Sharif Digital Repository

Drug targeting to specific organs and tissues has become one of the critical endeavors of the new century. Magnetic nanoparticles have gained a lot of attention in biomedical and industrial application. Doxorubicin is an effective anti-cancer drug in the treatment of many types of cancers. The aim of this study is to load doxorubicin on stimuli-responsive nanocarriers. These nanocarriers are prepared from magnetic nanoparticles. Then these magnetic nanparticles are coated by copolymer of poly(glycidyl methacrylate) then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This... 

Today, with improvements in industries such as the sensitive equipment’ industries and the optics industries which need great precision for their optimum performance, the need for a vibration-free environment is felt more than ever. The main objective in this thesis is the effective reduction of the effects of ambient vibrations on points on an optical concrete table using active control. In this research, other than separating the table with the passive method, the reduction of vibrations with active control and the LQR algorithm is investigated. In order to study the dynamic characteristics of the table and to observe the active control process better and more carefully, finite element... 

Joint price and service capacity decisions and integrated pricing and queuing problems with finite or infinite buffers are two remarkable issues of pricing research. In this thesis we consider a joint price and service capacity determination problem in a single server, finite buffer queuing system. Customers arrival and serving occur as Poisson processes. Because of finite buffer capacity, customers finding the system full upon their arrival would be rejected. Customers differ with respect to their reservation prices and time sensitivities. This study focuses on investigating the effect of finite buffer capacity and customers reservation prices and time sensitivities on optimal policy and... 

In this work, a model was presented for an MCFC fuel cell with internal reforming and combustion chamber. The model consists of mass and heat transfer equations beside the chemical and electrochemical reaction rate equations. Velocity distribution due to reactions and temperature distribution along the cell is considered. The model has been simulated in steady state form using finite difference method in MATLAB package environment accompanied by the analysis of the dynamic behavior of cell using method of lines in Simulink environment. Simulation results have been validated with experimental data extracted from literature. The last part of the work concerns with sensitivity analysis of some... 

Atomic force microscope (AFM) has a significant capability of imaging surface topography on an atomic scale. It is also widely used for Nanolithography in MEMS/NEMS (micro/nanoelectromechanical systems). Conventional AFMs consist of a cantilever with a sharp conical or pyramidal tip located at the free end of the cantilever that plays an important role in AFM measurements. Scanning across a surface, AFM interacts with the sample surface through its tip. Although the dynamic behavior of the AFM cantilever is complicated, the researchers have been interested in studying AFM dynamic behavior because it has a great influence on the surface imaging process. The imaging rate and contrast of... 

Nowadays, the world is full of multi criteria decision problems and all the people should make decisions in different situations. Sometimes, the result of a decision problem is so important as a wrong decision may result in a loss that cannot be compensated. Therefore a decision making tool seems as a must. On the other hand, in this era of rapid social and technological change leading to increasing life complexity, sensitivity analysis is an important issue in all decision making processes. Analytic Hierarchy Process and Analytic Network Process, as two common tools for multi criteria decision making, are widely used throughout the past decade in different fields. Designing the model and... 

Risk is an uncertain event or condition that, if it occurs, has a positive or negative effect on a project’s objectives. Identification and assessment of risk in a measurable way are so important for project managers to decide better. This thesis studies how to identify and assess the project’s risks in Fishery industry based on the Project management body of knowledge (PMBOK 2008) as a global standard. Constructing an aquaculture site in Abadan city has some risks which are identified in the first steps of the study and in the following steps these risks will be prioritized by the use of qualitative analysis and figured out which risks have major effects on projects objectives. In last step... 

A two-dimensional, two-phase, nonisothermal model was developed in this work to investigate the water transport characteristic and water distribution in a direct methanol fuel cell (DMFC). Emphasis is placed on exploring the water distribution in different layers of DMF. The water and methanol crossover through the membrane were considered with the effect of diffusion, electro-osmotic drag, and convection. Governing equations including the prton and electron transport, continuity, momentum, species transport for methanol, water, and gases species, and the auxiliary equations are coupled to determine the output parameters. These parameters are the concentration distribution of the species,... 

Quantitative estimation of baseflow is necessary for hydrological modeling of a watershed, ground-surface water interaction, water supply reliability, and vulnerability, especially during a dry period, and answering questions pertaining to the responses of human-based activities on natural ecosystems. Extensive research effort spanning more than 50 years provided collections of field, manual, and computer-based methods for baseflow separation study. In this study, a comprehensive review is carried out on the nine digital filters, six graphical methods, four tracer-mass-balance methods, fourteen recession analysis methods, and two frequency analysis methods. Sensitivity analyses of baseflow... 

Smart heat-sensitive polymers play a unique role in drug delivery systems due to reversible behavior in response to environmental changes, especially temperature changes. Among the heat-sensitive polymers, UCST polymers due to their specific behavior and very little-known polymers with this feature are the subject of many new researches. In the present study, New designed temperature-sensitive polymers with UCST capability based on acrylamide and vinyl acetate were synthesized. These copolymers were synthesized in different percentages of acrylamide by free radical polymerization in solution conditions. All polymers compounds were characterized by H-NMR, FT-IR, DSC and GPC measurements. The... 

Proton precession magnetometers are one of the most sensitive scalar magnetic sensors. Their function is based on Zeeman effect and also nuclear magnetic resonance phenomena. In this project we have designed and implemented needed coils, swithching and signal detection circuits. Because of extremely high sensitivity of this sensor to induced noises and also gradient of earth’s magnetic fileld, detection of precession signal needs design of low noise electronic circuits with special EMC considerations. The implemented system in this project contains different blocks, such as switching circuit and its related control unit, amplifier, filter and frequency meter. Using this system, the obtained... 

Stress Absorbing Membrane Interlayer (SAMI) is a slightly thin layer made of bitumen and aggregate placed between a pavement with limited cracking and overlay in order to avoid reflective cracking in overlay. SAMI’s performance depends on many factors such as pavement layer’s materials and thickness and existing pavement’s condition. Numerical simulations are powerful tools to evaluate SAMI’s performance. Previous studies showed that construction of SAMI does not necessarily reduce reflective cracking. This research investigated the effect of different parameters on SAMI’s performance using numerical simulations. The focus of this study was on the performance of SAMIs used between asphalt... 

Climate change has overshadowed various aspects of human life due to rising greenhouse gases such as carbon dioxide. The importance of this issue prompted humans to take steps to reduce carbon dioxide emissions from human activities. Turning to geothermal energy instead of using fossil fuels was one of the strategies chosen for this purpose. Geothermal reservoirs are used to exploit this energy. In geothermal reservoirs, cold water is injected through a fracture network and receives heat from the hot rocks; then, the hot water is pumped out. Due to their high transmissivity compared to the surrounding rock matrix, Fractures are the primary conductors in geothermal reservoirs. Flow-through... 

In this research we focus on study and fabrication of one dimentianal TiO2 nanostructures and nanoheterostructures on TiO2 nanofibers in order to use them in Dye Sensitized Solar Cells (DSC). Nanofibers of titanium oxide have been fabricated using hydrothermal method. Then, hierarchical TiO2 nanostructures were grown on the nanofibers via another hydrothermal step. Increasing the effective surface of nanofibers, we achieved two secondary architectures from fibers:1-Nanoparticular fibers (TiO2 nanoparticles grown on nanofibers).2-Nanostars.After fabrication, the SEM and XRD characterizations were provided. Furthermore, the suitable pastes of these nanostructures were prepared for application... 

One of the major issues raised in the numerical models is the effects of various input parameters on the model output. Identifying the most important parameters in the output is very important in petroleum engineering, especially in tuning equation of states and history matching. Screening the most important parameters from unimportant parameters is assessable by sensitivity analysis.In this study local and global sensitivity analysis methods are used to identify the most important parameters in tuning EOS for seven different fluid samples. Global sensitivity analysis methods are more successful in correct ranking of tuning parameters. Morris method as a global method can screen the... 

Dye-sensitized solar cells (DSSCs) are emerging as low-cost alternatives to conventional, solid-state, silicon solar cells. A porous network of a nanosize semiconductor material with a wide band-gaps usually TiO2, serves as charge transport medium. A monolayer of dye is chemically adsorbed on this material. Photoexcitation of dye causes injection of electrons into the conduction band of TiO2 from where they diffuse towards a transparent conducting oxide (TCO) substrate. The dye is regenerated through receiving electrons from a redox couple dissolved in the electrolyte. After passing through a desired load, the electrons enter the cell through a counter electrode to reduce the redox ions and... 

Tire is one component of the suspension system and has beneficial effects on reducing vibrations caused to the vehicle. This study aims to determine the factors affecting the damping and stiffness of the tire is carried out. The modeling of factors were identified. For testing the modeling effort is to be made to the instruments used to measure the damping and stiffness of the tires. To make the structural static analysis, dynamic and modal was to have sufficient structural strength and the displacements and stresses are sensibly placed. Factors that have influence on the hardness of the ring diameter, the outer diameter of the tire, tire pressure, tire tread depth, tire wall thickness,... 

By the use of flexible substrates like metal foils and meshes and plastic ones, fabrication of flexible dye sensitized solar cells are possible. Flexible dye sensitized solar cell, not only is utilized in portable, light electronic devices, but is also conductive to industrial roll to roll fabrication which enables the implementation of high throughput production lines and its associated potential reduction in manufacturing costs. This thesis has concentrated on fabrication of flexible dye sensitized solar cells by use of stainless steel mesh as substrate of photo-anode, because of its satisfying stability in electrolyte, flexibility, transparency and low cost. In this research, an efficient... 

Any factor that causes an additional pressure drop to the reservoir is called damage. Damages due to drilling, well completion and production can cause additional pressure drop to formation. In this study, damage caused by mechanical damage, well deviation from vertical (angled well), partially completed well and horizontal well and formation damage behavior during the occurrence of water and gas coning phenomenon have been investigated by simulation and the results have been verified with the analytical models available for calculating the formation skin factor. Also, by studying and examining the data and the results obtained from the simulation of the horizontal well skin factor in a data... 

During an earthquake, if the seat width provided at the joint is less than the relative joint opening, the bridge’s superstructure becomes unseat which leads to potential collapse due to the lack of support. Because of the catastrophic consequences of loss of support and the perception that the damage could easily be prevented at relatively low cost, some retrofitting programs focus on preventing such failures involved the addition of longitudinal restrainer cables and bars to limit the relative movements at expansion joints. Noticing the weaknesses of usual restrainers including the transmission of excessive forces to substructures, weak capability of energy dissipation during severe...