Sharif Digital Repository

Abnormality detection and prognosis of epileptic patients with artificial intelligence and machine learning techniques is still in its early experimental stages. Surgical candidacy determination for epilepsy depends on the clinical actions which involve an intracranial electrode implantation followed by prolonged electrographic monitoring (EEG phase II) .This invasive test is very costly, painful and time consuming. Here the goal is integration of the two following paradigms: 1-Non invasive multimodality data of epilepsy. 2- Artificial intelligence and machine learning techniques. We have used human brain multi-modality database system that includes patient’s demographics, clinical and EEG... 

In this thesis, the efficiency of bump modeling has been investigated on brain signals, in a variety of aspects including analysis, detection, classification and prediction. The aim of bump modeling is to provide an optimized representation of the signal in time-frequency domain. This would be done by discriminating oscillatory bursts from background signal and then showing them by half-ellipsoid functions called bump. Consequently, the problem of dealing with large numbers of parameters and hence complicated calculations, which are serious concerns in similar methods, can be overcome. This is in addition to the benefits of using time-frequency representation of the signal.The aim of bump... 

After Alzheimer and brain attack, the most common neurological disorder is epilepsy, which often involves seizures. In two-thirds of patients with epilepsy, the seizures can be controlled by antiepileptic drugs, and about 8% of patients can use epilepsy surgery; but unfortunately there is no acceptable treatment for the other 25% of these patients. Therefore preventing from epilepsy losses is a very important topic.
The gold standard for the diagnosis of the epilepsy is EEG monitoring. In this method, electrodes are placed on the scalp. Electrodes are uncomfortable to wear, and cause invasion to the patient, hence long-term monitoring and home monitoring is not feasible. In some... 

Complex systems are composed of a large number of subsystems behaving in a collective manner. In such systems, which are usually far from equilibrium, collective behavior arises due to self-organization and results in the formation of temporal, spatial, spatio-temporal and functional structures. The dynamics of order parameters in complex systems are generally non-stationary and can interact with each other in nonlinear manner. As a result, the analysis of the behavior of complex systems must be based on the assessment of the nonlinear interactions, as well as the determination of the characteristics and the strength of the fluctuating forces. This leads to the problem of retrieving a... 

This thesis presents my Ph.D. research study focusing on the dynamic analysis of magnetic nanoparticles (MNPs) for epilepsy and blood-brain barrier (BBB) applications. In this analysis, we took into account various parameters including the magnetic field, fluid behavior, geometry and material of MNPs. Based on this computational study, the generated magnetic field in epileptic foci results in the aggregation of nanoparticles. This may offer the advantage of using MNPs as a Magnetic Resonance Imaging (MRI) contrast agent. Furthermore, in this study, we also demonstrated and discussed the advantage of MNPs for crossing BBB using the external magnetic field. The outcome of this research project... 

Epilepsy is one of the diseases that affects the quality of life of epileptic patients. Epileptic patients lose control during epileptic seizures and are more likely to face problems. Designing and creating a seizure detection system can reduce casualties from epileptic attacks. In this study, we present an automatic method that reduces the artifact from the raw signals, and then classifies the seizure and non-seizure epochs. At all stages, it is assumed that no information is available about the patient and this detection is made only based on the information of other patients. The data from this study were recorded in Temple Hospital and the recording conditions were not controlled, so... 

Epilepsy is a chronic neurological disorder characterized by recurrent and abrupt seizures. Seizures occur due to disturbances in the interactions between the distributed neuronal populations in the brain. Investigation of the brain functional connectivity networks is a way to better understand how the brain functions during seizure. To estimate the brain functional connectivity network, we need criteria that can estimate the functional connections between the brain regions from the recorded brain functional data such as electroencephalogram (EEG) signals. After estimating the functional brain connectivity networks, it is possible to create graphs corresponding to these estimated networks... 

The prevalence of epilepsy in the world and the need for surgery to treat patients have made it essential to locate the site of epilepsy before surgery. One method is to apply source localization algorithms to the EEG signals of epileptic patients in the ictal and interictal periods. However, because these signals are contaminated with various noises, they are challenging to interpret and require noise cancellation. Therefore, various methods have been proposed to eliminate the noise. Among these methods, a new method recently used to remove noise from the epileptic signal is Morphological Component Analysis (MCA). This method uses the basic concepts of sparse representation of signals to... 

Epilepsy is one of the most common non-communicable neurological disorders, characterized by recurrent seizure symptoms. Although much progress has been made in the diagnosis, control, and treatment of epilepsy in recent years, the exact mechanism of seizures, the specific method for early diagnosis of epilepsy and related syndromes, and definitive treatment for all patients are not yet known. In a type of seizure known as focal seizure, the electrical activity of neurons at the epilepsy focus synchronizes abnormally, and this synchronization can propagate to other regions of the brain in a process called secondary generalization, which finding a method for its prevention is our essential goal... 

The processing of brain signals, including the electrocorticogram (ECoG) signal, is widely used in the investigation of neurological diseases. Conventionally, the ECoG signal has frequency components up to the range of 80 Hz. Studies have proven that in some conditions, such as epilepsy, the brain signal includes frequency components higher than 80 Hz, which are called high-frequency oscillations (HFO). Therefore, HFOs are recognized as a biomarker for epilepsy. The aim of this thesis is to review the previous methods of detecting HFOs and to present new methods with greater efficiency in the direction of diagnosis or treatment of epileptic patients. For this purpose, we used the ECoG data... 

Centuries passed and the human knew himself as the protagonist who searches around nature and discovers the phenomena. But after the birth of ``neuroscience", his wisdom and the process of reasoning were also added to the list of uncovered subjects. Since its arrival, many scientists started investigating ``reasoning", "sleep", ``memory disorders" etc. with a such framework. One of the main branches of this stream is the ``Synchronization" problem when the neurons get synced in the matter of spiking likelihood. ``Synchronization" means a lot to the community, because it is said that it is one major symptom of Epilepsy. With that said, we need to get to the root of this effect. It seems... 

In most of brain studies, the primary objective is to find dipole activities, an underdetermined problem that requires additional constraints. Adequate constraints can be added by using information from other modalities. This research aims to develop a platform that combines various noninvasive modalities to improve localization accuracy. To accomplish this, two novel general approaches to combining modalities are proposed. In the first approach, the result of localizing by different methods and in different modalities are processed and combined in intervals by Dempster Shaffer's combination law. The final amount of bipolar activity is obtained by cumulating the activities obtained at...