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Preparation and Investigation of the Electrochemical behavior of the Glassy Carbon Electrode Modified with Nanodiamond/Nanographite and NanoNi Composites: Applications to Pharmaceutical Determinations

Koolivand, Zeinab | 2013

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 45889 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Shahrokhian, Saeed
  7. Abstract:
  8. Part 1: In the first work, the electrochemical behavior of Ceftriaxone was thoroughly investigated at the surface of a glassy carbon electrode modified with nano-diamond graphite (NDG). The surface morphology and electrochemical properties of thin film modifier are characterized by Scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. The prepared electrode showed a considerable improvement in the peak current of Ceftriaxone compared to either glassy carbon electrode or nanodiamond (NDs) modified glassy carbon electrode. Under the optimum conditions, the modified electrode showed a wide linear dynamic range of 0.04-10 μM with the detection limit of 10 nM for voltammetric determination of Ceftriaxone. The modified electrode was successfully applied for the accurate determination of trace amounts of Cefriaxone in pharmaceutical and clinical preparations. Part 2: In the second work, Ni nanoparticles are fabricated on a Nano-diamond Graphite (NDG) coated glassy carbon electrode (GCE) by the electrodepoition method. The surface morphology of the film (Ni/NDG) deposited on glassy carbon electrode is characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques. The modified electrode is used as a new and sensitive electrochemical sensor for the voltammetric determination of Cefepime. The results of voltammetric studies exhibited a considerable improvement in the oxidation peak current of Cefepime compared to glassy carbon electrodes individually coated with NDG. Under the optimized conditions, the modified electrode showed a wide linear dynamic range of 0.06-10 μM with detection limit of 15 nM for the voltammetric determination of Cefepime
  9. Keywords:
  10. Nano Diamond/Graphite ; Nickel Nanoparticle ; Modified Electrodes ; Cyclic Voltammetry ; Ceftriaxone

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