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Boric acid/glycerol as an efficient catalyst for synthesis of thiomorpholine 1,1-dioxide by double michael addition reaction in water

Halimehjnai, A. Z ; Sharif University of Technology | 2013

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  1. Type of Document: Article
  2. DOI: 10.1080/00397911.2011.594930
  3. Publisher: 2013
  4. Abstract:
  5. Thiomorpholine 1,1-dioxides were prepared with double Michael addition reaction of aromatic amines to divinyl sulfone catalyzed by boric acid/glycerol in water. This catalyst system was also used for the Michael addition reaction of aromatic amines to electron-deficient alkenes. The reaction is simple and green and gives good to excellent yields
  6. Keywords:
  7. Aromatic amines ; Michael addition ; water ; 1,3 (dithiomorpholine 1,1 dioxide) benzene ; 1,4 (dithiomorpholine 1,1 dioxide) benzene ; Alkene ; Aromatic amine ; Boric acid ; Divinyl sulfone ; Glycerol ; N (3 methoxyphenyl) thiomorpholine 1,1 dioxide ; N (4 bromophenyl) hiomorpholine 1,1 dioxide ; N (4 chlorophenyl) thiomorpholine 1,1 dioxide ; n (4 methylphenyl) thiomorpholine 1,1 dioxide ; Oxide ; Thiomorpholine 1,1 dioxide ; Unclassified drug ; Catalyst ; Chemical structure ; Double Michael addition ; Synthesis
  8. Source: Synthetic Communications ; Volume 43, Issue 2 , 2013 , Pages 191-197 ; 00397911 (ISSN)
  9. URL: http://www.tandfonline.com/doi/abs/10.1080/00397911.2011.594930