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Development of HAp/GO/Ag coating on 316 LVM implant for medical applications
, Article Journal of the Mechanical Behavior of Biomedical Materials ; Volume 126 , 2022 ; 17516161 (ISSN) ; Izanloo, S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
In this study, antibacterial activity, biocompatibility, and corrosion resistance of 316 LVM implants were improved using the development of HAp/GO/Ag nanocomposite coatings by the dip-coating method. The XRD and FTIR results confirmed the synthesis of HAp/GO/Ag nanocomposites. HAp/Ag nanoparticles (68 nm) bound to epoxy, hydroxyl, and carboxyl functional groups on GO sheets (size of GO sheets varies from 255 to 1480 nm) by electrostatic interaction. FESEM images showed that HAp/GO/Ag coatings had higher density and fewer micro-cracks than pure HAp coatings. In addition, HAp/GO/Ag coatings showed optimized nano-hardness (4.5 GPa) and elasticity modulus (123 GPa). The results of...
Efficient one-pot four-component synthesis and X-ray crystallographic structure of 2-pyridone derivatives
, Article Journal of Heterocyclic Chemistry ; Volume 50, Issue 6 , 2013 , Pages 1272-1280 ; 0022152X (ISSN) ; Hashemi, M. M ; Khezri, S. H ; Rominger, F ; Ghabraie, E ; Oeser, T ; Sharif University of Technology
2013
Abstract
A series of 3-cyano-2-pyridone derivatives were synthesized by one-pot four-component condensation reaction involving a benzaldehyde derivative, alkyl cyanoacetate, acyclic or cyclic ketones, and ammonium acetate in reflux condition. The X-ray structure of the products 5a and 5d confirm symmetric dimers via hydrogen bonding interactions between individual pyridine molecules showing, in addition, also π-π stacking interactions
Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systems
, Article Colloids and Surfaces B: Biointerfaces ; Volume 182 , 2019 ; 09277765 (ISSN) ; Taebnia, N ; Yaghmaei, S ; Shahbazi, M. A ; Mehrali, M ; Dolatshahi Pirouz, A ; Arpanaei, A ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Great advantages bestowed by mesoporous silica nanoparticles (MSNs) including high surface area, tailorable pore diameter and surface chemistry, and large pore volume render them as efficient tools in biomedical applications. Herein, MSNs with different surface chemistries were synthesized and investigated in terms of biocompatibility and their impact on the morphology of bone marrow-derived mesenchymal stem cells both in 2D and 3D culture systems. Bare MSNs (BMSNs) were synthesized by template removing method using tetraethylorthosilicate (TEOS) as a precursor. The as-prepared BMSNs were then used to prepare amine-functionalized (AMSNs), carboxyl-functionalized (CMSNs) and polymeric...