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Preparation and Characterization of Polyurethane/Carbon Nanoparticles Nanocomposite for Biomedical Applications (Orthopedic)

Alishiri, Maryam | 2015

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 47319 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Shojaei, Akbar; Abd Khodaei, Mohammad Jafar
  7. Abstract:
  8. Present study demonstrated carbon nanoparticles/acrylate-terminated polyurethane composites as promising materials for bone implants applications. Neat polymer and composites containing nanoparticles at different loadings up to 2 wt % were prepared by in situ polymerization method. Morphological analysis exhibited that nanoparticles caused considerable phase separation between soft and hard domains as well as increased crystallinity. Mechanical analysis showed a significant improvement in mechanical properties. Maximum improvement in tensile properties of APUA was observed at 1 wt% loading of ND-HEAMs, namely 175% improvement in modulus. In vitro biocompatibility evaluation via culturing human osteosarcoma cells (MG-63 osteoblast-like cell line), demonstrated no adverse effect on cell viability of samples. Furthermore, composites showed favorable cell adhesion and growth, and nanoparticles did not cause any negative effect on proliferation. SEM microphotographs of cells grown on samples suggested that the proliferation of cells could maintain their normal morphology while adhered on the surface of films. Hydrophilic nature of ND-HEMAs enhanced biocompatibility of composites. The present investigation showed that ND-HEMA and CNT-HEMA can be promising nanoparticles which is able to enhance the mechanical properties without destructive role on the biocompatibility of APUA. This makes the composites favorable biomaterial for hard tissue engineering where the enhanced mechanical properties are required
  9. Keywords:
  10. Nanocomposite ; Biocompatibility ; Bone Implant ; Carbon Nanotubes ; Nanodiamond ; Polyurethane ; Bone Implant

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