Loading...

Preparation and Characterization of Chitosan-Gelatin/Polyanilne-Graphene-CNT Nanocomposite for Neural Tissue Engineering

Aein Jamshid, Mohammad | 2016

889 Viewed
  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51084 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Ramazani Saadatabadi, Ahmad
  7. Abstract:
  8. Repairing and regeneration of neural tissues have attracted considerable attention due to its direct effect on the quality of patients’ lives. Recent developments in nanotechnology and tissue engineering have facilitated their comprehensive applications in the treatment of neurological diseases, and several effective ways have been proposed to repair defects in neural tissues. The main objective of the researches in this field is to regulate cellular behavior and tissue progression through the design and development of synthetic extracellular matrices, such as novel biomaterials, that enhance cell culture and tissue regeneration. Natural polymers, such as chitosan and gelatin, are suitable options for the use in this field due to their biocompatibility and biodegradability. To regenerate neural tissues, scaffolds made of chitosan-gelatin hydrogels are required to be biocompatible and biodegradable, in addition to having high electrical properties and adequate mechanical properties. Introducing conductive polyaniline and carbon nanotubes (CNT) to the scaffolds enhance their mechanical properties and electrical conductivity. In this study, first, graphene oxide is synthesized using Hummers’ method and then, reduced to graphene. Next, conductive polyaniline is synthesized with an attempt to obtain the highest conductivity applying various synthesis conditions. The best result is polyaniline with the conductivity of 1.58 S.cm-1. For further enhancement of electrical conductivity, polyaniline/graphene nanocomposite is synthesized with the composition of 0.5wt% graphene. The polyaniline/graphene nanocomposite has the conductivity of 5.24 S.cm-1. Finally, chitosan/gelatin scaffolds containing different compositions of polyaniline/graphene and CNT are fabricated. High quantity of polyaniline/graphene and CNT jeopardizes the biocompatibility of the scaffold; therefore, the optimum composition is determined, assuring the highest possible biocompatibility along with the conductivity to be in the range required for neural tissue repairing
  9. Keywords:
  10. Conductive Polymer ; Biomaterials ; Tissue Engineering ; Nanobiocomposite ; Chitosan-Gelatin Blend ; Nerve Tissue Engineering ; Graphene-Carbon Nanotube Nanoparticles

 Digital Object List

 Bookmark

No TOC