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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 45335 (06)
- University: Sharif University of Technology
- Department: Chemical and Petroleum Engineering
- Advisor(s): Shahrokhi, Mohammad
- Abstract:
- In this thesis, simulation and control of intracranial pressure and temperature has been studied. Common methods for control of intracranial pressure and temperature are hypothermia treatment and drug therapy. Hypothermia is a clinical treatment for cooling the patient body with cold water-circulating blanket to decompress intracranial pressure by decreasing body temperature. In order to simulate the patient body, two mathematical models for single-input single-output and multi-input multi-output systems that are proposed in the literature are chosen. The thermodynamic- hemodynamic model was simulated as single-input single-output system and the thermodynamic- hemodynamic- pharmacokinetic model was simulated as multi-input multi-output system.Two linear models were identified for the above systems using least squares method. Identified linear models after validation were used for model predictive controller design. Finally the performance of the designed predictive controllers were investigated for set point tracking, load rejection and model mismatch and compared with those of proportional-integral-derivative controllers proposed in the literature. The results of comparisons confirm advantage of predictive controller, although predictive controller has higher computational load
- Keywords:
- Intracranial Pressure ; Predictive Control ; Intracranial Temperature ; Hypothermia ; Thermodynamic-Hemodynamic Model ; Thermodynamic-Hemodynamic-Pharmacokinetic Model
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