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Simulation and Study of Iso-Dose Curve for Asymmetrical Balloon in Balloon-Brachytherapy with Cs-131

Mohebbi Kojidi, Mohammad Hossein | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52480 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Hosseini, Abolfazl; Shirmardi, Pejman
  7. Abstract:
  8. Incidence of brain metastases (BM) from any tumor varies according to the method of data collection and date reported, ranging from 8 to 14 per 100,000 people per year. According to current population, about 6400 to 11000 BM Patients per year is expected. Without treatment, prognosis is dismal with survival of only 1–2 months. However, survival can be extended to 3–6 months with whole-brain radiotherapy (WBRT) and to 11 months with either surgery followed by adjuvant WBRT or surgery plus adjuvant stereotactic radiosurgery (SRS). Intravascular brachytherapy (generally iodine-125 (125I)) into the surgical cavity is another treatment strategy. 125I has been shown to confer local control comparable to that of postoperative SRS and WBRT, the rates of radiation necrosis have been criticized. A novel radioisotope, 131Cs confers both physical and radiobiological advantages over postoperative SRS and 125I brachytherapy.In this project, the goal is achieving isodose curves using MCNP Code for an asymmetrical (similar to resection cavity) balloon having with same tumor volume needed for balloon brachytherapy. Patient detail is extracted from medical images (such as MRI or CT Scan) by importing DICOM data in MIMICS Medical 21.0 software. The tumor volume and position imported in VIP phantom in next step. According to treatment plan at the tumor margin (irregular balloon) the required activity will be calculated and final isodose curves will be superimposed on a medical image and the treatment plan will be approved or rejected by doctor.Brachytherapy with an irregular balloon gives a more uniform dose distribution than a regular balloon. using 131Cs for radiotherapy makes treatment duration lower and isodose curves more uniform compared to 125I. the accuracy of this method depends on the geometry and should be applied per case.This method is suitable for obtaining isodose curves required in brachytherapy for some tumors with irregular geometry
  9. Keywords:
  10. Monte Carlo N-Particle Extended ; Isodose Curves ; Brachytherapy ; Lung Cancer ; Breast Cancer ; Metastasis ; Cesium-131

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