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Developmental model of an automatic production of the human bronchial tree based on L-system

Davoodi, A ; Sharif University of Technology | 2016

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  1. Type of Document: Article
  2. DOI: 10.1016/j.cmpb.2016.04.021
  3. Publisher: Elsevier Ireland Ltd , 2016
  4. Abstract:
  5. Background and objective: The human lungs exchange air with the external environment via the conducting airways. The application of an anatomically accurate model of the conducting airways can be helpful for simulating gas exchange and fluid distribution throughout the bronchial tree in the lung. Methods: In the current study, Lindenmayer system (L-system) has been formulated to generate the bronchial tree structure in a human lung. It has been considered that the structure of the bronchial tree is divided into two main segments: 1) The central airways (from the trachea to segmental bronchi) and 2) the dichotomous structure (from segmental bronchi to terminal bronchioles). Two sets of parametric rewriting rules which can be used to develop central and peripheral airways have been proposed; the first set used to develop central airways consists of seven rules, while the second rule set contains four rules. Results: The proposed model is capable of generating bronchial tree inside the volume of the host lung; and comparison of the resulting model with those reported in the literature shows that the morphometric characteristics of L-system structure are in good agreement with their corresponding experimental data. Conclusion: The resulting model can be used to obtain a mathematical model required for the study of transport phenomena occurring in the lung during respiration. © 2016 Elsevier Ireland Ltd
  6. Keywords:
  7. Bronchial tree ; L-system ; Lung ; Rewriting rule ; Biological organs ; Respiratory system ; Dichotomous structure ; External environments ; Human bronchial tree ; L-systems ; Morphometric characteristics ; Rewriting rules ; Trees (mathematics) ; Breathing ; Bronchiole ; Experimental model ; Human ; Segmental bronchus ; Statistical model ; Tracheobronchial tree ; Anatomic model ; Anatomy and histology ; Bronchus ; Automation ; Bronchi ; Humans ; Models, Anatomic
  8. Source: Computer Methods and Programs in Biomedicine ; Volume 132 , 2016 , Pages 1-10 ; 01692607 (ISSN)
  9. URL: http://www.sciencedirect.com/science/article/pii/S016926071530016X