Search for: physiological-models
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    Modeling the Relationship between Central Aortic Pressure and Radial Photoplethysmogram in Flow-mediated Dilation Test

    , Ph.D. Dissertation Sharif University of Technology Parsafar, Mohammad Habib (Author) ; Vosughi Vahdat, Bijan (Supervisor) ; Zahedi, Edmond (Supervisor)
    According to the World Health Organization, about 35% of deaths worldwide are due to cardiovascular diseases, therefore the evaluation of vascular endothelial function has great prognostic and diagnostic value for cardiovascular diseases. The conventional noninvasive method for endothelial function evaluation is the measurement of flow-mediated dilation in brachial artery using ultrasound imaging (FMD-US). As the accuracy of FMD-US depends on the operator's skill and the resolution of the ultrasound images, this method has not been adopted. In this work, we propose to use a low cost, easily-accessible surrogate signal, the photoplethysmogram (PPG) to implement the FMD test. Whereas previous... 

    Modeling of Human Decision Making in Problem Solving Based on Physiological Models of Neuron

    , M.Sc. Thesis Sharif University of Technology Shirzadeh, Hossein (Author) ; Vosughi Vahdat, Bijan (Supervisor)
    How the human nervous system works is one of the most important topics in science and in this topic providing a model of it is scientists' main concern. The human brain that has been formed from a large number of nerve cells lets it do complex computations. The structure of cognition, memorizing and processing which are some of human features are being studied in many fields of science named "brain and cognitive science".
    In this study, we will point to modeling of one of the human cognitive phenomena (decision making in problem solving). In this modeling, we aim to connect the microscopic and macroscopic levels of the nervous system to each other.
    First, we will give an introduction... 

    A new mathematical approach for detection of active area in human brain fMRI using nonlinear model

    , Article Biomedical Engineering - Applications, Basis and Communications ; Volume 22, Issue 5 , 2010 , Pages 409-418 ; 10162372 (ISSN) Taalimi, A ; Fatemizadeh, E ; Sharif University of Technology
    Functional magnetic resonance imaging (fMRI) is widely-used for detection of the brain's neural activity. The signals and images acquired through this imaging technique demonstrate the human brain's response to pre-scheduled tasks. Several studies on blood oxygenation level-dependent (BOLD) signal responses demonstrate nonlinear behavior in response to a stimulus. In this paper we propose a new mathematical approach for modeling BOLD signal activity, which is able to model nonlinear and time variant behaviors of this physiological system. We employ the Nonlinear Auto Regressive Moving Average (NARMA) model to describe the mathematical relationship between output signals and predesigned... 

    A robotic model of transfemoral amputee locomotion for design optimization of knee controllers

    , Article International Journal of Advanced Robotic Systems ; Volume 10 , 2013 ; 17298806 (ISSN) Shandiz, M. A ; Farahmand, F ; Osman, N. A. A ; Zohoor, H ; Sharif University of Technology
    A two-dimensional, seven link, nine degrees of freedom biped model was developed to investigate the dynamic characteristics of normal and transfemoral amputee locomotion during the entire gait cycle. The equations of motion were derived using the Lagrange method and the stance foot-ground contact was simulated using a five-point penetration model. The joint driving torques were obtained using forward dynamic optimization of the normal human gait and applied to the intact joints of the amputee. Three types of motion controllers; frictional, elastic and hydraulic were considered for the prosthetic joints of the amputee and their design parameters were optimized to achieve the closest... 

    Dynamic simulation of the biped normal and amputee human gait

    , Article Mobile Robotics: Solutions and Challenges - Proceedings of the 12th International Conference on Climbing and Walking Robots and the Support Technologies for Mobile Machines, CLAWAR 2009, 9 September 2009 through 11 September 2009, Istanbul ; 2010 , Pages 1113-1120 ; 9814291269 (ISBN) ; 9789814291262 (ISBN) Shandiz, M. A ; Farahmand, F ; Zohour, H ; Sharif University of Technology
    A two-dimensional seven link biped dynamic model was developed to investigate the mechanical characteristics of the normal and amputee locomotion during the complete gait cycle. The foot-ground contact was simulated using a five-point penetration contact model. The equations of motion were derived using Lagrange method. Optimization of the normal human walking model provided constant coefficients for the driving torque equations that could reasonably reproduce the normal kinematical pattern. The resulting torques were then applied to the intact joints of the amputee model with a prosthetic leg equipped with a kinematical driver controller for the ankle and either a hydraulic, elastic or... 

    Uncontrolled manifold analysis of gait kinematic synergy during normal and narrow path walking in individuals with knee osteoarthritis compared to asymptomatic individuals

    , Article Journal of Biomechanics ; Volume 141 , 2022 ; 00219290 (ISSN) Shafizadegan, Z ; Sarrafzadeh, J ; Farahmand, F ; Salehi, R ; Rasouli, O ; Sharif University of Technology
    Elsevier Ltd  2022
    Knee osteoarthritis (KOA) is a common musculoskeletal disorder resulting in altered gait patterns. Uncontrolled manifold (UCM) analysis has been demonstrated as a useful approach for quantitative analysis of motor variability and synergies. The present study aimed to investigate the changes in the kinematic synergy, controlling the center of mass (COM) position while walking on normal and narrow paths in people with KOA compared to asymptomatic participants. In this cross-sectional study, twenty people with mild to moderate KOA and twenty asymptomatic individuals walked at their comfortable preferred speed across normal and narrow paths on a treadmill. The UCM analysis was performed... 

    Prosthetic knee using of hybrid concept of magnetorheological brake with a T-shaped drum

    , Article 2015 IEEE International Conference on Mechatronics and Automation, ICMA 2015, 2 August 2015 through 5 August 2015 ; Aug , 2015 , Pages 721-726 ; 9781479970964 (ISBN) Sayyaadi, H ; Zareh, S. H ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    This paper focuses on developing a new configuration on magnetorheological (MR) brake damper as prosthetic knee. Knee uses magnetic fields to vary the viscosity of the MR fluid, and thereby its flexion resistance. Exerted transmissibility torque of the knee greatly depends on the magnetic field intensity in the MR fluid. In this study a rotary damper using MR fluid is addressed in which a single rotary disc will act as a brake while MR fluid is activated by magnetic field in different walking gait. The main objective of this study is to investigate a prosthetic knee with one activating rotary disc to accomplish necessary braking torque in walking gait via implementing of Newton's equation of... 

    Model-based fiducial points extraction for baseline wandered electrocardiograms

    , Article IEEE Transactions on Biomedical Engineering ; Volume 55, Issue 1 , 2008 , Pages 347-351 ; 00189294 (ISSN) Sayadi, O ; Shamsollahi, M. B ; Sharif University of Technology
    A fast algorithm based on the nonlinear dynamical model for the electrocardiogram (ECG) is presented for the precise extraction of the characteristic points of these signals with baseline drift. Using the adaptive bionic wavelet transform, the baseline wander is removed efficiently. In fact by the means of the bionic wavelet transform, the resolution in the time-frequency domain can be adaptively adjusted not only by the signal frequency but also by the signal instantaneous amplitude and its first-order differential, which results in a better baseline wander cancellation. At the next step the parameters of the model are chosen to have the least square error with the original ECG. Determining... 

    Investigation of the different parameters contributing to bubble sticking inside physiological bifurcations

    , Article Medical and Biological Engineering and Computing ; Volume 60, Issue 2 , 2022 , Pages 599-618 ; 01400118 (ISSN) Salajeghe, R ; Saidi, M. S ; Sharif University of Technology
    Springer Science and Business Media Deutschland GmbH  2022
    Gas embolotherapy (GE) is a developing medical method which can be utilized either as an autonomous therapeutic method to treat vascularized solid tumors, or it can be combined with other medical procedures—such as high-intensity focused ultrasound—to improve their efficiency. This paper is dedicated to investigating the different parameters which influence bubble lodging inside human vasculature via 2D-modeling of bubble dynamics in arteries’ and arterioles’ bifurcations which are potential sticking positions. Values used in the simulations are in accordance with the non-dimensional physiological numbers. It is found out that inlet pressure plays a decisive role in bubble lodging; the lower... 

    A novel distributed model of the heart under normal and congestive heart failure conditions

    , Article Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine ; Volume 227, Issue 4 , 2013 , Pages 362-372 ; 09544119 (ISSN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    Conventional models of cardiovascular system frequently lack required detail and focus primarily on the overall relationship between pressure, flow and volume. This study proposes a localized and regional model of the cardiovascular system. It utilizes noninvasive blood flow and pressure seed data and temporal cardiac muscle regional activity to predict the operation of the heart under normal and congestive heart failure conditions. The analysis considers specific regions of the heart, namely, base, mid and apex of left ventricle. The proposed method of parameter estimation for hydraulic electric analogy model is recursive least squares algorithm. Based on simulation results and comparison... 

    Introducing a distributed model of the heart

    , Article Proceedings of the IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, 24 June 2012 through 27 June 2012 ; June , 2012 , Pages 419-424 ; 21551774 (ISSN) ; 9781457711992 (ISBN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    Conventional models of cardiovascular system (CV) frequently lack required detail. Once utilized to study the heart function, these models focus primarily on the overall relationship between pressure, flow and volume. This study proposes a localized and regional model of the CV system. It utilizes non-invasive blood flow and pressure seed data and temporal cardiac muscle regional activation to predict the operation of the heart. Proposed localized analysis considers specific regions of the heart, namely base, mid and apex sections of the left ventricle. This modular system is based on a hydraulic electric analogy model, estimating desired parameters, namely resistance (R), compliance (C),... 

    Robust control of LVAD based on the sub-regional modeling of the heart

    , Article Scientia Iranica ; Volume 23, Issue 6 , 2016 , Pages 2934-2943 ; 10263098 (ISSN) Ravanshadi, S ; Jahed, M ; Sharif University of Technology
    Sharif University of Technology  2016
    Left Ventricular Assist Devices (LVAD) have received renewed interest as a bridge-to-transplantation as well as a bridge-to-recovery device. Ironically, reports of malfunction and complications have hindered the growth of this device. In particular, the main concern is LVAD's susceptibility to excessive backlash and suction as a result of ows that are either too low or high, respectively. This study utilizes a well-established physiological model of the cardiovascular system as a reliable platform to study a proposed adaptive robust controller for a rotary motor based LVAD which overcomes such shortcomings. Proposed controller performance is evaluated by comparing simulated natural heart... 

    Evaluation of endothelial response to reactive hyperaemia in peripheral arteries using a physiological model

    , Article International Journal of Biomedical Engineering and Technology ; Volume 33, Issue 4 , 2020 , Pages 305-324 Parsafar, M. H ; Zahedi, E ; Vahdat, B. V ; Sharif University of Technology
    Inderscience Publishers  2020
    Non-invasive measurement of flow-mediated dilation (FMD) in the brachial artery for assessing endothelial function is costly and operator-dependent, limiting its application to research cases. In this paper, an approach based on a physiological model between normalized central blood pressure and finger photoplethysmogram is presented. Baseline model parameters are estimated using a genetic algorithm in 30 subjects consisting of ten normal blood pressure (BP), ten high-BP and ten elderly volunteers. Beat-to-beat fitness values after reactive hyperaemia are calculated using baseline (before cuff occlusion) data. Results show that stimulus-induced changes are fairly described with a first order... 

    Development a planar neuro-musculoskeletal arm model in post-stroke patients

    , Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 236-241 ; 9781728156637 (ISBN) Nikzad Goltapeh, A ; Asghari, M ; Behzadipour, S ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Computational models of the central nervous system after a stroke helps to reveal the physiological mechanisms that may have strong impacts on the neuro-motor rehabilitation approaches. This paper studies the stroke subject's motor control mechanism in reaching movements by extending the previous study by incorporating the kinematics of motion as well as neural disconnection between the muscles and the CNS to further develop a planar patient specific neuro-musculoskeletal model of arm. The developed model was calibrated to eight post-stroke individuals by altering the Muscle Significance Factors (MFS) using numerical optimization to match the simulated motions with those measured... 

    Tracking the 3D configuration of human joint using an MR image registration technique

    , Article ASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition, BIOMED 2010, 20 September 2010 through 21 September 2010 ; 2010 , Pages 93-94 ; 9780791849453 (ISBN) Mostafavi Yazdi, S. K ; Farahmand, F ; Jafari, A ; Sharif University of Technology
    Surface registration is a necessary step and widely used in medical image-aided surgery. It's relevance to medical imaging is that there is much useful anatomical information in the form of collected surface points which originate from complimentary modalities. In this study, the kinematic relations between two point clouds with different coordinate definitions have been generated. Using Influence Method of surface modeling for extracting point clouds functions, the transformation matrix would be resulted. The proposed method was applied for an experimental femur data points(651 points) using the MRI images. These data points were transformed in a 30 degrees flexion of knee. This... 

    Improved artificial neural networks for 3D body posture and lumbosacral moment predictions during manual material handling activities

    , Article Journal of Biomechanics ; Volume 131 , 2022 ; 00219290 (ISSN) Mohseni, M ; Aghazadeh, F ; Arjmand, N ; Sharif University of Technology
    Elsevier Ltd  2022
    Body posture measurement approaches, required in biomechanical models to assess risk of musculoskeletal injuries, are usually costly and/or impractical for use in real workplaces. Therefore, we recently developed three artificial neural networks (ANNs), based on measured posture data on several individuals, to predict whole body 3D posture (coordinates of 15 markers located on body's main joints), segmental orientations (Euler angles of 14 body segments), and lumbosacral (L5-S1) moments during static manual material handling (MMH) activities (ANNPosture, ANNAngle, and ANNMoment, respectively). These ANNs require worker's body height, body weight (only for ANNMoment), hand-load 3D position,... 

    An integrated human stress detection sensor using supervised algorithms

    , Article IEEE Sensors Journal ; Volume 22, Issue 8 , 2022 , Pages 8216-8223 ; 1530437X (ISSN) Mohammadi, A ; Fakharzadeh, M ; Baraeinejad, B ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2022
    This paper adopts a holistic approach to stress detection issues in software and hardware phases and aims to develop and evaluate a specific low-power and low-cost sensor using physiological signals. First, a stress detection model is presented using a public data set, where four types of signals, temperature, respiration, electrocardiogram (ECG), and electrodermal activity (EDA), are processed to extract 65 features. Using Kruskal-Wallis analysis, it is shown that 43 out of 65 features demonstrate a significant difference between stress and relaxed states. K nearest neighbor (KNN) algorithm is implemented to distinguish these states, which yields a classification accuracy of 96.0 ± 2.4%. It... 

    Physiological and psychological neural system modeling for a key-pressing test

    , Article Proceedings of the IASTED International Conference on Biomedical Engineering, Salzburg, 25 June 2003 through 27 June 2003 ; 2003 , Pages 66-70 ; 0889863539 (ISBN) Mahmudi, H ; Shahdi, S. A ; Vahdat, B. V ; IASTED ; Sharif University of Technology
    The model introduced in this article for neural system describes both physiological and psychological concepts of neural system and is based on the models of individual elements of the system. This model includes psychological characteristics such as; perception, prediction, learning and response planning, and physiological features such as; sensory analysis, memory and motor execution. The model is designed in such a way that it describes the performance of the neural system for a key-pressing test. The key-pressing experiment consists of a screen with numbers from 1 to 9, which is shown to the operator where one of the numbers is specified by a special color and the operator is to push the... 

    A unimodal person authentication system based on signing sound

    , Article Proceedings - IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics, BHI 2012 ; 2012 , Pages 152-154 ; 9781457721779 (ISBN) Khazaei, D ; Maghooli, K ; Afdideh, F ; Azimi, H ; Sharif University of Technology
    IEEE  2012
    Person authentication based on only the name, password or person identification number is not secured enough. In recent years researchers have focused on human physiological and behavioral parameters, because these parameters are more unique and human-specific than traditional ones. This approach of person authentication is usually called biometric authentication. Signature is the most commonly used behavioral biometric which is investigated in two ways of online and offline by researchers. In online procedure, the temporal indices of signature such as signing velocity, and acceleration are involved to increase the accuracy relative to offline methods and to recognize counterfeit signatures.... 

    Effects of different corneal ring segments with identical total arc length on keratoconic eyes: a finite element study

    , Article 26th National and 4th International Iranian Conference on Biomedical Engineering, ICBME 2019, 27 November 2019 through 28 November 2019 ; 2019 , Pages 1-3 ; 9781728156637 (ISBN) Katoozian, H. R ; Sajadi, S. B ; Khanlari, M ; Gholami, M ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Keratoconus (KC) is a progressive corneal disease. It is mostly characterized by corneal thinning and irregular steepening as well as formation of cone-shaped regions on the cornea. Amongst treatment modalities, implantation of Intrastromal Corneal Ring Segments (ICRSs) could decrease corneal surface irregularities. However, controversy exists over the selection of proper ICRSs. Here, the aim was to compare the effects of two sets of ICRSs. The ICRSs were identical both in cross-section and total arc length. The results showed that under normal physiological range of intraocular pressures (IOPs), the two selected ICRSs caused slightly different deformations in the same in-silico keratoconic...