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Green synthesis of PEG-coated MIL-100(Fe) for controlled release of dacarbazine and its anticancer potential against human melanoma cells
, Article International Journal of Pharmaceutics ; Volume 618 , 2022 ; 03785173 (ISSN) ; Vossoughi, M ; Bagherzadeh, M ; Pooshang Bagheri, K ; Sharif University of Technology
Elsevier B.V
2022
Abstract
In this study, the potential of using MIL-100(Fe) metal–organic framework (MOF) for loading and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of melanoma. The drug loading was performed during the green synthesis of MIL-100(Fe) in an aqueous media without using any harmful solvents, to obtain MIL-DTIC. The surface of this structure was then coated with polyethylene glycol (PEG) in the same aqueous solution to synthesize MIL-DTIC-PEG. The synthesized samples were characterized using various methods. Their release profile was studied in phosphate-buffered saline (PBS) and simulated cutaneous medium (SCM). The cytotoxicity of DTIC and its nano-MOF...
Synergistic Wound Healing by Novel Ag@ZIF-8 Nanostructures
, Article International Journal of Pharmaceutics ; Volume 629 , 2022 ; 03785173 (ISSN) ; Mohsen Dehnavi, S ; Ahmadi Seyedkhani, S ; Yahya Rahnamaee, S ; Golizadeh, M ; Sharif University of Technology
Elsevier B.V
2022
Abstract
In this paper, novel zeolitic imidazolate framework-8 (ZIF-8) functionalized with Ag (Ag@ZIF-8) nanoparticles were synthesized through a green, facile and environmental-friendly process for wound dressing applications. X-ray diffraction revealed that the ZIF-8 and Ag@ZIF-8 were successfully synthesized by green solvents at ambient temperature. Field-emission scanning electron microscopy indicated a homogeneous porous blend of ∼30 nm chitosan/bacterial cellulose (CS/BC) nanofibers embedded with ∼80–110 nm nanoparticles of the ZIF-8 and Ag@ZIF-8. Transmission electron microscopy revealed the Ag@ZIF-8 nanostructures consist of ZIF-8 cores that are covered by 5–20 nm Ag nanoparticles. MTT assay...
Experimental Study of Partitioning of Lysozyme Enzyme in Aqueous Two-Phase Systems based on Surfactants
, M.Sc. Thesis Sharif University of Technology ; Bastani, Dariush (Supervisor) ; Vosoughi, Manochehr (Supervisor)
Abstract
In this study, aqueous two-phase systems (ATPS) containing Tween 20 as a biocompatible nonionic surfactant and three different salts (NH4HPO4, NH4CH3COO and Mg(CH3COO)2 ) were prepared and their extractive potential for Lysozyme enzyme was evaluated. These systems have surfactant-rich top phase and salt-rich bottom phase. Phase equilibrium diagrams at 23 ° C were obtained by using the cloud point method and the results were successfully fitted to the Merchuk correlation and their trends were correlated with the effective excluded volume (EEV) parameter. Afterward, the partitioning behavior of the lysozyme and its extraction efficiency in the systems of Tween 20/diammonium hydrogen phosphate,...
Probability of missed detection as a criterion for receiver placement in MIMO PCL
, Article IEEE National Radar Conference - Proceedings, 7 May 2012 through 11 May 2012, Atlanta, GA ; 2012 , Pages 0924-0927 ; 10975659 (ISSN) ; 9781467306584 (ISBN) ; Chitgarha, M. M ; Radmard, M ; Nayebi, M. M ; Sharif University of Technology
IEEE
2012
Abstract
Using multiple antennas at the transmit and receive sides of a passive radar brings both the benefits of MIMO radar and passive radar. However one of the obstacles arisen in such configuration is the receive antennas placement in proper positions so that the radar performance is improved. Here we just consider the case of positioning one receiver among multiple illuminators of opportunity. Indeed it is a start for the solution of optimizing the geometry of the multiple receivers in a passive radar
An efficient method for the ring opening of epoxides with aromatic amines by Sb(III) chloride under microwave irradiation
, Article Journal of Chemical Research ; Issue 4 , 2008 , Pages 220-221 ; 03082342 (ISSN) ; Hashemi, M. M ; Mottaghi, M. M ; Foroughi, M. M ; Sharif University of Technology
2008
Abstract
SbCl3 supported on montmorillonite K-10 is an efficient catalyst for the ring opening of epoxides with aromatic amines under solvent-free conditions and microwave irradiation to give the corresponding b-amino alcohols in high yields with high regioselectivity
MIMO radar signal design to improve the MIMO ambiguity function via maximizing its peak
, Article Signal Processing ; Volume 118 , 2016 , Pages 139-152 ; 01651684 (ISSN) ; Radmard, M ; Nazari Majd, M ; Karbasi, S. M ; Nayebi, M. M ; Sharif University of Technology
Elsevier
2016
Abstract
One of the important obstacles in MIMO (Multiple Input Multiple Output) radars is the issue of designing proper transmit signals. Indeed, the capability of signal design is a significant advantage in MIMO radars, through which, the system can achieve much better performance. Many different aspects of this performance improvement have been considered yet, and the transmit signals have been designed to attain such goal, e.g., getting higher SNR or better detector's performance at the receiver. However, an important tool for evaluating the radar's performance is its ambiguity function. In this paper, we consider the problem of transmit signal design, in order to optimize the ambiguity function...
Detection-localization tradeoff in MIMO radars
, Article Radioengineering ; Volume 26, Issue 2 , 2017 , Pages 581-587 ; 12102512 (ISSN) ; Radmard, M ; Chitgarha, M. M ; Bastani, M. H ; Nayebi, M. M ; Sharif University of Technology
2017
Abstract
Two gains play key roles in recently developed MIMO wireless communication systems: "spatial diversity" gain and "spatial multiplexing" gain. The diversity gain refers to the capability to decrease the error rate of the MIMO channel, while the multiplexing gain implicitly refers to the amount of increase in the capacity of the MIMO channel. It has been shown that there is a fundamental tradeoff between these two types of gains, meaning interplay between increasing reliability (via an increase in the diversity gain) and increasing data rate (via an increase in the multiplexing gain). On the other hand, recently, MIMO radars have attracted much attention for their superior ability to enhance...
Antenna placement and power allocation optimization in MIMO detection
, Article IEEE Transactions on Aerospace and Electronic Systems ; Vol. 50, Issue 2 , April , 2014 , pp. 1468-1478 ; Chitgarha, M. M ; Majd, M. N ; Nayebi, M. M ; Sharif University of Technology
2014
Abstract
It is a well known fact that using multiple antennas at transmit and receive sides improves the detection performance. However, in such multiple-input multiple-output (MIMO) configuration, proper positioning of transmitters and receivers is a big challenge that can have significant influence on the performance of the overall system. In addition, determining the power of each transmitter under a total power constraint is a problem that should be solved in order to enhance the performance and coverage of such a system. In this paper, we design the Neyman-Pearson detector under the Rayleigh scatter model and use it to introduce a criterion for the antenna placement at both transmit and receive...
Ambiguity function of MIMO radar with widely separated antennas
, Article Proceedings International Radar Symposium ; 16 -18 June , 2014 ; ISSN: 21555753 ; Chitgarha, M. M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
2014
Abstract
There has been much interest, recently, towards exploiting the Multiple-Input Multiple-Output (MIMO) technique in radar. It is shown that using multiple antennas at transmit and receive sides can improve the performance of the system. However, in order to analyze the system's performance, its ambiguity function, i.e. the ambiguity function of a MIMO radar, is needed to be defined. In this paper, beginning from the information theoretic definitions, we derive such function, specifically for a MIMO radar with widely separated antennas
Choosing the position of the receiver in a MISO passive radar system
, Article European Microwave Week 2012: "Space for Microwaves", EuMW 2012, Conference Proceedings - 9th European Radar Conference, EuRAD 2012 ; 2012 , Pages 318-321 ; 9782874870293 (ISBN) ; Majd, M. N ; Radmard, M ; Nayebi, M. M ; Sharif University of Technology
2012
Abstract
By combining the two ideas of MIMO (Multiple Input Multiple Output) and PCL (Passive Coherent Location) in radar, one can achieve the advantages of both recently developed techniques simultaneously. While using multiple antennas at the receive side provides a spatial diversity of the object to be detected, using multiple illuminators of opportunity, most importantly, makes the radar covert to the interceptors. One obstacle in such MIMO configuration is choosing the positions of the receive antennas. In this paper, after analyzing the Neyman-Pearson detector for the DVB-T based PCL, we introduce the probability of missed detection as a criterion to place the receive antenna. Here, we only...
Adaptive filtering techniques in passive radar
, Article Proceedings International Radar Symposium, Dresden ; Volume 2 , June , 2013 , Pages 1067-1078 ; 21555753 (ISSN) ; 9783954042234 (ISBN) ; Radmard, M ; Majd, M. N ; Nayebi, M. M ; Sharif University of Technology
2013
Abstract
One of the most important obstacles in passive radar applications is removing the direct signal from the target channel. Otherwise, week echoes from the targets in the target channel would be ignored due to the limited dynamic range of the system. One of the most effective techniques in this field is using adaptive filters. In this paper various adaptive filters are introduced and their performances are shown and compared
Ambiguity function based receiver placement in multi-site radar
, Article 2016 CIE International Conference on Radar, RADAR 2016, 10 October 2016 through 13 October 2016 ; 2017 ; 9781509048281 (ISBN) ; Chitgarha, M. M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
2017
Abstract
It has been shown that using multiple antennas in a radar system improves the performance considerably, since multiple target echoes are received from different aspect angles of the target. In this way, the target detection is improved. However, when using multiple antennas, some problems, such as designing the transmit signals, synchronization, etc. emerge that should be solved. One of such problems is the receiver placement. Receiver placement deals with choosing a proper position for the receive antenna in order to optimize the whole system's performance. In this paper, a receiver placement procedure based on improving the radar ambiguity function is proposed for the case of a multisite...
Improving MIMO radar's performance through receivers' positioning
, Article IET Signal Processing ; Volume 11, Issue 5 , 2017 , Pages 622-630 ; 17519675 (ISSN) ; Radmard, M ; Nazari Majd, M ; Nayebi, M. M ; Sharif University of Technology
Institution of Engineering and Technology
2017
Abstract
By employing the MIMO (multiple-input-multiple-output) technology in radar, some new problems emerged, that, in order to benefit the MIMO gains in radar, it was necessary to solve them suitably. One of such obstacles is determining the positions of receive antennas in a MIMO radar system with widely separated antennas (WS MIMO radar), since it is shown that the antennas' positions affect the whole system's performance considerably. In this study, a proper receivers' positioning procedure is proposed. To do this end, four criteria are developed based on the proposed MIMO detector and the MIMO ambiguity function. The simulations verify that the proposed positioning procedure improves the...
Silylation of hydroxy groups with HMDS under microwave irradiation and solvent-free conditions
, Article Phosphorus, Sulfur and Silicon and Related Elements ; Volume 177, Issue 2 , 2002 , Pages 289-292 ; 10426507 (ISSN) ; Saidi, M. R ; Bolourtchian, M ; Heravi, M. M ; Sharif University of Technology
2002
Abstract
Phenols and alcohols are silylated with hexamethyldisilazane (HMDS) under microwave irradiation in solvent-free condition in good to excellent yields
Dynamic analysis of carbon nanotubes under electrostatic actuation using modified couple stress theory
, Article Acta Mechanica ; Vol. 225, Issue 6 , June , 2014 , pp. 1523-1535 ; Online ISSN: 1619-6937 ; Rastgoo, A ; Ahmadian, M. T ; Mashhadi, M. M ; Sharif University of Technology
2014
Abstract
Modified couple stress theory is a size-dependent theorem capturing the micro/nanoscale effects influencing the mechanical behaviors of the micro- and nanostructures. In this paper, it is applied to investigate the nonlinear vibration of carbon nanotubes under step DC voltage. The vibration, natural frequencies and dynamic pull-in characteristics of the carbon nanotubes are studied in detail. Moreover, the effects of various boundary conditions and geometries are scrutinized on the dynamic characteristics. The results reveal that application of this theory leads to the higher values of the natural frequencies and dynamic pull-in voltages
White space regions
, Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 22 January 2011 through 28 January 2011, Novy Smokovec ; Volume 6543 LNCS , 2011 , Pages 226-237 ; 03029743 (ISSN) ; 9783642183805 (ISBN) ; Fazli, M ; Ghodsi, M ; Safari, M ; Saghafian, M ; Tavakkoli, M ; Sharif University of Technology
2011
Abstract
We study a classical problem in communication and wireless networks called Finding White Space Regions. In this problem, we are given a set of antennas (points) some of which are noisy (black) and the rest are working fine (white). The goal is to find a set of convex hulls with maximum total area that cover all white points and exclude all black points. In other words, these convex hulls make it safe for white antennas to communicate with each other without any interference with black antennas. We study the problem on three different settings (based on overlapping between different convex hulls) and find hardness results and good approximation algorithms
Utilization of hybrid nanofluids in solar energy applications: A review
, Article Nano-Structures and Nano-Objects ; Volume 20 , 2019 ; 2352507X (ISSN) ; Ghazvini, M ; Sadeghzadeh, M ; Alhuyi Nazari, M ; Ghalandari, M ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Hybrid nanofluids have several advantages compared with the conventional types due to their modified properties. Their enhanced thermophysical and rheological properties make them more appropriate for solar energy systems. In this review paper, an overview of solar energy systems is represented, and afterwards, applications of hybrid nanofluids in various solar technologies, especially solar thermal, are reviewed. Comparison between the nanofluidic systems, and the conventional ones is performed in order to gain a deeper insight into the advantages of using nanofluids. According to the results of the reviewed studies, the most important reason for performance enhancement of nanofluidic solar...
Investigating the temporal and spatial variations of water consumption in Urmia Lake River Basin considering the climate and anthropogenic effects on the agriculture in the basin
, Article Agricultural Water Management ; Volume 213 , 2019 , Pages 782-791 ; 03783774 (ISSN) ; Emadzadeh, M ; Gholizadeh, M ; Tajrishi, M ; Ahmadi, M ; Moradi, M ; Sharif University of Technology
Elsevier B.V
2019
Abstract
Urmia Lake River Basin (ULRB) is one of the most important habitats in the world and one of the major agricultural regions in Iran. On average, the ratio of irrigation to evapotranspiration in this basin is more than 73%. Investigating the irrigation water requirement pattern changes and the spatial distribution of evapotranspiration during the basin development period on a regional scale play important roles in understanding the basin situation. In this study, the actual evapotranspiration has been estimated by SEBAL model. By estimating the precipitation distribution in the basin, the agricultural irrigation water requirement pattern has been calculated using the land use map in 1995, 2010...
The first in situ synthesis of 1,3-dioxan-5-one derivatives and their direct use in Claisen-Schmidt reactions: Synthesis of dioxanones and their Claisen-Schmidt reactions
, Article Heterocyclic Communications ; Volume 25, Issue 1 , 2019 , Pages 85-90 ; 07930283 (ISSN) ; Mojtahedi, M. M ; Saeed Abaee, M ; Hashemi, M. M ; Sharif University of Technology
De Gruyter
2019
Abstract
A method is developed for in situ generation of 1,3-dioxan-5-one derivatives 2. These compounds are simple precursors for accessing carbohydrate structures and previously had to be produced via stepwise procedures using excessive amounts of reagents. In the present work, three different derivatives of 2 were synthesized via the reaction of trialkoxyalkanes with dihydroxyacetone dimer 1 in the presence of acetic acid as the catalyst. In the same pot, derivatives of 2 were reacted with aromatic aldehydes and 30 mol% of pyrrolidine to obtain high yields of the respective bischalcones 3 within short time periods. © 2019 M. Javad Poursharifi et al., published by De Gruyter 2019
Spatial multiplexing gain in MIMO radars with widely separated antennas
, Article IET Signal Processing ; Volume 12, Issue 2 , March , 2018 , Pages 207-213 ; 17519675 (ISSN) ; Radmard, M ; Chitgarha, M. M ; Farina, A ; Bastani, M. H ; Nayebi, M. M ; Sharif University of Technology
Institution of Engineering and Technology
2018
Abstract
Multiple-input multiple-output (MIMO) radars have attracted much attention for their superior ability to enhance a system's performance. In this study, the authors' goal was the study of the spatial multiplexing gain of MIMO radars with widely separated antennas (WS-MIMO), which the authors showed that is equal to the number of unambiguously detectable targets. They obtained this number from two different aspects: first, by defining the ambiguity function of a WS-MIMO radar in the case of multiple targets, suitable for such purpose; Second, by modelling the MIMO radar system with a MIMO wireless channel. They showed that a MIMO radar is indeed a MIMO wireless system communicating the...