Sharif Digital Repository

Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e. passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications... 

Targeted drug delivery systems using nanocarriers offer a versatile platform for breast cancer treatment; however, a robust, CD44-targeted niosomal formulation has not been developed and deeply studied (both in vitro and in vivo) yet. Here, an optimized system of epirubicin (Epi)-loaded niosomal nanoparticles (Nio) coated with hyaluronic acid (HA) has been engineered for targeting breast cancer cells. The nanoformulation was first optimized (based on size, polydispersity index, and entrapment efficiency); then, we characterized the morphology, stability, and release behavior of the nanoparticles. Epirubicin release from the HA-coated system (Epi-Nio-HA) showed a 21% (acidic buffer) and 20%... 

Herein, a facile and versatile method for the synthesis of a novel magnetic nanocarrier via surface- initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is introduced. At first, RAFT agent was successfully attached to the surface of Fe 3 O 4 nanoparticles and, then, poly (glycidyl methacrylate) (PGMA) chains were grown and anchored onto the surface of Fe 3 O 4 nanoparticles. At the end, hydrazine (Hy) groups were introduced to the PGMA chains via reaction between epoxy rings and hydrazine molecules. Doxorubicin (DOX) was covalently conjugated to the prepared nanocarrier (Fe 3 O 4 @PGMA@Hy) through a hydrazone linkage. The in vitro drug release of Fe 3 O 4... 

Surface-modified magnetite (Fe3O4) nanoparticles with an average size of 22 nm were prepared. The nanoparticles had a saturation magnetization of 50.7 emu g-1. Then magnetite and drug-loaded microspheres of poly (lactic acid)/poly (ethylene glycol) were prepared at various compositions. The microspheres were spherical in shape and had smooth surface. The diameter size of the microspheres ranged between about 0.2 and 4 μm. Doxorubicin hydrochloride for cancer treatment was the drug that loaded into the microspheres. The prepared microspheres were characterized by FTIR, XRD, VSM, SEM and drug-release measurements. It was found that the drug cumulative release percentage was proportional to... 

Iron oxide nanoparticles, γ-Fe2O3NP, were deposited onto the surface of multi-walled carbon nanotubes and CNT/γ-Fe2O3NP hybrid nanomaterials were obtained. Then linear-dendritic ABA type block copolymers consisting of polyethylene glycol as B block and poly(citric acid) as A block, PCA-PEG-PCA, were synthesized and cisplatin (cis-diamminedichloroplatinum (CDDP) - a platinum-based chemotherapy drug) was conjugated with their carboxyl functional groups and CDDP/PCA-PEG-PCA anticancer prodrugs were prepared. Noncovalent interactions between CDDP/PCA-PEG-PCA anticancer prodrugs and CNT/γ-Fe2O3NP hybrid nanomaterials led to CDDP/PCA-PEG-PCA/CNT/γ-Fe2O3NP drug delivery systems. There are several... 

Background and Objective: The present article has simulated to investigate the efficient hemodynamic parameters, the drug persistence, and drug distribution on an abdominal aortic aneurysm. Methods: Blood as a non-Newtonian fluid enters the artery acting as a real pulse waveform; its behavior is dependent on hematocrit and strain rate. In this simulation of computational fluid dynamic, magnetic nanoparticles of iron oxide which were in advance coated with the drug, are injected into the artery during a cardiac cycle. A two-phase model was applied to investigate the distribution of these carriers. Results: The results are presented for different hematocrits and the nanoparticle diameter. It...