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Inorganic nanomaterials for chemo/photothermal therapy: a promising horizon on effective cancer treatment

Khafaji, M ; Sharif University of Technology | 2019

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  1. Type of Document: Article
  2. DOI: 10.1007/s12551-019-00532-3
  3. Publisher: Springer Verlag , 2019
  4. Abstract:
  5. During the last few decades, nanotechnology has established many essential applications in the biomedical field and in particular for cancer therapy. Not only can nanodelivery systems address the shortcomings of conventional chemotherapy such as limited stability, non-specific biodistribution and targeting, poor water solubility, low therapeutic indices, and severe toxic side effects, but some of them can also provide simultaneous combination of therapies and diagnostics. Among the various therapies, the combination of chemo- and photothermal therapy (CT-PTT) has demonstrated synergistic therapeutic efficacies with minimal side effects in several preclinical studies. In this regard, inorganic nanostructures have been of special interest for CT-PTT, owing to their high thermal conversion efficiency, application in bio-imaging, versatility, and ease of synthesis and surface modification. In addition to being used as the first type of CT-PTT agents, they also include the most novel CT-PTT systems as the potentials of new inorganic nanomaterials are being more and more discovered. Considering the variety of inorganic nanostructures introduced for CT-PTT applications, enormous effort is needed to perform translational research on the most promising nanomaterials and to comprehensively evaluate the potentials of newly introduced ones in preclinical studies. This review provides an overview of most novel strategies used to employ inorganic nanostructures for cancer CT-PTT as well as cancer imaging and discusses current challenges and future perspectives in this area
  6. Keywords:
  7. Chemo/Photothermal therapy ; Gold-based nanomaterials ; Iron- based nanomaterials ; Metal Sulfiedbased nanomaterials ; Albumin ; Alpha beta poly (n 2 hydroxyethyl) dl aspartamide ; Biopolymer ; Bismuth sulfide nanoparticle ; Chitosan ; Copper sulfide nanoparticle ; Doxorubicin ; Glutathione ; Gold nanoparticle ; Gold nanorod ; Gold nanoshell ; Hermes antigen ; Inulin ; Macrogol ; Mesoporous carbon nanosphere ; Metal organic framework ; Nanocarrier ; Nanocomposite ; Nanomaterial ; Nanosphere ; Polyglactin ; Quantum dot ; Reactive oxygen metabolite ; Silk fibroin ; Trastuzumab ; Ultrasmall superparamagnetic iron oxide ; Unclassified drug ; Bioaccumulation ; Biocompatibility ; Biodegradation ; Cancer chemotherapy ; Cancer diagnosis ; Chemical modification ; Drug cytotoxicity ; Drug delivery system ; Drug distribution ; Drug release ; Human ; Immune response ; Membrane permeability ; Molecular stability ; Morphology ; Nanoencapsulation ; Nanofabrication ; Near infrared spectroscopy ; Nonhuman ; Phagocytosis ; Photodegradation ; Photothermal therapy ; Priority journal ; Review ; Static electricity ; Surface plasmon resonance ; Thermostability
  8. Source: Biophysical Reviews ; Volume 11, Issue 3 , 2019 , Pages 335-352 ; 18672450 (ISSN)
  9. URL: https://link.springer.com/article/10.1007/s12551-019-00532-3