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Synthesis of Pyrene-Based Supramolecular Nanomaterials and Investigation of its Cellular Toxicity of Antitumor and Activities

Eskandari, Mohammad | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 45005 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. In this work, pH sensitive supramolecular shuttles consisting of carbon nanotube-graft-pyrene (CNT-graft-PYR) and hyperbranched polyglycerol with β-cyclodextrin core (β-CD-graft-PG) were synthesized and characterized. Supramolecular systems (PG/CNT/S) were able to load and transport doxorubicin in aqueous solutions. While PG/CNT/S were soluble in phosphate buffer pH 7, they were divided to their individual moieties in pH 5 and therefore CNTs containing staked doxorubicin molecules were precipitated
  9. Keywords:
  10. Doxorubicin ; Drug Delivery ; Anticancer Drugs ; Cytoxicity ; Carbon Nanotubes

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