Loading...

Boosting bone cell growth using nanofibrous carboxymethylated cellulose and chitosan on titanium dioxide nanotube array with dual surface charges as a novel multifunctional bioimplant surface

Rahnamaee, S.Y ; Sharif University of Technology | 2023

0 Viewed
  1. Type of Document: Article
  2. DOI: 10.1016/j.ijbiomac.2022.12.159
  3. Publisher: Elsevier B.V , 2023
  4. Abstract:
  5. One of the most vital aspects of the orthopedic implant field has been the development of multifunctional coatings that improve bone-implant contact while simultaneously preventing bacterial infection. The present study investigates the fabrication and characterization of multifunctional polysaccharides, including carboxymethyl cellulose (CMCn) and carboxymethyl chitosan nanofibers (CMCHn), as a novel implant coating on titania nanotube arrays (T). Field emission scanning electron microscopy (FESEM) images revealed a nanofibrous morphology with a narrow diameter for CMCn and CMCHn, similar to extracellular matrix nanostructures. Compared to the T surface, the roughness of CMCn and CMCHn samples increased by over 250 %. An improved cell proliferation rate was observed on CMCHn nanofibers with a positively charged surface caused by the amino groups. Furthermore, in an antibacterial experiment, CMCn and CMCHn inhibited bacterial colony formation by 80 % and 73 %, respectively. According to the results, constructed modified CMCn and CMCHn increased osteoblast cell survival while inhibiting bacterial biofilm formation owing to their surface charge and bioinspired physicochemical properties. © 2022 Elsevier B.V
  6. Keywords:
  7. Carboxymethyl ; Cellulose ; Chitosan ; Nanofibers ; Orthopedic implant ; Titania nanotube
  8. Source: International Journal of Biological Macromolecules ; Volume 228 , 2023 , Pages 570-581 ; 01418130 (ISSN)
  9. URL: https://www.sciencedirect.com/science/article/abs/pii/S0141813022030677