell operated applying 1.3 v external voltage. Basic pH was found to be the best condition for maximum rate of hydrogen production, where the average rate of hydrogen production was 100.006 1.866 L/m3.d. However, the hydrogen production rate for the acidic and neutral cathodic condition, were 92.89 1.13 and 91.845 1.485... 

One of the major problems in cancer treatment is side effects of treatments. Today, scientists have developed smart nanocarrier for diagnosis and drug delivery that can circulate in the bloodstream, pass the body's immune system to kill cancer cells and attach to the cancer cells to deliver drugs, without the side effects that are in other treatments, such as chemotherapy. magnetic nanoparticles coated by biodegradable polymers are one of the smart polymers. In this study, iron oxide nanoparticles with amine group on their surface are coated by starch modified by methyl acrylate then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the... 

Proteins are of fundamental importance for life on Earth and participate in virtually every process within cells. The function of a protein depends on its three dimensional structure. If this is disrupted, the protein loses its biological activity. In addition to temperature, pressure and ionic strength, pH is also an important factor that affects the configuration of proteins. Proteins contain acidic and basic residues. Variations in pH lead to changes in distribution of atomic charge, which in turn affect the stability and function of proteins. Protein folding occurs in a specific pH range, a deviation from which may facilitate misfolding or Amyloid aggregation. It is therefore necessary... 

Combustion synthesis is the best and most effective method for producing ceramic nano-composites which is also a simple and economic way of producing very fine powders with high purity. In this method, a series of combustion reactions named aqueous combustion analysis are used for producing single-phase and nano-composite products ,in which the heat produced in reactions are used for completing the phase . several chemical substances such as glycine ,urea ,ammonium acetate and others are used as combustion agents. In order to obtain optimized nano fuel, we produced alumina powder with multiple combustion percentages and composition of 25%moli ammonium acetate (AA) with 75%moli urea was... 

Particle reinforced aluminum matrix composites have considerable attraction in automotive and aerospace industries due to their special properties as light weight, high ratio of strength/density, improved elastic modulus, low coefficient of thermal expansion and high wear and corrosion resistance. Among the production processes of metal matrix composites, accumulative roll bonding process has particular importance due to producing ultrafine grained composite sheets. However, uncontrolled and undesired agglomeration of particles is the main problem in producing these composites. In this research, the Al2O3 and SiC nanoparticles were electrostatically stabilized against agglomeration by... 

In this work, a novel type electrode based on RuO2 nanoparticles-modified vertically aligned carbon nanotubes (RuO2/MWCNTs) was investigated. ThisRuO2/MWCNTs electrode not only shows a high capacity nature,but also possesses a good response to the pH value. In order to develope this sensor, aligned carbon nanotubes were synthesized by the chemical vapor deposition at first and then modified with RuO2 nanopartcles by sol-gel method. Various parameters affecting the growth of nanotubes, such as substrate type, surface finishing, surface roughness, the growth temperature and carbon feed rate was studiedand and optimal conditions for growth were obtained. At last, aligned nanotubes with a... 

TiO2 is one of the most frequently used photocatalyst materials. Porous TiO2 nanostructure has drawn much attention recently due to high decomposition rate of organic pollutants. In this thesis, TiO2 nanoparticles were synthesized via sol-gel method and were coated on cotton and jute fiber separately; besides, the impregnated fibers were heat treated to eliminate cellulose. Titanium tetraisopropoxide (TTIP) was used as a precursor and two solutions, acidic and alcoholic, were used as the primary solutions for synthesis. In acidic solution, the crystalline phase and size distribution of TiO2 nanoparticles were evaluated with changing pH.Then, the appropriate pH was chosen for coating. In... 

In this project, function of anaerobic digestion of organic waste in liquid phase and treating the following sewage in biologic tower(trickling filter) has been investigated in an experimental process. Solid waste were supplied from sharif university restaurant and after weighting and classification is added to tanks which filled by 40% sludge and 60% water. For controlling the function of biologic tower, a control reactor were used. Retention time for digestion of solid waste is 40 day. First solid loading was 500g and 75g organic waste in main & control reactor equal to 5(kg solid waste)/( m^3.reactor.day) 1.3(kg TS)/( m^3.reactor.day) and were doubled in second loading. It seems that... 

Yttrium Aluminum Garnet powders possessing controlled size distribution has found applications in production of transparent ceramics, phosphors, laser host materials and composites. Sol-Gel Combustion process is one of the versatile methods to produce nanometeric garnet powders. This procedure is based on combustion of a concentrated gel of metal salts and fuel in an exothermic reaction which leads to nanoparticles formation. pH value of solution and employed fuel system strongly affect production quality and single phase nanopowder can be synthesized by well monitoring these parameters. In this study nanocrystalline Yttrium Aluminum Garnet powders was Synthesized via sol-gel combustion... 

Drug targeting to specific organs and tissues has become one of the critical endeavors of the new century. Magnetic nanoparticles have gained a lot of attention in biomedical and industrial application. Doxorubicin is an effective anti-cancer drug in the treatment of many types of cancers. The aim of this study is to load doxorubicin on stimuli-responsive nanocarriers. These nanocarriers are prepared from magnetic nanoparticles. Then these magnetic nanparticles are coated by copolymer of poly(glycidyl methacrylate) then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This... 

In this research, we have studied optimization of culture medium and process factors for high alkaline protease production from Bacillus subtilis ATCC 6633 for detergent usage. Five parameter soy bean meal, initial pH, agitation rate, MgSO4, CaCl2 were selected for more studies. At first, one-factor-at-a-time method was applied to investigate effect of each factor separately. Then, optimum condition for maximum protease production was achieved using Minitab software Box-benhnken procedure. According to results, high protease production was seen in soy bean meal, 35 (g/L); MgSO4, 1 (g/L); CaCl2 , 1.5 (g/L); initial pH, 7; agitation rate, 150; inoculum ratio, 12% (v/v). The activity of the... 

In recent years, advances have been made in the field of miniaturization of the devices (in order to increase their efficiency, lessen the materials needed for the constructions and experiments, reduce costs and energy usage) resulting in the dramatic increase of surface to volume ratio in these devices. This progress has led to the dominance of surface forces which can be used to control very important interface phenomena having a special application such as electrokinetic. Using today’s manufacturing technology; it is possible to construct micro-nanochannels made from different materials such as silicon, glass, quartz, polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA) whose... 

To protect mild steel against corrosion, an intelligent self-healing epoxy (EP) coating including carbon nanofiber (CNF) modified with polydopamine (PDA)-La (III) complex was successfully fabricated. The high aspect ratio and unique thermal and electrical characteristics of CNF made it an ideal physical barrier against the penetration of corrosive ions. Due to the poor dispersion of CNF, its surface was modified using PDA. PDA, which contains functional groups such as catechol, amine, and imine, can mitigate corrosion reaction by generating the Fe-Catechol complex and also boost the coating's adherence to the metal surface, in addition to anchoring La3+ inorganic corrosion inhibitor....