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Thermo- and pH-sensitive dendrosomes as bi-phase drug delivery systems

Adeli, M ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1016/j.nano.2013.05.013
  3. Publisher: 2013
  4. Abstract:
  5. Fully supramolecular dendrosomes (FSD) as bi-phase drug delivery systems are reported in this work. For preparation of FSD, amphiphilic linear-dendritic supramolecular systems (ALDSS) have been synthesized by host-guest interactions between hyperbranched polyglycerol having β-cyclodextrin core and bi-chain polycaprolactone (BPCL) with a fluorescine focal point. Self-assembly of ALDSS in aqueous solutions led to FSD. They were able to encapsulate paclitaxel with a high loading capacity. The dendrosome-based drug delivery systems were highly sensitive to pH and temperature. They were stable at 20-37. °C and pH7-8, but dissociated and released drug at temperatures lower than 20. °C or higher than 37. °C and pH lower than 7 quickly. Dissociation of FSD building blocks by temperature or pH resulted in inclusion complexes between the released drugs and polyglycerol as the secondary drug delivery system. From the Clinical Editor: This paper reports on the development of a pH- (below 7) and temperature- (below 20. °C or above 37. °C) sensitive delivery system using supramolecular dendrosomes for more specific delivery and release of drugs using paclitaxel as a model
  6. Keywords:
  7. Biphase-drug delivery systems ; Controlled release ; Supramolecules ; Delivery systems ; Drug delivery ; Drug interactions ; Supramolecular chemistry ; Loading ; paclitaxel ; Polycaprolactone ; Amphiphilic linear dendritic supramolecular system ; Aqueous solution ; Drug delivery system ; Drug release ; Fully supramolecular dendrosome ; Heat sensitivity ; pH ; AFM ; ALDSS ; Amphiphilic linear-dendritic supramolecular systems ; Atomic force microscopy ; beta-cyclodextrin ; BPCL ; CAC ; critical aggregation concentration ; DLC ; DLE ; DLS ; Drug loading content ; drug loading efficiency ; Dynamic light scattering ; FSD ; Fully supramolecular dendrosomes ; Gel permeation chromatography ; GPC ; hyperbranched polyglycerol with a cyclodextrin core ; Infrared ; IR ; Linear-dendritic copolymers ; Lipid-like bi-chain polycaprolactone ; Mn ; Molecular weight ; NMR ; Nuclear magnetic resonance ; PG ; Polyglycerol ; PTX ; TEM ; Transmission electron microscopy ; Ultraviolet ; UV ; β-CD ; β-CD-g-PG ; Antineoplastic Agents, Phytogenic ; beta-Cyclodextrins ; Delayed-Action Preparations ; Drug Delivery Systems ; Glycerol ; Hydrogen-Ion Concentration ; Models, Molecular ; Polymers ; Temperature
  8. Source: Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 9, Issue 8 , 2013 , Pages 1203-1213 ; 15499634 (ISSN)
  9. URL: http://www.nanomedjournal.com/article/S1549-9634%2813%2900264-5/abstract