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Observer-Based Output Feedback Linearization Control with Application to HIV Dynamics

Hajizadeh, I ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1021/ie5022442
  3. Publisher: American Chemical Society , 2015
  4. Abstract:
  5. This paper presents the feedback linearization control of HIV infection. A multi-input multi-output (MIMO) dynamic nonlinear HIV infection model for this purpose has been used. For this purpose, three widely used drugs are considered. A Luenberger-like nonlinear observer (LNO) is designed for estimation of unavailable states. To minimize the side effects of drugs, the concentration of ZDV which has the highest side effect is fixed to a minimum value and the external controllers parameters are obtained by maximizing an objective function. In the control design, limitations on drug consumption and unavailability of all states are taken into account. The closed-loop stability has been established in the presence of the observer dynamics and input limitations. Robustness of the proposed treatment strategy against model parameter uncertainties, noise, or sparse measurements has been demonstrated through simulation study. Finally, by including pharmacological models, an impulsive control strategy for HIV treatment has been considered
  6. Keywords:
  7. Drug interactions ; Feedback control ; Linearization ; MIMO systems ; Spatial variables control ; Uncertainty analysis ; Closed loop stability ; External controller ; Feedback linearization control ; Impulsive control strategy ; Multi input multi output ; Non-linear observer ; Objective functions ; Observer based output feedbacks ; Feedback linearization
  8. Source: Industrial and Engineering Chemistry Research ; Volume 54, Issue 10 , January , 2015 , Pages 2697-2708 ; 08885885 (ISSN)
  9. URL: http://pubs.acs.org/doi/abs/10.1021/ie5022442