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Synthesis of Nano Ceramic Powders for Drug Delivery and It’s Release

Shahriari, Rezvan | 2010

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 41299 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Nemati, Ali; Dobakhti, Faramarz
  7. Abstract:
  8. In this project, Fe3O4 nanoparticles were synthesized and coated with different polymeric materials for drug delivery application. For this purpose, water dispersible oleic acid(OA)- pluronic block copolymer coated magnetite iron oxide nanoparticles were synthesized that can be loaded with proper doses of cephalexin. Our data indicated that formulation of iron oxide nanoparticles was developed by optimizing the amount of oleic acid required to coat iron oxide nanoparticles and then by optimizing the amount of pluronic required to form an aqueous dispersion of oleic acid coated nanoparticles. Synthesis of magnetite nanoparticles was done by the addition of a strong base (NH4OH) to ferrous chloride solution. Magnetic Measurement ssuggest that OA-coated iron-oxide nanoparticles tend to aggregate. Pluronic decreases aggregation, improves the stability of the suspension in water and increases blood circulation time. Cephalexin was used as a model drug for incorporation in nanoparticles. Our results showed that cephalexin loading on the nanoparticles was about 43 percent. Drug release determinations were conducted and the obtained showed that release of about 90 percent of loaded drug took place within 6 hours
  9. Keywords:
  10. Magnetic Nanodot ; Magnetite ; Oleic Acid ; Drug Delivery ; Drug Release ; Drug Carrier ; Pluronic

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