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    Fabricate of Novel Drug Vector Based on Metallic Nanoparticles and Study of its Effects on Cell Line

    , Ph.D. Dissertation Sharif University of Technology Asadishad, Bahareh (Author) ; Vosoughi, Manouchehr (Supervisor) ; Alemzadeh, Iran (Supervisor)
    Abstract
    Application of nanoparticles in targeted delivery and controlled drug release is recently highly attracted especially in cancer therapy. In this study with the aim of developing a novel drug vector based on metallic nanoparticles, gold nanoparticles with their unique characteristics were used to design a vector for targeted anti-cancer drug delivery to tumor. First, gold nanoparticles were chemically synthesized therough sodium citrate and sodium brohydrate reductions with average diameters of 22 and 11 nm, respectively. Then, the activated poly ethylene glycol (PEG) and activated folic acid were conjugated to the lysine-capped gold nanoparticles. Subsequently, the widely used anticancer... 

    Synthesis of Dextran-MA-Gly-Gly-NHNH2 Copolymer as a Possible Biodegradable and pH-responsive Carrier for Doxorubicin

    , M.Sc. Thesis Sharif University of Technology Emami, Zahraosadat (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    Some chemotherapy drugs have unpleasant side effects and use them due to the instability and low solubility in blood flow is associated with problems and limitations.To solve these problems, controlled drug delivery systems have been proposed. In this process, the polymer increased solubility, stability and low toxicity and the active drug realease in a particular tissue or controlled speed. Therefore be less adverse side effects. Dextran is the one of biocompatible and water-soluble polysaccharides that due to its unique characteristics, widely used as carriers in drug delivery. Dextran molecules can bind to drugs and increased solubility, stability, and reduce their side effects.... 

    Synthesis of Pyrene-Based Supramolecular Nanomaterials and Investigation of its Cellular Toxicity of Antitumor and Activities

    , M.Sc. Thesis Sharif University of Technology Eskandari, Mohammad (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    In this work, pH sensitive supramolecular shuttles consisting of carbon nanotube-graft-pyrene (CNT-graft-PYR) and hyperbranched polyglycerol with β-cyclodextrin core (β-CD-graft-PG) were synthesized and characterized. Supramolecular systems (PG/CNT/S) were able to load and transport doxorubicin in aqueous solutions. While PG/CNT/S were soluble in phosphate buffer pH 7, they were divided to their individual moieties in pH 5 and therefore CNTs containing staked doxorubicin molecules were precipitated  

    The Effect of Protein Corona on Doxorubicin Release from the Magnetic Mesoporous Silica Nanoparticles and the Effect of Polyethylene Glycol Coating on drug Delivery System

    , M.Sc. Thesis Sharif University of Technology Mahmoudi, Negar (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    The nanoparticles have been widely used in the field of physics, chemistry, electronics and mechanics because of their high surface area. One of their most important applications is in drug delivery systems as smart drug nanocarrier. Magnetic nanoparticles (including Fe2O3, Fe3O4) are the good candidates for this purpose. It is clear that, upon to entrance of nanoparticle into biological media (such as plasma), the surface of nanoparticles were covered by protein layers (protein corona). This layer is very stable and created new surface on the nanoparticles. The protein corona layer intracts with cellular receptors and determines the fate of nanoparticles. Protein corona covers the targeting... 

    Magnetic Nanocomposites Based on Bio-Degradable Polylactic Acid

    , M.Sc. Thesis Sharif University of Technology Shamshiri, Soodeh (Author) ; Frounchi, Masoud (Supervisor)
    Abstract
    In this work, magnetite (Fe3O4) nanoparticles with an average siz21.9nm
    modified by oleic acid were prepared by the coprecipitation method, which can linked well with organic molecules because of the presence of C-O-C on their surface. Then magnetic poly(lactic acid) (PLA)/ poly(ethylene glycol) (PEG) microspheres were prepared by the single emulsion solvent evaporation technology. The incorporation of magnetit nanoparticles and dox into the PLA matrix was confirmed by FTIR. XRD and VSM confirmed the existence of MNPs in the microspheres which maintained superparamagnetic behavior with a saturation magnetization of 50.69 emu/g.Electron microscopy SEM showed that the magnetic microspheres... 

    Preparation of Graphene Oxide Magnetic Nanoparticles with Mesoporous Silica Layer, Coating with pH-Sensitive Polymer as Nanocarriers of Anticancer Drugs

    , M.Sc. Thesis Sharif University of Technology Shakerpoor, Alireza (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    Man’s struggle for optimization in different areas has been an endless one. Optimizing methods of cancer treatment is not an exception. Because of numerous side effects of anti-cancer drugs, drug delivery systems (DDS) have been recently given much interest. Considering some aspects, DDS are helpful in reducing harmful effects of anti-cancer drugs and more efficient healing by these drugs: first by reducing the dosage of drug by controllable and sustainable release of drug in a kinetic (diffusion) pattern; second by smart release of drug in target tissue which in turn protects sound tissues not to be in contact with drug.In this study, three kinds of nanoparticles have been used for DDS... 

    Loading of Doxorubicin on Stimuli-Responsive Nanocarriers and Investigation of its Release

    , M.Sc. Thesis Sharif University of Technology Yaghoubi, Mahshid (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    Drug targeting to specific organs and tissues has become one of the critical endeavors of the new century. Magnetic nanoparticles have gained a lot of attention in biomedical and industrial application. Doxorubicin is an effective anti-cancer drug in the treatment of many types of cancers. The aim of this study is to load doxorubicin on stimuli-responsive nanocarriers. These nanocarriers are prepared from magnetic nanoparticles. Then these magnetic nanparticles are coated by copolymer of poly(glycidyl methacrylate) then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This... 

    Surface Modification and Stabilization of TiO2 Nanoparticles for Sonodynamic Therapy

    , M.Sc. Thesis Sharif University of Technology Younesi, Hamid (Author) ; Maddah Hosseini, Hamid Reza (Supervisor)
    Abstract
    Sonodynamic therapy has been developed over the last century, now it has become more widely used as a medical tool for the treatment of various diseases such as cancer. This technique involves delivery of sonosensitizing drugs, irradiation of ultrasound waves and motivation of drugs. In this thesis surface modification process with polymer and biocompatible surfactant on TiO2 nanoparticles has been done due to stabilization of TiO2 nanoparticles in neutral pH which is similar to inside-body situation. In the last step, for cancer therapy, doxorubicin as a cancer drug was loaded on TiO2 which was surface modified by PVA. The results revealed the best ratio of (PVA: TiO2), (SDS: TiO2), (SDS:... 

    Synthesis of Magnetic Nanocarriers Based on Coating of Fe3O4 with Modified Biodegradable Polysaccharides by pH Sensitive Agents for Targeted Release of Anticancer Drug Doxorubicin

    , M.Sc. Thesis Sharif University of Technology Amin, Shiva Sadat (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    One of the major problems in cancer treatment is the side effects of the drugs. Nowadays, scientists are developing smart nanocarriers which used for diagnosis and delivering drugs in order to circulate through blood vessels, pass the immune system, attach to cancer cells and kill them without any side effects. In the first research of this thesis, magnetic nanoparticles were coated by modified alginate and used as smart nanocarriers. Magnetic nanocarrier were sysnthesized based on hydrophobic coating of oleic acid and hydrazine oleate-modified alginate shell. The resulting carrier is pH-sensitive and the alginate shell removes in the low pH medium. DOX was placed between hydrophobic chains.... 

    Preparation and Evaluation of Doxorubicin-loaded Fe3O4\Chitosan Magnetic Nanocomposite for Drug Delivery System in Cancer Therapy

    , M.Sc. Thesis Sharif University of Technology Tajeri, Razieh (Author) ; Maddah Hosseini, Hamid Reza (Supervisor)
    Abstract
    Recent drug delivery strategies have attempted to maximize the concentration of chemotherapeutic molecules into the tumors, while minimizing their systemic distribution. Doxorubicin has been widely used for a variety of cancers, successfully producing regression in acute leukaemia, lymphomas, soft-tissue and osteogenic sarcomas, paediatric malignancies and adult solid tumours, in particular breast and lung carcinomas. Common adverse effects of doxorubicin include hair loss, myelosuppression, nausea and vomiting, oral mucositis, oesophagitis, diarrhoea, skin reactions and serious reactions include hypersensitivity reactions, radiation recall, heart damage and liver dysfunction. Chitosan has... 

    PEG-PLA-Polysccharide Injectable Nanogels for Drug Delivery

    , M.Sc. Thesis Sharif University of Technology Zeraatkar, Ehsan (Author) ; Frounchi, Masoud (Supervisor) ; Dadbin, Sousan (Supervisor)
    Abstract
    In recent years along with time and cost intensive process of developing new and better drugs for diseases like cancer, scientists and researchers are attempting to develop novel drug delivery systems for already existing drugs.The purpose of these novel drug delivery systems such as nanogels is controlling drug release rate as well as delivery to a specific target tissue in order to reduce side effects. One of the most commonly used drugs for cancer treatment is Doxorubicin HCl, commercially known as Adricin. In this project biodegradable and biocompatible polymers PLA and PEG were used to synthesize nanocarriers for Adricin. These nanocarriers were then dispersed in an agar hydrogel. The... 

    Synthesis and Characterization of Polymeric Nanocomposites Via Reversible Addition−Fragmentation Chain-Transfer (RAFT) Polymerization and Investigation of their Applications

    , M.Sc. Thesis Sharif University of Technology Kohestanian, Mohammad (Author) ; Pourjavadi, Ali (Supervisor)
    Abstract
    In this thesis, nanocomposites based on magnetic graphene oxide and iron oxide nanoparticles coated with smart polymeric materials (by polymerization of monomers such as glycidyl methacrylate, acrylic acid, and N-isopropyl acrylamide) via Reversible Addition−Fragmentation Chain-Transfer (RAFT) polymerization were successfully synthesized. The combination of large surface area in nanoparticles and different functional groups in polymeric layers can give unique properties to nanocomposites. Therefore, we synthesized various smart nanocomposites with this perspective. After synthesizing these nanocomposites, smart magnetic nanoparticles were characterized by FT-IR, NMR, XPS, TGA, DLS, VSM, GPC,... 

    Synthesis, Characterization and Application of Inorganic Nanosystems based on Biocompatible and Highly Tunable Materials for Targeted Delivery and Release of Gene and Drug

    , Ph.D. Dissertation Sharif University of Technology Rabiee, Navid (Author) ; Bagherzadeh, Mojtaba (Supervisor)
    Abstract
    In this dissertation, an attempt has been made to prepare a library from most of the inorganic and organic compounds in order to strengthen the use of nanosystems for the purpose of controlled delivery and release of drugs and genetic material. In this regard, a complete set of compounds based on metal nanoparticles, layered double hydroxides, metal-organic frameworks, graphene oxide and carbon nanotubes were designed, synthesized and characterized, and nanocomposites and hybrids of them based on palladium, zinc, copper and nickel were designed as well. The nano-stable system is designed with positive surface potential, very low cytotoxicity, biodegradability and acceptable environment as... 

    Synthesis and Characterization of Transition Metal Complexes Supported on Carbon-Based Nanocomposites and Their Application as Gene and Drug Delivery Systems

    , Ph.D. Dissertation Sharif University of Technology Safarkhani, Moein (Author) ; Bagherzadeh, Mojtaba (Supervisor)
    Abstract
    In this dissertation, an attempt has been made to optimize some smart nanocarriers and the controllable release of drug (doxorubicin) and genetic material (plasmid CRISPR). Regarding, some metal nanoparticles, metal-organic frameworks, transition metal complexes, graphene oxide, and functionalized carbon nanotubes have been synthesized and also characterized and their hybrids and nanocomposites have been prepared successfully. All the abovementioned nanomaterials were designed and synthesized due to achieve biodegradable, biocompatible, higher positive surface potential, lower cytotoxicity, better responsivity to stimulus, and greener compounds. Doxorubicin and plasmid CRISPR has been... 

    Improving the Biomedical Performance of Metal–Organic Frameworks in Drug Delivery Systems: in Vitro Studies

    , M.Sc. Thesis Sharif University of Technology Bahmanpour, Maryam (Author) ; Bagherzadeh, Mojtaba (Supervisor)
    Abstract
    In this study, water-stable metal-organic frameworks, UiO-66-(CO2H)2, MIL-53-NH2 (Al), ZIF-8 and MIP-202 (Zr), were selected to study the influence of using plant extracts in drug loading process and also its targeted release from these compounds. For this purpose, at first the solution of different plant extracts was used separately as a synthetic solvent in the preparation of the desired MOFs to be present in the structure of these compounds and increase the interaction of the drug with the nanocarrier. Then, a coating of plant extract was applied on the nanocarrier containing the drug after loading the drug to prevent the rapid penetration of the drug from the cavities of MOFs (drug... 

    Green Synthesis, Characterization and Application of the Nanomaterials Based on Aluminum Fumarate Metal-Organic Frameworks for Targeted and Smart Delivery and Release of Doxorubicin

    , M.Sc. Thesis Sharif University of Technology Abbariki, Nikzad (Author) ; Bagherzadeh, Mojtaba (Supervisor)
    Abstract
    In this research, an attempt was made to increase the efficiency and effectiveness of the targeted and controlled release systems of the anticancer drug (doxorubicin) by using inorganic and organic compounds as well as inorganic-organic hybrids. For this purpose, a whole class of aluminum fumarate metal-organic frameworks-based and reduced-graphene oxide nanocarriers were synthesized and using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction spectroscopy (XRD), scanning electron microscope (FESEM) and atomic force microscope (AFM) analysis were characterized, and their nano-composites based on organotin-complexes with the approach of achieving a stable drug delivery system,... 

    A Heart-On-A-Chip Platform Containing Channeled Hydrogel for Drug Testing

    , M.Sc. Thesis Sharif University of Technology Abdi, Azadeh (Author) ; Mashayekhan, Shohreh (Supervisor)
    Abstract
    Cardiovascular diseases are one of the leading causes of death worldwide. Despite significant advances in therapeutic interventions for these diseases, the pathophysiology remains incompletely understood. Challenges in drug evaluation include the lack of appropriate clinical trials, such as conventional 2D cell cultures and animal studies, as well as the absence of model systems that can provide complex and patient-specific cardiac functions for diagnosis. Organ-on-a-chip devices have the potential to mimic the body's response to treatments by utilizing microscale cell culture fluid connections and creating realistic models of human organs of interest. Our objective is to develop a...