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    Hydroxyapaptite Coating on Zirconia Toughened Alumina Nanocomposite by Biomimetic Method

    , M.Sc. Thesis Sharif University of Technology Esfahani, Hamid (Author) ; Nemati, Ali (Supervisor) ; Salahi, Esmaeil (Co-Advisor)
    Abstract
    Zirconia toughened alumina (ZTA) Nanocomposites were prepared using nano sized Zirconia (ZrO2) powders doped with 3% mol of yttria (Y2O3) nanopowders and the sintering behavior at different temperature (1450 °C, 1550 °C and 1650 °C) were studied. The ZTA composite with different amount of partially stabilized Zirconia (PSZ)(5, 10, 15 and 20% mol) were prepared via axial pressing and then sintered to achieve maximum densification. After that phase changes of the samples were monitored. SEM was used for microstructural study and hardness and fracture toughness were determined by means of Vickers indentation. X-ray diffraction pattern showed that at constant composition, tetragonal zirconia... 

    Hydroxyapatite Coating on Nanotubes TiO2

    , M.Sc. Thesis Sharif University of Technology Goodarzi, Mena (Author) ; Afshar, Abdollah (Supervisor) ; Dolati, Abolghasem (Supervisor)
    Abstract
    There are many techniques that have been used to create hydroxyapatite nanoparticles coating on nanotubes. Electrophoretic deposition (EPD) is one of the methods that has advantages of short formation time, needs simple apparatus, little restriction of the shape of substrate, no requirement for binder burnout as the green coating contains few or no organics. In the research, first, titanium dioxide nanotubes were fabricated by anodic oxidation. Anodizing voltage effect on the morphology of nanotubes was evaluated. SEM images was shown that in the anodizing voltage 20V, nanotubes were the most regular. Then, Hydroxyapatite nanoparticles has been deposited onto nanotublar TiO2 by... 

    Sintering Improvement of Nano Hydroxyapatite Bodies by Magnesium Incorporation and Using Microwave Sintering

    , M.Sc. Thesis Sharif University of Technology Ghods, Amin (Author) ; Sadrnejhad, Khatiboleslam (Supervisor) ; Behnam Ghader, Ali Asghar (Supervisor)
    Abstract
    Magnesium is one of most important elements in bio hedroxyapatite. Magnesium effects on all stages of bone growth metabolism. Also increases bone’s osteoblastic and osteoclastic activities. That’s why incorporation of Mg ions into hudroxyapatite structure has become one of interesting fields for bone implants production. In addition Mg can improve sintering and mechanical properties of HAp. Thet’s why in this investigation the effect of incorporated Mg into HAp structure has been studied. Three kinds of powders have been prepared to perform this study. Pure HAp nano powder produced via sol-gel method, Mg contain HAp nano powder produced via sol-gel method and a mixture of nano HAp and nano... 

    Synthesis and Characterization of Nano-Composite Based on Supramolecuylar Poly Caprolactone/ Hydroxyapatite for Tissue Engineering Application

    , M.Sc. Thesis Sharif University of Technology Mehmanchi, Mohammad (Author) ; Bagheri, Reza (Supervisor) ; Shokrollahi, Parvin (Supervisor) ; Ataei, Mohammad (Co-Advisor)
    Abstract
    Synthetic polymers have a high capacity to provide and manufacture the pieces used in tissue engineering. However, optimizing the biocompatibility, bioresorbableility and mechanical properties simultaneous with processability of material is complicated and requires a lot of effort at designing different parts of the system. On the other hand, due to existence of secondary bonds (such as metal-ligand coordination or hydrogen bond) supramolecular polymers are able to respond to some stimuli such as temperature, pH, or pressure, which is important in terms of dynamic nature of interaction between the living cells and the external matrix of cell. Recently there have been extensive studies on... 

    “ Nano Oxide Layer Forming on the Surface of Porous Nitinol Shape Memory Alloy for Improving Surface Properties “

    , M.Sc. Thesis Sharif University of Technology Fattahzadeh, Mehrdad (Author) ; Sadrnejhad, Khatiboleslam (Supervisor)
    Abstract
    In this project ,it has been done different surface treatment on 6 samples of nitinol with 40 % prosity,three of them are anodized by H2SO4 ,Hf, Acetic acid, one of them is treated with plasma spray with TIO2 powder, one of them is putted in the furnace at 700 degrees for an hour, and the last one is bare ; Moreover, these treated samples are putted in Simulated body fluid for 16 days . After this period of time, we analyzed the results. Then the cell adhesion amount of osteo blast cells (MG 63) is measured to these samples by immersing them for 3 days in these cells.The results are investigated by SEM ,XRD(X pertpro produced by Panalitical), XRF(530-XRF-01), AAS( AA240), Roughness measuring... 

    Electrophoretic Deposition of Chitosan- Hydroxyapatite- Multiwalled Carbon Nanotube Composite Coatings

    , M.Sc. Thesis Sharif University of Technology Batmanghelich, Farhad (Author) ; Ghorbani, Mohammad (Supervisor)
    Abstract
    At the first stage, chitosan-hydroxyapatite-multiwalled carbon nanotube (CH-HA-MWCNT) composite coatings were synthesized by electrophoretic deposition technique (EPD) on Ti6Al4V and 316L stainless steel substrates at different levels of pH and characterized by X-ray diffraction (XRD), Raman spectroscopy, FTIR and field emission scanning electron microscopy (FESEM). A smooth distribution of HA and MWCNT particles in a chitosan matrix with strong interfacial bonding was obtained. At the second stage, effect of pH and MWCNT content of the suspension on corrosion behavior and mechanism of deposition were studied. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS)... 

    The Investigation on Hydroxyapatite Coating on Magnesium Alloy and Its Properties

    , M.Sc. Thesis Sharif University of Technology Mazaheri Kalahrood, Amir (Author) ; Afshar, Abdollah (Supervisor)
    Abstract
    Magnesium and its alloys are biodegradable materials with mechanical properties similar to the bone tissue, therefore these materials are suitable for producing orthopedic implants. Unfortunately Magnesium and its alloys are corroded too fast in physiological environment which is the main obstacle for usage of these materials as orthopedic implants. Producing Hydroxyapatite(HA) coatings on surface of Magnesium and its alloys is one of the popular and useful methods for reducing the corrosion rate in physiological environment. HA is a biocompatible and bioactive coating with the ability to bond chemically with the bone tissue and therefore it is largely used as a bioactive coating on the... 

    Synthesis and Characterization of Nano Hydroxyapatite/Acrylated Polyurethane Nanocomposites

    , M.Sc. Thesis Sharif University of Technology Aboutalebi Anaraki, Nadia (Author) ; Shojaei, Akbar (Supervisor) ; Abdekhodai, Mohammad Jafar (Supervisor)
    Abstract
    In the present study, the acrylated polyurethane/nanohydroxyapatite (APU/n-HAp) nanocomposites were fabricated for use in bone tissue regeneration. The APU was synthesized based on poly(ε-caprolactone) diol (PCL), aliphatic 1,6- hexamethylene diisocyanate (HDI) and hydroxyethyl methyl acrylate (HEMA). The effect of HAp nanoparticles on the physicochemical properties of APU was evaluated. The APU/n-HAp nanocomposites were characterized using X-ray diffraction (XRD), dynamic mechanical thermal analyses (DMTA), scanning electron microscopy (SEM) and mechanical tests including tensile strength and elongation at break. The increase in physical properties achieved by incorporation of n-HAp... 

    Effect of Mullite Content on HAp-Mullite Composite for Hard Tissue Application

    , M.Sc. Thesis Sharif University of Technology Rahmani, Marzieh (Author) ; Faghihi Sani, Mohammad Ali (Supervisor) ; Solati Hashjin, Mehran (Supervisor)
    Abstract
    In this study effect of various mullite contents, as reinforcement phase, on phase combination, fracture surface and mechanical propertiese of hydroxyapatite- mullite composite has been investigated.
    The used hydroxyapatite powder was synthesized through acid- base route and further calcination. XRD results demonstrated partially decomposition of HA in to β- TCP and CaO during the calcination. SEM image of the prepared HA powder showed that they were spherical and agglomarated.
    The mixed HA with various amounts of the ball- milled mullite (10- 40 wt%)were pressed and sintered at 1350°C for 2h. Dominant phase in all composite samplese after sintering was Ca9Al(PO4)7.
    Phase... 

    Preparation and Characterization of HA/ZrO2 Biocomposite Coating on 316 Stainless Steel Fabricated by Electrodeposition

    , M.Sc. Thesis Sharif University of Technology Shojaee, Peyman (Author) ; Afshar, Abdollah (Supervisor)
    Abstract
    In this research, role of zirconia nanoparticles as a biocompatible material which has great mechanical properties, was investigated on corrosion behavior and bonding strength of HA coating. HA- ZrO2 composite prepared by a 2-step pulse electrodeposition method. Effect of pH (3.5, 4.5), bath temperature (60, 80 ͦC), current density (0.5, 1, 2 mA/cm2) and zirconia concentration (5, 10, 15 g/L) on coating characteristics were studied. X-ray diffraction was employed for phase analysis. Morphology and microstructure of samples observed utilizing scanning electron microscope (SEM) and elemental analysis was done by EDS. In order to corrosion studies electrochemical impedance spectroscopy (EIS)... 

    In Situ Synthesis of Nanorod Hydroxyapatite Reinforced Polycaprolactone Nanocomposite for Bone Tissue Engineering Application

    , M.Sc. Thesis Sharif University of Technology Moeini, Saeed (Author) ; Mohammadi, Mohammad Reza (Supervisor) ; Simchi, Abdol Reza (Supervisor)
    Abstract
    Hydroxyapatite is the most substantial inorganic constituent of bone tissue which displays splendid biocompability and bioactivity. Nevertheless, its mechanical properties is not utmost appropriate for a bone substitutes. Therefore, it is used to improve the mechanical properties of polymer matrix composite scaffolds. In the present work polycaprolactone as a polymeric matrix was employed to fabricate hydroxyapatite-polycaprolactone biocomposite scaffolds via in situ route. Solvothermal method was employed to synthesize in situ hydroxyapatite in polymer matrix. Porous scaffolds were fabricated via freeze-drying/porogen leaching. Physical, mechanical (compressive module and compressive... 

    Loading of Drug and Nanostructured Coating on Dental Implant

    , M.Sc. Thesis Sharif University of Technology Abbaspour Ghomi, Somayya (Author) ; Sadrnezhaad, Khatiboleslam (Supervisor)
    Abstract
    The aim of this project is to load analgesic drug; Paracetamol on dental implant. The implant is titanium alloy (Ti-6Al-4V). There are two kinds of samples of anodized and HA coated onto anodized. They are in the shape of the sheets in this study. The electrodeposition and anodization carried out in order to treat the two samples. Nanotubes were formed during anodic oxidation of the samples in the 1M Ammonium sulfate (NH₄)₂SO4 and 5wt% Ammonium fluoride NH4F electrolyte. They are expected to play role of carrier for the model drug; paracetamol. The results showed that HA anodized Ti-6-4 has the ability to hold higher amounts of drug and also can keep the drug for a longer time than the... 

    Design and Manufacture of Nanostructured Hydroxyapatite coated Foamy core@compact Shell Ti-6Al-4V Nanocomposite

    , M.Sc. Thesis Sharif University of Technology Ahmadi Seyedkhani, Shahab (Author) ; Sadrnezhad, Khatiboleslam (Supervisor)
    Abstract
    The main purpose of this research is design and manufacture of nanostructured hydroxyapatite-coated foamy core@compact shell Ti-6Al-4V bone-like composites for utilization as substitutive implant for cortical bone having porous core. The production procedure consist of two steps; (a) fabrication of foamy core@compact shell Ti-6Al-4V alloy using powder metallurgy-space holder technique, (b) precipitation of hydroxyapatite on the Ti-6Al-4V alloy specimens via pulse electrodeposition process. The bone-like structures were designed to reduce the stress shielding which ensures long-term stabilization of implants. It is while that, the hydroxyapatite coating improve the biological response of... 

    Chitosan/Gelatin/Mg Substituted Hydroxyapatite Nano Composite Scaffold for Bone Tissue Engineering

    , M.Sc. Thesis Sharif University of Technology Azamian, Fariba (Author) ; Mohammadi, Mohammad Reza (Supervisor) ; Fathi, Mohammad Hossein (Co-Advisor)
    Abstract
    The present study is work on fabrication and characterization of a chitosan/ gelatin/ Mg substituted hydroxyapatite nano composite scaffold for bone tissue engineering. At the first step pure and Mg-substituted hydroxyapatite (HA) (Ca10-xMgx(PO4) 6OH2) nano-hexagonal rods with 14–45 nmdiameter.for this, calcium nitrate, magnesium phosphate hydrate and potassium dihydrogenphosphate were used as precursors for Ca, Mg, and P, respectively. Calculated amounts of magnesium ions (Mg+2) especially from 0 to 8% (molar ratio) were incorporated as substituted into the calcium sol solution. Deionized water was used as a diluting media for HA sol preparation and ammonia was used to adjust the pH= 9.... 

    Synthesis of Hydroxyapatite Whisker and Nanorods/Polycaprolactone Composites and Scaffolds: In vitro & In vivo studies

    , M.Sc. Thesis Sharif University of Technology Lebasi, Mohammad Ali (Author) ; Mohammadi, Mohammad Reza (Supervisor)
    Abstract
    This work describes the effect of hydroxyapatite with different morphology including nanorods and whisker on the properties of hydroxyapatite/polycaprolactone (HA/PCL) composite. Biodegradable polymer/Hydroxyapatite (HA) composites with the morphology of nanorods and whisker of (HA) as bone replacement scaffolds are synthesized by sol-gel and hydrothermal methods, respectively with a Ca/P ratio of 1.67 and 20:80 (HA/PCL).The crystallization behavior and porosity of HA/PCL composite are studied by scanning electron microscope and X-Ray diffraction. The response of bone marrow-derived human mesenchymal stem cells (hMSCs) in terms of cell proliferation and differentiation to the osteoblastic... 

    Investigating Bio-Capability of HA-ZrO2-TiO2 Nano-Composite Coating by EPD on St. St 316 in Physiologic Solution

    , M.Sc. Thesis Sharif University of Technology Pourraeisi, Morteza (Author) ; Afshar, Abdollah (Supervisor)
    Abstract
    Metallic implants are useful in dental and orthopedic applications. Bio coating is necessary to improve bio-compatibility and bio-activation of metallic implants. For this goal, HA is the most important material. In this research, the goal is to improve bio-compatibility of St. St 316 by coating HA, HA-ZrO2, HA-TiO2, HA-ZrO2-TiO2 using combination of electrodeposition and electrophoretic methods. To form HA, calcium and phosphor salt solution was used then ZrO2- TiO2 nanoparticles was added to solution. In order to analyst the coatings different tests were done. Thickness analysis, XRD, FT-IR, FE-SEM and EDS, bonding Strength, Polarization test, bio-compatibility and surface roughness... 

    AC Anodizing of Pure Titanium Grade 2 with HA Nano Particle

    , M.Sc. Thesis Sharif University of Technology Chambary, Ehsan (Author) ; Ghorbani, Mohammad (Supervisor)
    Abstract
    In this study, biocompatible ceramic coating, containing hydroxyapatite particles (HA), was successfully created by AC anodizing, on the surface of commercially pure titanium grades 2. Coating process basically consisted of three methods. In Method 1, samples were anodized in a salty electrolyte containing calcium – phosphate base and in method 2 samples were anodized as initial process, following cathodic polarisation deposition of HA particles. Finally in method 3, samples were anodized in an electrolyte containing of HA particles suspension.Parameters such as current density and time of anodizing process, in first procedure, and time of cathodic deposition process in second procedure, and... 

    Synthesis of Composite Coating with HA Nanoparticles on Ti by AC Plasma Electrolyte Oxidation

    , M.Sc. Thesis Sharif University of Technology Soleymani Naeini, Masih (Author) ; Ghorbani, Mohammad (Supervisor)
    Abstract
    In this project, a ceramic biocompatible coating was applied on Titanium which is included Hydroxyapatite by AC Plasma Electrolyte Oxidation method. First, coating was performed in 5 different solutions and various duration in 500mA/Cm2 as a current density. Then, by microscopic and macroscopic images and size of porosity and also thickness of coat, 3 solutions were chosen for adding nanoparticles: Solution 1 which includes NaH2PO4 and Ca(CH3COO)2 , Solution 3 which includes Ca(CH3COO)2 and Na-Beta G and Solution 4 which includes Ca(H2PO4)2, HMP, NA2(EDTA) and Ca(CH3COO)2 . Also the time 10 minutes was chose as a appropriate time. The average of the porosities size in solution 1 was about... 

    Preparation and Characterization of Hydroxyapatite/Polycaprolactone Nanocomposites by Sol-gel Process

    , M.Sc. Thesis Sharif University of Technology Rezaei, Amirreza (Author) ; Mohammadi, Mohammad Reza (Supervisor)
    Abstract
    Hydroxyapatite (HA) is the most substantial mineral constituent of a bone which displays splendid biocompatibility and bioactivity properties. Nevertheless, its mechanical property is not utmost appropriate for a bone substitution. Therefore, a composite consist of HA and a biodegradable polymer is usually prepared to generate an apt bone scaffold. In the present work polycaprolactone (PCL), a newly remarkable biocompatible and biodegradable polymer, was employed as a matrix and hydroxyapatite nanoparticles and nanorods were used as a reinforcement element of the composite. HA/PCL nanocomposites were synthesized by three new in-situ sol-gel processes using a diverse range of phosphorus and... 

    Preparation and Characterisation of Titania-hydroxyapatite-carbon
    Nanotube Nanostructured Bioceramics by Sol-gel Process

    , M.Sc. Thesis Sharif University of Technology Majidnia, Elahe (Author) ; Mohammadi, Mohammad Reza (Supervisor)
    Abstract
    Hydroxyapatite (HA) is an attractive biomaterial due to its close chemical composition to bone and teeth. However, HA is brittle and has low strength under bearing loads, resulting in limition for orthopedic and dental applications. Two creative approaches have been developed to overcome this problem, using bioactive HA as coatings on metallic implants or as ceramic/metal composites. Carbon nanotubes (CNT) possess excellent mechanical properties to play the role as reinforcement for imparting strength and toughness to brittle hydroxyapatite (HA) bioceramic coating. Moreover, The addition of TiO2 to HA coatings has attracted considerable attention, since TiO2 is capable of increasing the...