Effect of Size and Surface Conditions of Titanium Dioxide Nanoparticles on Sonodynamic Therapy Process

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Soleimani, Foad | 2013

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 45817 (07)
University: Sharif University of Technology
Department: Materials Science and Engineering
Advisor(s): Madaah Hosseini, Hamid Reza
Abstract:
In the present study, a simple synthesis route was used to obtain Titanium dioxide nanoparticles with aggregates different in size. The purpose was to study the effect of TiO2 nanoparticles size on photocatalytic activity and develop it to sonocatalytic properties. Surface modification with polymeric and/or anionic agents were carried out to stabilize titania nanoparticles in aqueous media with neutral pH, specifically in SBF. Sonocatalytic properties of modified and bare particles were compared to show if the particles may be used in future studies on sonodynamic therapy. Results showed that increment in size of the aggregates, similar to primary particles, lead to lower properties due to reduction in effective surface and also involving phenomena such as Ostwald Ripening and epitaxial assembly. Surface modification by PVA enhanced sonocatalytic activity as the result of its suppression effect on particle growth induced by ultrasonic process whilst anionic modifiers decrease the properties dramatically; probably because of antioxidant nature and blocking effect on ultrasound waves
Keywords:
Colloidal Stability ; Biocompatibility ; Poly Vinyl Alcohol ; Sonocatalytic Properties ; Sodium Polyacrylate