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Signal Subspace Identification for Epileptic Source Localization from EEG Data

Hajipour Sardouie, Sepideh | 2014

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  1. Type of Document: Ph.D. Dissertation
  2. Language: English
  3. Document No: 46690 (05)
  4. University: Sharif University of Technology; University of Rennes 1, France
  5. Department: Electrical Engineering
  6. Advisor(s): Shamsollahi, Mohammad Bagher; Albera, Laurent; Merlet, Isabelle
  7. Abstract:
  8. In the process of recording electrical activity of the brain, the signal of interest is usually contaminated with different activities arising from various sources of noise and artifact such as muscle activity. This renders denoising as an important preprocessing stage in some ElectroEncephaloGraphy (EEG) applications such as source localization. In this thesis, we propose six methods for noise cancelation of epileptic signals. The first two methods, which are based on Generalized EigenValue Decomposition (GEVD) and Denoising Source Separation (DSS) frameworks, are used to denoise interictal data. To extract a priori information required by GEVD and DSS, we propose a series of preprocessing stages including spike peak detection, extraction of exact time support of spikes and clustering of spikes involved in each source of interest. Two other methods, called Time Frequency (TF)-GEVD and TF-DSS, are also proposed in order to denoise ictal EEG signals for which the time-frequency signature is extracted using the Canonical Correlation Analysis method. We also propose a deflationary Independent Component Analysis (ICA) method, called JDICA, that is based on Jacobi-like iterations. Moreover, we propose a new direct algorithm, called SSD-CP, to compute the Canonical Polyadic (CP) decomposition of complex-valued multi-way arrays. The proposed algorithm is based on the Simultaneous Schur Decomposition (SSD) of particular matrices derived from the array to process. We also propose a new Jacobi-like algorithm to calculate the SSD of several complex-valued matrices. The last two algorithms are used to denoise both interictal and ictal data. We evaluate the performance of the proposed methods to denoise both simulated and real epileptic EEG data with interictal or ictal activity contaminated with muscular activity. In the case of simulated data, the effectiveness of the proposed algorithms is evaluatedin terms of Relative Root Mean Square Error between the original noise-free signals and the denoised ones, number of required flops and the location of the original and denoised epileptic sources. For both interictal and ictal data, we present some examples on real data recorded in patients with a drug-resistant partial epilepsy
  9. Keywords:
  10. Electroencphalogram Signal ; Epilepsy ; Noise Removing ; Ictal Signals ; Interictal Signals

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