Experimental Study of the β-CD-g-PG Hybrid Nanostructure On Phase Solubilityof Hydrophobic Drug

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Asadi, Farshid | 2011

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 42064 (06)
University: Sharif University of Technology
Department: Chemical and Petroleum Engineering
Advisor(s): Saifkordi, Aliakbar; Vossoughi, Manouchehr
Abstract:
Some widely used drugs such as paclitaxel (PTX) are poorly water soluble. The clinical use of PTX with solubilizer causes side effects. These problems limited its application in treatments. In this work has been studied the effect of β-CD-g-PG (HPCD) hybrid nanomaterials, conjugated PG branches onto β-CD core, on the water solubility of PTX. First HPCD has been synthesized. Then the inclusion complex of PTX with HPCD was prepared. The inclusion complex efficiency for PTX:HPCD complex in 1:25 mole ratio was 87%. Then solubility of PTX with HPCD in water has been determined, showing Ap type phase solubility diagram. Then stability constants were calculated. The first order and second order stability constants for inclusion complex in 25˚C were 3.33 M-1 and 1801.54 M-1, respectively. Therefore, obtained results show that HPCD, lead to water solubility enhancement of PTX
Keywords:
Nanostructure ; Solubility ; Beta-Cyclodextrin ; Pacli Taxel (PTX) ; Inclusion Complex

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