Loading...

Thermodynamic and kinetic stabilities of G-quadruplexes in apolar solvents

Fadaei, E ; Sharif University of Technology | 2017

55 Viewed
  1. Type of Document: Article
  2. DOI: 10.1021/acs.orglett.6b03606
  3. Publisher: American Chemical Society , 2017
  4. Abstract:
  5. In contrast to more polar media, G-quadruplex assembly reveals remarkably high thermodynamic and kinetic stability in toluene solutions. Depending on the substituents installed at the lipophilic guanosine, either a dodecamer or an octamer complex is formed in the presence of K+ or Na+ salts that resist conditions of high dilution and elevated temperatures without exhibiting significant dissociation. Moreover, kinetic exchange between complexed and uncomplexed G is slow enough in NMR to monitor G-quadruplex formation along a day time scale. © 2017 American Chemical Society
  6. Keywords:
  8. Source: Organic Letters ; Volume 19, Issue 3 , 2017 , Pages 460-463 ; 15237060 (ISSN)
  9. URL: https://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03606