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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 50253 (08)
- University: Sharif University of Technology
- Department: Mechanical Engineering
- Advisor(s): Dehghani Firoozabadi, Bahar
- Abstract:
- The tumor is a collection of cells (cell mass) caused by the lack or ineffectiveness of cellular proliferation inhibitors. Many types of cancers are associated with the emergence of a tumor, a tissue with specific physiological characteristics. The tumors grow very fast so researchers try to prevent their growth and eventually destroy them. Thermal ablation by MWA(microwave ablation) is a common and minimally-invasive treatment for primary and secondary liver tumors that can not be cured by surgery. During treatment, the tissue is heated by microwaves and at a temperature higher than 50 degree Celsius, destroyed by thermal ablation. In this study, two thermal models have been used to simulate the MWA process. Due to the nature of the veins of liver and the physical limitations of the existing electrodes, the radius of thermal ablation is limited. Liposomes containing anticancer drugs DOX (LTSL) at temperatures above the 39 degree Celsius Quickly release their content. Therefore, in the present study, the therapeutic approach MWA is integrated with a multi-compartmental modeling drug delivery and the effect of temperature distribution and blood perfusion changes on the distribution of the drug has been investigated. Finally, in the present simulation, it has been shown that the concentration of the drug in the target site can be increased and the toxicity of the drug can be reduced
- Keywords:
- Thermal Ablation ; Hyperthermia ; Simulation ; Drug Delivery ; Liposoms ; Compartment Model ; Pharmacokinetic ; Microwave Ablation (MWA) ; Drug Concentration
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