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Optimal Control of Electrochemical Treatment of Tumors

Hosseini, Soroush | 2017

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 49802 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Pishvaie, Mahmoud Reza
  7. Abstract:
  8. In this project, we have assessed the electrochemical treatment method. In this method, pH decrease of the place where a tumor is located engenders the necrosis of cancer cells and consequently they are destroyed. The process of pH decrease is caused by exerting voltage on electrods that are located near the tumor. The aims of optimizing this methods are to minimize the pH that results in the increase of cancer cell annihilation and to minimize the HClO and Cl2 products which are toxic and chage the healthy tissues to cancer cells. In this project, the model of electrochemical treatment method is explained, and then this model is simulated using the parametes which are provided in the litersture. Then this method is optimized using the nelder-mead algorithm. The processes of simulation and and optimization of this method are accomplished using COMSOL. In the process of optimization of this method, the cathode voltage is used as the controlling variable which should optimize a cost function. The cost function must minimize the production of cl- which causes the two mentioned toxic products and maximize the production of H+ to decrease the pH. Thus the cost function is the proportion of Cl- to H+ that this cost function must be minimized. Innovation of this research is optimization of the applied voltage to the cathode which despite its importance, this issue has not been addressed in past researches. The result obtained from this study was achieving optimal function of the applied voltage to the cathode electrode which by applying it to the average electrode in tumor issue, the concentration of H+ increases significantly. Moreover, despite a significant increase in H+, Cl- concentration did not change substantially. But due to decrease of pH in tumor tissue, Cl- impact is reduced. Therefore, according to these two issues, it can be concluded that by doing this optimization, the tissue destruction has increased significantly
  9. Keywords:
  10. Electrochemical Treatment ; Tumors ; COMSOL Software ; Simulation ; Dynamic Optimization ; Cancer Treatment

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