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Influence of Geometrical Parameters on Hemodynamics of Blood Flow in Coronary Artery Bypass Graft by FSI Numerical Method

Saffari, Ali | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 46663 (07)
  4. University: Sharif University Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Halali, Mohammad; Hossein Ahmadi, Zargham
  7. Abstract:
  8. In this study, the simulation of blood flow through a stenosed coronary artery and a bypass graft are discussed using fluid-structure interaction numerical method. Effects of the geometrical parameters of CABG surgery on hemodynamics have been studied. Investigated hemodynamic variables include shear stress on the vessel wall, the velocity profile in high-risk areas and the pathlines. Lower than 0.5 Pa shear stress on intimal layer of arteries causes the formation of plaque on the wall. Angle of 30 degrees and diameter ratio of bypass to host artery of 1:1 are proposed as the optimum geometry. The distance of the anastomosis from the site of occlusion has no effect on surgery. Also, considering the time period of 0.8 seconds as heart rate, the worst condition for hemodynamics parameters has been presented in 0.5 seconds after the P wave on the electrocardiogram and simulation results have been reviewed at this time. It has been shown that severity stenosis of host artery increases over time even after surgery. This leads to inevitable restenosis of bypass graft and coronary artery downstream from the anastomosis. Increase of blood viscosity improves hemodynamic conditions of blood flow slightly. Solving problem by taking blood as Non-Newtonian fluid causes 7.7% changes in simulation results. The best anastomosis location is on curve zones with small radius
  9. Keywords:
  10. Secondary Flow ; Non-Newtonian Fluids ; Fluid-Structure Interaction ; Restenosis ; Optimum Angle ; Elastic Wall

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