Sharif Digital Repository

Genetic heterogeneity within a tumor, which occurs during cancer evolution, is one of the reasons for treatment failure and increased chances of drug resistance. Cancer cells initially derive from a mutated progenitor cell, resulting in shared mutated genes. Throughout the course of tumor formation and progression, the occurrence of new mutations is possible, leading to the generation of cancer cells with various mutated genes. An appropriate approach is to identify the sequence of mutations that have occurred in the tumor, which can be inferred from single-cell sequencing data. Singlecell data provides valuable information about branching events in the evolution of a cancerous tumor. In... 

Occurrence of scouring around the seabed pipelines can lead to pipe failure and pose a serious threat to the marine environment, economic losses and waste of oil and gas. Therefore, to prevent the occurrence of scouring, by simulating this phenomenon and identifying the parameters affecting it, we can help to design a more efficient placement of pipes in the seabed. Various methods such as potential flow theory and turbulent single-phase and two-phase models have been proposed to simulate this phenomenon. The purpose of this article is to simulate and investigate the effective parameters of this phenomenon by combining computational fluid dynamics and separate elements. The innovation of... 

Based on the importance of DNA/RNA binding proteins in different cellular processes, finding binding sites of them play crucial role in many applications, like designing drug/vaccine, designing protein, and cancer control. Many studies target this issue and try to improve the prediction accuracy with three strategies: complex neural-network structures, various types of inputs, and ML methods to extract input features. But due to the growing volume of sequences, these methods face serious processing challenges. So, this paper presents KDeep, based on CNN-LSTM and the primary form of DNA/RNA sequences as input. As the key feature improving the prediction accuracy, we propose a new encoding... 

Creating any project requires investment, time, and resources. Many construction projects have failed despite considerable money invested in them. A common cause of this failure is improper planning. One of the most important parts of project planning is the feasibility study which is missing in many projects in Iran. However, the fundamental reasons that prevent construction project managers and owners from efficiently performing feasibility studies in their projects have not been investigated in the country yet. In this study, we aim to evaluate this aspect of the construction projects in the country by investigating the structure of feasibility studies in the building construction... 

The first step in improving traffic safety and reducing damage to road users is to evaluate traffic safety and identify black spots, which is possible in statistics-based methods using traffic accident data from previous years. One of the disadvantages of statistical methods is the existence of a series of limitations in collecting accident data and spending a lot of time and money. The purpose of this research is to provide a technique to evaluate traffic safety and estimate the number of accidents using the traffic conflict technique and extreme value theory modeling. The method of conducting this research is based on image processing, recording, and analysis of the conflict index of two... 

Speech synthesis and its applications have been very attractive recently. The main purpose of this technique is to produce a speech signal with natural characteristics of human speech like prosody and emotion. Among all existing methods for speech synthesis, statistical parametric speech synthesis methods are more promising because ofhigher flexibility in comparison to other methods. One of the applications of speech synthesis is speech to speech translation. In these systems, the generated voice in target language should have the same characteristics as the input voice in source language. The main purpose of this research is to review and evaluate the cross lingual speaker adaptation... 

Surface piercing propellers are particular type of supercavitating propellers that are commonly used for High-speed vessels. Most studies on this type of propellers has been investigating the hydrodynamic forces. But in recent years with increase in SPPs diameter used in vessels, structural analysis of this type of propellers is considered. For this purpose, studies on the stresses exerted on the propeller structures under load is done with the help of Hydro elastic methods. In this type of analysis, structura of propeller is intended to be flexible and Displacements under pressure checked and Tensions resulting from it are studied.
The present Thesis using ANSYS software to analyze a... 

Pricing plays an important and essential role in the profit and income of companies. The importance of pricing is not only related to its role in the company's profitability, but it also changes the customer's understanding and loyalty towards the company and can create the company's reputation or destroy it. Determining the right price will increase product sales and increase customer loyalty and create a competitive advantage for the company. One of the most important and influential variables in product pricing is the amount of demand. The main challenge of companies for product pricing is the uncertainty in their demand. In order to deal with this problem, data-driven pricing is used.... 

The increasing demand for autonomous vehicles and reliable communication protocols and hardware interfaces, such as CAN bus and USB, underscores the necessity for stable clock sources that maintain a low temperature coefficient (TC) over wide temperature ranges. This demand is particularly emphasized in applications such as wearables, network sensors, downhole devices, WSNs, and IoT, where long-lasting battery life and frequency-stable clock sources over a broad temperature range (e.g. -20 °C to 100 °C) are crucial. Traditionally, variations in frequency caused by temperature have been mitigated by employing off-chip components like crystals or ceramic based oscillators, but this approach... 

The increasing demand for communication bandwidth and limited spectrum availability have heightened the complexity of radio front-end circuits in IoT applications. Achieving spectral efficiency is a key challenge, particularly for IoT devices operating at specific frequency bands such as 315 MHz, 433 MHz, 868 MHz, and 915 MHz.Due to the limited linearity of the transmit path, harmonic distortion components, known as counter intermodulation (CIM) products, are generated. These CIM products can directly fall into the receiver (RX) band or enter it via cross-modulation, thereby degrading the frequency division performance. Additionally, CIM products can interfere with protected bands, violating... 

Autonomous vehicles, as an integral part of intelligent transportation systems, will play a significant role in the future of transportation services. These vehicles have a high potential to improve road traffic capacity and the efficiency of transportation systems. One type of autonomous vehicle is the connected and autonomous vehicle (CAV), which can communicate with each other, roadside units, traffic control signals, and other infrastructures or devices. This study investigates the impact of autonomous vehicles and connected and autonomous vehicles on the traffic flow of the Tehran-Karaj freeway and vice versa, under various penetration rates and in a mixed traffic environment. In this... 

The Bullwhip effect is a phenomenon that refers to the amplification of demand variance as one moves upstream in a supply chain. This effect imposes additional costs on the supply chain and complicates inventory planning. Several factors contribute to the emergence of this phenomenon, one of which is demand forecasting. Since the demand faced by each level of the supply chain is uncertain, every level must first forecast demand in order to plan its inventory and meet customer requirements. However, this very process of forecasting contributes to the bullwhip effect. In this study, we investigate the impact of machine learning and deep learning forecasting methods, along with their... 

Sensor Observation Service (SOS) which is defined by Open Geospatial Consortium (OGC) Sensor Web Enablement group is a Web service specification in order to standardize the way sensors and sensor data are discovered and accessed on the Sensor Web. Multiple instances of this service can be implemented around the world, providing huge amount of data every moment. Each of these services operates in specific domain of knowledge (thematic), spatial and temporal dimensions. One way to reveal the underlying data over all of them is to provide an architecture for data integration to allow the user to query sensor data without the knowledge of the infrastructure components. In this research, a novel...