Sharif Digital Repository

Photodynamic therapy that has developed over last century, now has become more widely used medical tool for the treatment of various diseases such as cancer. This technique involves delivery of photosensitizing drugs, irradiation of light and motivation of drugs. The limitation of light penetration in body tissue, may resolve by application of upconversion nanoparticles. Upconverting nanoparticles could help treatment of cancer tumors in deep or critical points of body by converting high penetrating Near-Infrared emissions to higher energy visible emissions.In this research Er3+-Yb3+ Co-doped titanium dioxide upconversion nanoparticles prepared by Sol-gel method. The phase structure and... 

The nanoparticles have been widely used in the field of physics, chemistry, electronics and mechanics because of their high surface area. One of their most important applications is in drug delivery systems as smart drug nanocarrier. Magnetic nanoparticles (including Fe2O3, Fe3O4) are the good candidates for this purpose. It is clear that, upon to entrance of nanoparticle into biological media (such as plasma), the surface of nanoparticles were covered by protein layers (protein corona). This layer is very stable and created new surface on the nanoparticles. The protein corona layer intracts with cellular receptors and determines the fate of nanoparticles. Protein corona covers the targeting... 

Particle retention and clearance is a major concern in the treatment of pulmonary diseases. Inhaled materials into the nasal and lung airways include gases/vapors, liquid droplets and soluble/insoluble particulate matter which can be toxic or therapeutic (or both). For example, nanoparticles (NPs), as part of nanomedicine, are now being used as drug carriers for passive and active targeting of solid tumors and inflamed tissue. However, natural and especially manmade NPs can also be harmful, such as carbon nanotubes (CNTs), asbestos fibers and ambient toxic pollutants, based on epidemiological and pathological studies of occupational and environmental exposures. In fact, ultrafine particles... 

Many of industrial processes include suspension in their middle section of production, final product or residue. Majority of these two-phase mixtures are unstable due to their large particle size (larger than one micrometer). Therefore, Study of particle distribution in suspensions for generation of stabilized suspension becomes significant. In this study a new mechanism in stabilization of microparticle suspension known as nanoparticle halo mechanism has been assessed. Experiments have been conducted in dilute suspension and two-way coupling range. The effect of the presence of silica nanoparticle on zirconia microparticle suspension has been investigated. The effect of zeta potential of... 

In this study the effect of nanoparticles on the mass transfer of dispersed phase in the liquid-liquid extraction systems, containing toluene with acetic acid as dispersed phase and saturated water of toluene as continues phase was investigated. For the ease of dispersion of nanoparticles in nonpolar organic dispersed phase, with the use of a novel method, hydrophobic tiania nanoparticles were synthesized and during producing with the sole-gel method were modified by adding Tetraethyl Ortho titanate as modifying agent, also the smallest hydrophobic nanoparticles of magnetite were synthesized by co-precipitating method and then, under optimum thermal condition were coated by adding Oleic... 

In this research, the effect of feed flow concentration on the separation of gas mixture of carbon dioxide and oxygen was investigated by using supported liquid membrane in the presence of nano particles. In order to achieve this purpose, supported liquid membranes were prepared by impregnating a porous hydrophilic PVDF support with TEG, cyclohexanol, TEG/Fe3O4 nano particles and cyclohexanol/ Fe3O4 nano particles. Permeability and selectivity of mixed gases CO2 and O2 were examined at five different CO2 concentrations in feed flow, constant feed flow rate and constant total pressure difference.
In all tests, the permeance of carbon dioxide through cyclohexanol and TEG membranes was... 

This thesis is divided into two parts: In part I, which is theoretical part, we were looking for a computational method which is extensively comparable with experimental results to determine pKa of wide variety of organic compounds. The pKa is an important property in many sciences such as chemistry, biology, and material science, since inclination of a compound to donate or accept a proton is fundamental to understanding many chemical and biochemical processes. Experimentally determined pKa values are not always available from literature sources and often estimated values are employed in their place. It is useful, therefore, to have reliable and accurate means of calculating relative and/or... 

In this work the effect of recycling process and nanometric CaCO3 on the rheological and heat-sealing properties of co-polymer Polypropylene (R40) was studied. Nanocomposites with recycled and neat matrix were prepared with twin extruder. Complex viscosity, dynamic modulus, flexural and tensile properties, impact strength and sealing ability of nanocomposites of neat Co-PP (R40) and Recycled Co-PP (RPP) determined according to the relevant standard specifications.Rheological analysis revealed that incorporation of nanofiller enhances values of Complex viscosity and dynamic modulus, broadening molecular weight distribution (MWD) and decrease cross over point (ωc, GC) for RPP. In this study,... 

The theory of mass transfer accompanied by chemical reaction for gas-liquid systems was used to measure the specific interfacial area and mass transfer coefficient in a two impinging jets reactor (TIJR) in the presence of γ-Al_2 O_3 nanoparticles.The absorption of oxygen in sulfite solutions used for the determination of mass transfer characteristics. First 3 liters of nanofluids were prepared at concentration of 1 w% then diluted To produce 10 Liters of nanofluids containing 0.3 w%. The stability of this nanofluid was determined using uv-vis to be less more than 95% in the first 3 hours. The influence of weight percent of nanoparticles (0, 0.05, 0.1, 0.15, 0.2, 0.3) on the specific... 

Age-related macular degeneration (AMD) is the most common cause of vision loss in those aged over 50. There are two main types of AMD, Wet and Dry form. Wet AMD is more severe though more treatable. There are three conventional treatments for AMD including laser therapy, surgery and intravitreal injection of anti-VEGF into the eye. Delivery of drugs to the posterior segment of the eye is still challenging and several implants and devices are currently under investigation for their ability to stimulate the retina, producing visual percepts. The application of intravitreal bevacizumab (Avastin) has expanded tremendously from the time of its introduction into ophthalmic care since 3 years ago.... 

In the present study, synthesis, preparation, and application of bimetallic iron/nickel nano-particles were experimentally investigated with the aim of groundwater remediation. Firstly, iron/nickel nano-particles were synthesized according to chemical reduction and stabilization with starch biopolymer, and then characterized. Results confirmed the formation of bimetallic iron/nickel nano-particles with mean size of 75 nm that starch placed around of them. The more stability characteristic and also enough mobility ensure their diffusion through porous media. Secondly, reactivity of synthesized nano-particles for removal of various contaminants including nitrate, chromium, and lead were... 

The growing use of nanomaterials leads to causing harm to the aquatic environment resulting in a demand for effective methods to remove these nanomaterials from aquatic environment. On the other hand, the high cost of raw materials used for the production of noble metal nanomaterial limits their use or requires the development of recycling and recovery methods. In this study, we found that citrate capped gold nanoparticles (cit-AuNPs) could be removed effectively from waste water using aluminum chloride (AlCl3) coagulant. The effect of pH, of coagulant concentration, and alkalinity on the performance of this coagulant was investigated. It has... 

In the first part, a novel electrochemical sensor based on nanocellulose-carbon nanoparticles (NC–CNPs) nanocomposite film modified glassy carbon electrode (GCE) is developed for the analysis of metoclopramide (MCP). The electrochemical behavior of MCP was investigated on the surface of the modified electrode using cyclic voltammetry (CV). Characterization of the surface morphology and properties of NC/CNPs was carried out by scanning electron microscopy (SEM), atomic force microscopy (AFM) and electrochemical impedance spectroscopy (EIS). Effective experimental variables, such as scan rate, pH of the supporting electrolyte, drop size of the casted modifier suspension and accumulation... 

In the recent years, sensors and biosensors attracts much attentions as a suitable devices in analytical chemistry. In this meantime carbon nanostructures and metal nanoparticles act as a good choice owing to their unique properties such as high electrical conductivity andmechanical and chemical stability in modification of the surface of sensors and biosensors. Because of importance of analysis the trace amounts of pharmaceutical and biological compounds, in this studies the surface of glassy carbon electrode was modified with some carbon nanostructures and metal nanoparticles for electrochemical investigation and determination of pharmaceutical and clinical compounds.In the first work, a... 

In this study Ni-P-Al2O3-SiO2 nano composite coating developed on aluminium alloy 6061 using electroless method. Due to oxidation of aluminium, a double zincate pretreatment performed to obtain proper adhesion of coating on substrate. Effect of solution temperature and heat treatment on thickness and property of nano composite coating was studied. Furthermore, effect of concentration of nano particles in electroless solution on thickness, morphology, micro hardness, wear behavior, corrosion resistance and particle content in coating were investigated. Field emission scanning electron microscopy (FESEM, Hitachi S-4160) with energy dispersive spectroscopy (EDS) was used to evaluate morphology... 

Age-related macular degeneration (AMD) is the most common cause of vision loss in those aged over 50. There are two main types of AMD, Wet and Dry form. Wet AMD is more severe though more treatable. There are three conventional treatments for AMD including laser therapy, surgery and intravitreal injection of anti-VEGF into the eye. Delivery of drugs to the posterior segment of the eye is still challenging and several implants and devices are currently under investigation for their ability to stimulate the retina, producing visual percepts. The application of intravitreal bevacizumab (Avastin) has expanded tremendously from the time of its introduction into ophthalmic care since 3 years ago.... 

In This project high purity Zinc (Zn) Nanoparticles were synthesized using Electromagnetic Levitation Melting Gas Condensation method. In this method the designed coil plays an important role on melting and suspension of the material and our design was costumed specifically for zinc nanoparticles. For each batch of synthesized Zn nanoparticles, 1.5 gr zinc platelet was levitated in the costumed coil and the effect of different parameters on the size and distribution of nanoparticles, was investigated including in- different cooling gas (He, N2 and Argon), gas flow rate, and the pressure inside the chamber. Inert gas was used to cool supersaturated vapor above the molten droplet and eliminate... 

Nanotechnology as an interdisciplinary science is used in many fields. The use of nanomaterial, make new opportunities in the industry. However, safety issues and environmental risks of the consequences of their use in various applications are the matters of concern. Because of the new emergence of this technology, it is essential that all aspects including possible harmful effects on the environment will also be considered. One way to remove the nanoparticles, is electrocoagulation method, assemble nanoparticles into larger particles with an electric current. In this study, the removal of titanium dioxide nanoparticles, due to its high use in the industry, with electrocoagulation method and... 

The aim of this project is the surface modification of super para magnetic iron oxide (SPIONs), leading to oriented covalent bonding of antibody(AB) to these nanoparticles (NPs) and improve the efficiency of cell separation at MACS columns. For this purpose, SPIONs synthesized by co-precipitation method, and the stability of colloidal NPs then was provided by coating with Dextran . We used TGA to measure weight percentage of dextran. Some properties like particle size, hydrodynamic diameter, presence of coating and superparamagnetic properties were characterized by XRD (16 nm), FTIR, DLS (73 nm), TEM (20nm) and VSM (≈76/78 emu/g) method, respectively. Then we tried to immobilize AB on NPs... 

The electrochemical oxidation behavior of the anti-inflammatory drug piroxicam was investigated. A carbon nanoparticle (CNP)-chitosan (CS) film-coated graphite electrode (PGE) was fabricated and the electrochemical behaviors of piroxicam on its surface was investigated by the means of cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS). In comparison to the bare PGE, at the surface of the CNP-CS film modified electrode, the oxidation peak current of piroxicam increased significantly and the peak potential shifted negatively. Consequently, a simple and sensitive electroanalytical method was developed for the determination of piroxicam. The...