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Synthesis of Pyrimidine Derivatives Fused to Pyrazol Ring Using Iodine-Catalyzed Two Component Reaction & Synthesis and Application of Magnetic Nickel Ferrite Nanoparticles in the C-N Bond Formation

Moafi, Atiyeh | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46214 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Matloubi Moghadam, Firouz
  7. Abstract:
  8. The fused pyrimidine rings have many biological applications such as antibacterial, antiviral, antitumor and anti-inflammation activity. Therefore, their synthesis has attracted many attentions. In this thesis, the synthesis of fused pyrazolopyrimidine rings through two component reaction catalyzed by iodine was investigated. In this reaction, iodine is used to active the imine bond. Low toxicity, availability, low cost and stability to air are some benefits of iodine as a Lewis acid leading to widespread application of I2 in many different organic transformation. Mild reaction conditions, high yields and lower reaction times are among the main advantage of these reactions.
    Another part of this thesis was the application of nickel ferrite nanoparticles as catalyst in the C-N coupling reaction. Nickel ferrite nanoparticles are cheap, available, recoverable and reusable and their synthesis is also convenient. On the other hand, amines are the main building blocks of many pharmaceuticals, pesticides, herbicides, dies and natural products. So their synthesis has been studied widely in the recent years. Through many different ways employed for the formation of these compounds, metal catalyzed coupling reactions has attracted many attentions due to their high yields, mild reaction conditions and availability of the starting materials. This reaction has many advantages such as very high to excellent yields and mild and green reaction conditions. Furthermore, this reaction can be used for a vast range of aryl halides and different types of amines.
  9. Keywords:
  10. Two Component Raction ; Arylhalide ; Pyrimidines ; Amines ; Iodine ; Imines ; Coupling ; Pyrazole ; Coupling Reactions

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