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Design and Simulation of a Microfluidic Blood Cells Counting Device

Yavari, Meysam | 2014

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  1. Type of Document: M.Sc. Thesis
  2. Language: English
  3. Document No: 47041 (58)
  4. University: Sharif University of Technology, International Campus, Kish Island
  5. Department: Science and Engineering
  6. Advisor(s): Saeedi, Mohammad Saeed; Sani, Mehdi
  7. Abstract:
  8. A Lab-On-a-Chip (LOC) is a device which can integrate one or many laboratory functions on a small chip with millimeters to few square centimeters in size. LOC is a subset of MEMS devices and known as “Micro Total Analysis Systems” (µTAS) as well. LOC technology is closely related to microfluidics which primarily describes the physics, manipulation and study of minute amount of fluids.In this research we tried to simulate the performance of a microfluidic device for counting blood cells to find main factors of it for design and manufacturing. This research has two main sections, hydrodynamics of fluid inside the microchannels and finding electrical performance of designed Coulter counter for particles like RBCs and WBCs. FLUENT® commercial code has been used for simulation of flow inside the microchannels and COMSOL® code for finding the electrical performance of designed Coulter Counter. External flow control system coupled with hydrophobic passive valves inside the chip is used to control the fluid flow and adds the ability of easy sample metering in the system. Using idea of study on the shape and value of impedance pulses produced by Coulter counter is the main innovation in this study which is able to find the size distribution of particles in the solution besides counting them
  9. Keywords:
  10. Simulation ; Electrical Impedance ; Fluent Software ; Microfluidic Devices ; Blood Cells Counting ; COMSOL Software

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