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Preparation and Characterization of Hydroxyapatite/Polycaprolactone Nanocomposites by Sol-gel Process

Rezaei, Amirreza | 2011

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 42811 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Mohammadi, Mohammad Reza
  7. Abstract:
  8. Hydroxyapatite (HA) is the most substantial mineral constituent of a bone which displays splendid biocompatibility and bioactivity properties. Nevertheless, its mechanical property is not utmost appropriate for a bone substitution. Therefore, a composite consist of HA and a biodegradable polymer is usually prepared to generate an apt bone scaffold. In the present work polycaprolactone (PCL), a newly remarkable biocompatible and biodegradable polymer, was employed as a matrix and hydroxyapatite nanoparticles and nanorods were used as a reinforcement element of the composite. HA/PCL nanocomposites were synthesized by three new in-situ sol-gel processes using a diverse range of phosphorus and calcium precursors and alcoholic or aqueous solvents. Chemical, physical and biological characteristics of the composites were studied by different analyses such as FE-SEM, XRD and FTIR. The results revealed that the nanocomposites included a homogenous dispersion of nanoparticles or nanorods of HA or slightly carbonated HA (depending on the synthesis method) in PCL matrix. Furthermore, biological properties of nanocomposites were investigated under in vitro condition. For this purpose, HA/PCL scaffolds were prepared through a solvent casting/particulate leaching process. The absorption of osteoblast cellules and their biocompatibility characteristics were studied in a saturated simulated body fluid (5×SBF) for 3 and 7 days.. The results indicated that the scaffolds meet the requirements of materials for bone tissue engineering and could be used for many clinical applications in orthopedic and maxillofacial surgery. Furhermore, it was observed that nano HA has more bioactivity in comparison to conventional HA. In addition, HA nanorods showed higher bioavive property than HA nanoparticles due to the formation of HA layer after immersion into 5×SBF solutions
  9. Keywords:
  10. Sol-Gel Method ; Hydroxyapatite ; Nanostructured Composite ; Polycaprolactone Composite ; Biocompatible Polymer ; Nanocomposite Scaffold

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