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A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption

Barzegar Jalali, M ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. Publisher: 2012
  3. Abstract:
  4. Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature. Results. The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the suitability of the approach. A theoretical justification was provided for the model considering the unified classical release laws. Conclusion. The model does not necessitate bolus intravenous drug data and seems to be suitable for IVIVC of drugs with release rate-limited absorption
  5. Keywords:
  6. Carbazole derivative ; Celecoxib ; Danazol ; Docetaxel ; Estradiol ; Fluorouracil ; Flurbiprofen ; Heparin ; Insulin ; Methotrexate ; Mifepristone ; Nifedipine ; Nitrendipine ; Vinpocetine ; Nanoparticle ; Rhodamine ; Tobramycin ; Analytical error ; Area under the curve ; Drug delivery system ; Drug formulation ; Drug release ; In vivo study ; Prediction ; Theoretical model ; Biological model ; Chemistry ; Methodology ; Bioavailability ; Correlation analysis ; Dissolution ; Drug absorption ; Mathematical analysis ; Mathematical model ; Molecular weight ; Wettability ; Absorption ; Area Under Curve ; Chemistry, Pharmaceutical ; Drug Delivery Systems ; Models, Biological ; Nanoparticles ; Nanotechnology ; Pharmacokinetics
  7. Source: Journal of Pharmacy and Pharmaceutical Sciences ; Volume 15, Issue 4 , 2012 , Pages 583-591 ; 14821826 (ISSN)
  8. URL: http://www.ncbi.nlm.nih.gov/pubmed/23106960