Sharif Digital Repository

Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals. This study discusses different tissue- and organ-on-chip platforms (i.e., skin, brain, blood–brain barrier, bone marrow, heart,... 

Rings are widely used in mechanical equipment, and their fitness may undergo some damage under severe vibration. In these structures, functionally graded rings can be used to optimize the resistance, energy consumption, and fitness. Due to their complexity, the finite-element analysis may be implemented using special elements. Enhancement of accuracy and minimization of time consumption play an important role in the analysis of these rings. In this study, a new cylindrical superelement for the FGM rings is designed and implemented to facilitate the vibration analysis of the rings. The power-law distribution is used for the modeling of the FGM rings in the thickness direction. Natural... 

As Gregory Bateson, the British social scientists, once said "You can't live without an eraser", the process of learning is not a unidirectional way toward accumulation of knowledge, rather, organizations should critically evaluate the value of their knowledge and if necessary, actively forget no-longer-useful knowledge. A brief review of related literature shows that the concept of knowledge active forgetting (KAF) is a crucial aspect of organizational learning and knowledge management. However, many aspects of this topic deserve more attention by researchers. The main gap in the literature seems to be related to the linkage between peculiar aspects of knowledge (such as stickiness, context... 

In this study, the cost function of the defined system is derived first. Then, we prove this function is convex in the system's base stock level. Finally, based on the convexity of the cost function, the optimal solution for the base stock model is determined. For demonstrating the applicability of the proposed method, we resort to solving an example. © 2009 Asian Network for Scientific Information  

Epoxy resins have been used as structural materials since the late 1940s. Despite their desirable properties such as high strength, excellent creep resistance, and good adhesion, they suffer from low fracture energy. Rubber modification as a major toughening approach to overcome the inherent brittleness of epoxy polymers was introduced during the early 1970s. Since then, a large number of investigations have been conducted to elucidate different aspects of rubber-toughened epoxies. The present work is a critical review of the field focusing on the important parameters affecting rubber-toughening. The studies reviewed are classified in five categories including roles of matrix ductility,... 

In this paper, an exact solution procedure is presented for the Weighted Earliness-Tardiness Project Scheduling Problem (WETPSP) with Generalized Precedence Relations (WETPSP-GPR), taking into account the time value of money (WETPSPDC-GPR) and a fixed deadline for the project. The WETPSP-GPR extends the WETPSP to arbitrary minimal and maximal time-lags between the starting and completion times of activities. We present a new depth-first Branch and Bound (B&B) algorithm for an extended form of the problem, in which the time value of money is taken into account by discounting cash flows, and minimum, as well as maximum, time-lags between different activities may be given. The algorithm is... 

Alzheimer’s disease (AD) is an irreversible neurological disorder that progresses gradually and can cause severe cognitive and behavioral impairments. This disease is currently considered a social and economic incurable issue due to its complicated and multifactorial characteristics. Despite decades of extensive research, we still lack definitive AD diagnostic and effective therapeutic tools. Consequently, one of the most challenging subjects in modern medicine is the need for the development of new strategies for the treatment of AD. A large body of evidence indicates that amyloid-β (Aβ) peptide fibrillation plays a key role in the onset and progression of AD. Recent studies have reported... 

Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.... 

Signal generation techniques for visual detection of analytes have received a great deal of attention in various sensing fields. These approaches are considered to be advantageous when instrumentation cannot be employed, such as for on-site assays, point-of-care tests, and he althcare diagnostics in resource-constrained areas. Amongst various visual detection approaches explored for non-invasive quantitative measurements, ratiometric fluorescence sensing has received particular attention as a potential method to overcome the limitations of intensity-based probes. This technique relies on changes in the intensity of two or more emission bands (induced by an analyte), resulting in an effective... 

Despite tremendous efforts toward vaccination, influenza remains an ongoing global threat. The induction of strain-specific neutralizing antibody responses is a common phenomenon during vaccination with the current inactivated influenza vaccines, so the protective effect of these vaccines is mostly strain-specific. There is an essential need for the development of next-generation vaccines, with a broad range of immunogenicity against antigenically drifted or shifted influenza viruses. Here, we evaluate the potential of whole inactivated vaccines, based on chemical and physical methods, as well as new approaches to generate cross-protective immune responses. We also consider the mechanisms by... 

As one of the most important additive manufacturing (AM) techniques, laser metal deposition (LMD) has been extensively studied specially during the last few years. Similar to other AM techniques, the quality of LMD parts is highly dependent on the processing parameters that need to be optimized so as to obtain geometrically accurate parts as well as favorable microstructures and, thus, mechanical properties. The present review paper therefore aims to present a critical analysis and overview of the relationship between processing parameters, microstructure, and mechanical properties of LMD components made from the Ti–6Al–4V alloy. Moreover, we discuss the applications of LMD parts in the... 

Today's world energy-related challenges, ranging from anthropogenic climate change to continuous growth of demand for different energy forms, have enforced planners of energy systems (ESs) to concentrate on more optimal and eco-friendly operation and/or expansion planning methodologies. In this context, increased interdependencies of gas, heat and electricity ESs have recently encouraged the planners to design operation and/or expiation strategies in an integrated manner in favor of a new concept, the so-called “Energy Hub” (EH). Although this concept has been employed so far in a multitude of studies, but its real nature, advantages, difficulties, importance or inevitability aspect, and... 

Diabetes affects a large population of the world. Lifestyle, obesity, dietary habits, and genetic factors contribute to this metabolic disease. A target pathway to control diabetes is the 5′-adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. AMPK is a heterotrimeric protein with α, β, and γ subunits. In several studies, AMPK activation enhanced glucose uptake into cells and inhibited intracellular glucose production. Impairment of AMPK activity is present in diabetes, according to some studies. Drugs used in the treatment of diabetes, such as metformin, are also known to act through regulation of AMPK. Thus, drugs that activate and regulate AMPK are potential... 

Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and low... 

Considering the wide spread locations of wind farms in Iran, it is important to develop a suitable decision support system (DSS) to fulfill proper management of wind farms. Extensive literature survey indicates that there are no integrated forms of DSS to manage a set of wind farms. The existing wind farms are performing independently, and there is no practical method for exchanging the online data. DSS can contribute to optimal operation of wind farms, operation and maintenance scheduling, pricing policy, etc. In this study, a geographic information system and RETSCREEN software were linked to the designed DSS to achieve a more suitable result. Also, a huge number of data are constantly... 

Nanotechnology is gaining more attention in biotechnological applications as a research area with a huge potential. Nanoparticles (NPs)can influence the rate of anaerobic digestion (AD)as the nano-sized structures, with specific physicochemical properties, interact with substrate and microorganisms. The present work has classified the various types of additives used to improve the AD processes. Nanomaterials as new additives in AD process are classified into four categories: Zero-valent metallic NPs, Metal oxide NPs, Carbon based nanomaterials, and Multi-compound NPs. In the following, application of nanomaterials in AD process is reviewed and negative and positive effects of these materials... 

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in... 

Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via... 

During the last few decades, nanotechnology has established many essential applications in the biomedical field and in particular for cancer therapy. Not only can nanodelivery systems address the shortcomings of conventional chemotherapy such as limited stability, non-specific biodistribution and targeting, poor water solubility, low therapeutic indices, and severe toxic side effects, but some of them can also provide simultaneous combination of therapies and diagnostics. Among the various therapies, the combination of chemo- and photothermal therapy (CT-PTT) has demonstrated synergistic therapeutic efficacies with minimal side effects in several preclinical studies. In this regard,... 

Using network analysis, we investigate if an industry's complex and integrated knowledge base leads to a higher spatial concentration (or dispersal)of innovative activities. This is important because the extant literature provides competing claims about how knowledge base complexity impacts on the spatial distribution of industrial innovation. To help empirically resolve this issue, we draw on longitudinal data (1970–2010)on the upstream petroleum industry and build indexes of entropy and complexity to render knowledge base dynamics, assess the spatial concentration of innovation, and study industry structural transformations. We first find a correlation – once a crucial distinction between...