One-pot diastereoselective synthesis of α-aminonitriles from aldehydes, chiral amines, and trimethylsilyl cyanide under solvent-free conditions [electronic resource]

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Kazemeini, A ; Sharif Univercity of Technology

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Type of Document: Article
DOI: 10.1134/S1070428006010088
Abstract:
Treatment of aliphatic and aromatic aldehydes with chiral amines and trimethylsilyl cyanide in the absence or in the presence of Lewis acids (including lithium perchlorate) under solvent-free conditions afforded the corresponding α-aminonitriles in good yields and with a diastereoselectivity of 68 to 86%
Keywords:
Source: Russian Journal of Organic Chemistry ; January 2006, Volume 42, Issue 1, pp 48-51
URL: http://link.springer.com/article/10.1134%2FS1070428006010088