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- Type of Document: M.Sc. Thesis
- Language: Farsi
- Document No: 51868 (06)
- Department: Chemical and Petroleum Engineering
- Advisor(s): Abdekhodaie, Mohammad Jafar; Seifkordi, Aliakbar; Ahmadieh, Hamid
- Abstract:
- In the present research the methods and challenges to ocular drug delivery have been investigated with more emphasis on ocular diseases that do not have any approved treatment. Periocular route is a promising alternative to the common routes of ocular drug delivery especially for treatment of posterior eye diseases. Based on barriers for efficient drug delivery to the eye, magnetic drug targeting revealed to be influential to eliminate some obstacles of this route which has not been worked before. It is hypothesized that the particles can pulled into the eye or will be trapped inside the sclera tissue or even if it is not happened, they can stay behind the sclera and magnetic force can prevent elimination of particles by bulk fluid flow which exists in the eye. To do this, particles that had both magnetic agent and drug were needed. Alginate was used as a biocompatible and bioadhesive polymer, Diclofenac Sodium as model drug and Iron Oxide nanoparticles as a biocompatible magnetic agent. Particles were prepared with four formulations and were characterized by different tests such as their shape, size, drug release rate and magnetic susceptibility. Finally, formulations named Particle 1 and Particle 4 were chosen with 417 and 60 nm in size respectively to test them with scleral tissue. The test was performed by human fresh sclera with diffusion cells that were designed for this special use. The rate of clearance of drug from the back of the eye was simulated in diffusion cell by pumping fresh PBS to the vessel. For comparison, the test was performed in the presence and absence of magnetic field. The results showed %24 and % 72 increases in the diffusion of drug in presence and absence of magnetic field for 417 and 60 nm particles, respectively. To determine the amount of particles that were trapped inside the tissue, the scleral Iron content was analyzed. The results showed three to four time increase in the amount of Iron content of sclera when the magnetic field was used. The results indicate that this method would be efficient in drug delivery to the posterior eye. This can be promising method for new treatments of eye diseases
- Keywords:
- Iron Oxide ; Alginate ; Ocular Drug Delivery ; Magnetic Drug Delivery ; Polymeric Drug Nanoparticles ; Targeted Druy Delivery
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