Sharif Digital Repository

Over the past few decades, brachytherapy has been used as one of the leading methods in the treatment of a wide range of cancers, including breast cancer. Due to the high dose gradient of brachytherapy radiation sources, this method is used to treat such tumors that are grown at the vicinity of sensitive points or tissues of the body. Therefore, as irradiation get started by implanting radiation sources in the desired position, at the same time healthy tissue are also receiving the same dose as tumor tissues do Reducing healthy tissue dose along with increasing the dose of tumor tissue is one of the challenging topics that researchers are always looking for a solution. In the left breast... 

The increasing advancement of computed tomography (CT) systems has led to the recognition of this type of imaging as an accurate and reliable method in diagnosing and assessing damage to humans and materials. Adding dual energy imaging to these systems can increase the material's ability to differentiate in this system and provide higher contrast than usual. Recently, a medical imaging technique has been introduced that uses an X-ray tube and two detector layers on top of each other, each layer absorbing a different energy spectrum.dual layer computed tomography system has been introduced today as a suitable tool for evaluating and diagnosing many diseases, due to the reliability and... 

Prostate cancer is the second most common cancer in men and the fourth most common cancer in all cancers. Cancer treatment is done according to the type of cancer and its diagnosis stage with different treatment methods and plans. Brachytherapy is one of the most common methods of cancer treatment along with teletherapy, surgery and chemotherapy. In this method, the source of radiation is located near or inside the tumor, and its advantage is to achieve a lower dose ratio of healthy tissue to the tumor is lower compared to teletherapy. One of the challenges in brachytherapy is to prescribe the appropriate treatment plan for the patient, so that the maximum dose of sources reaches the... 

In this study, using the MCNPX computer code based on the Monte Carlo method, the properties of protection against gamma-rays of the glass system with the combination of (55-x)Bi2O3-15Pb3O4-20Al2O3-10ZnO-xTiO2 with certain concentrations (x= 0, 5, 10, 15, 20, 25, 30 and 35 mol percent) and in nano and micro dimensions by calculating several parameters related to photon attenuation such as half value layer (HVL), Tenth value layer (TVL), mean free range (MFP), mass attenuation coefficient (m), linear attenuation coefficient (l), effective atomic number (Zeff) and buildup factor (BF) for We investigated different energy levels in the range of 1500-100 keV. To verify the simulation results,... 

X-ray Computed Tomography (CT) is a widely used medical imaging technique that provides cross-sectional images by measuring the attenuation of X-rays in the body. However, the increasing use of CT has raised concerns about the potential long-term risks associated with radiation exposure. Various approaches have been proposed to reduce radiation dose, and one of the latest methods is sparse-view CT, which has gained popularity due to its lower challenges compared to other techniques. In sparse-view CT, data acquisition is restricted to specific angles, resulting in a significant reduction in radiation dose. However, this approach can introduce streak artifacts in the reconstructed images due... 

In Radiation Detection Systems applied in Spectroscopy and Imaging, if the rate of particle incidence with detector is high, the output pulses being stacked up on each other will be expected, which is known as “Pulse Pile-up”. Pulse pile-up might result in a serious disorder of energy and timing data expected from the pulses. In recent decades and after successful implementation of pile-up rejection methods on analog circuits, considering development and progression in the field of digital, different algorithms based on pileup correction methods have been developed to obtain all spectrum information, whether energy, rise time and recorded pulses. Such methods can be compared in different... 

The initial step in radiotherapy treatment planning involves delineating the clinical target volumes (CTVs) and organs at risk (OARs). However, manual contouring is a time-consuming, labor-intensive, and subjective process. This study explores the potential of utilizing convolutional neural networks (CNNs) as an automated segmentation tool and an alternative to manual delineation. 218 Computed Tomography (CT) scans were gathered from two local hospitals in Tehran and the Whole Abdominal Organ Dataset (WORD). We employed ResUNet, a variant of UNet, as well as the original UNet from the Medical Open Network for AI (MONAI), an open-source framework for Deep Learning (DL) in healthcare imaging,... 

Proton therapy is an advanced method of cancer treatment that has the ability to provide better protons than other radiation therapy methods. Even though the charged particles have superior characteristics and their biological properties are more than the deviations in treatment design. In order to check the uncertainties in hadron therapy and reduce the side risks, there is a need for methods to monitor the range during radiation therapy. Considering that the charged particles are in the tissue, the monitoring method should be able to collect the secondary particles produced during the interaction of the primary beam with the tissue. Currently, positron emission tomography (PET) is the only... 

Since the beginning of discussion on neutron-gamma discrimination, different methods were suggested for this purpose. In early 2000s, Analogue methods were mainly used to discriminate the spectrum in mixed fields which mostly depends on electronic modules used in the lab setup; Nowadays, with improvements in digital pulse processing techniques, analyzing mixed neutron-gamma fields for pulse discrimination is also available.In this research, the recent MC developed toolkit called GEANT4 is used to simulate the 3-inch BC501A scintillation detector and 500 mCi Am-Be source (that emits neutron and gamma at the same time). For the next step, an experiment with same source and detector was done... 

In the realm of cancer treatment through radiation therapy, a primary hurdle has long been the impact of radiation on adjacent healthy tissues during treatment of cancerous tissues. To address this challenge, FLASH Proton Therapy (FPT) emerges as a promising solution, with a high dose rate exceeding 40Gy/s. This research endeavor focuses on the development and validation of a Monte Carlo (MC) based model for FPT, with the aim of extending its applicability to human treatment plans. Initially, the Proton Therapy System (PTS) employing spot scanning was modeled using the GATE software. Subsequent simulations were conducted to determine dosimetric and optical characteristics of the proton beam... 

To study the structure of materials, among materials containing hydrogen, an instrument called the "small-angle neutron scattering instrument" is used. Having a monochromatic neutron beam is the most basic component of this instrument. This beam is often produced using a device called the "neutron velocity selector". The neutron velocity selector is a rotating mechanical piece that allows for passage of neutrons at a certain speed, according to its rotational speed. In fact, this device produces a monochromatic neutron beam with continuous flux. Until now, it has been designed and manufactured in a variety of models, which are generally divided into two groups of multi-disc and multi-blade... 

Positron emission tomography (PET) imaging is a cross-sectional imaging method in nuclear medicine. In recent years, there have been increasing interest in this method.PET imaging is very sensitive and the presence of noise in the results decreases the the image quality and precision of detection. Thus it is critical to to investigate noise in PET systems with noisy images, since it could decrease the system’s ability to detect tumors. The common method to decrease noise in nuclear medicine images is the Fourier transform (FT). The method has many applications in image processing and analysis. However, in the FT method, information regarding time and position are lost in the frequency... 

One of the ways to enhance the safety and economic performance of nuclear power plants, is to choose an appropriate policy for arrange the reactor fuel assembly in the beginning of each cycle. There are variety of ways to optimize the layout of the fuel in the reactor core, but to achieve more than one goal, choosing multi-objective method can be used.One of the intelligent optimization methods is the genetic algorithms that emulate nature of biological processes and can be used to optimize two or more of the target.The goals of this research is to increase the neutron multiplication factor is to make maximum use of the fuel in the reactor and maintain the radial power peaking factor for... 

Conventional MRI has been used to diagnose different types of brain injuries. However these methods have generally failed to diagnose mild types of injury. We are working on the specification of mild traumatic brain injury, using diffusion MRI data, based on a multi compartment simulation of white matter tissue. This effort is essential for better understanding of underlying tissue micro-structure changes in patients with trauma. Some studies have been used in similar data fitting approaches in order to estimate axon diameter distribution. Specifically, a comparative study between different Compartment Models has shown that “ActiveAx” model has the best agreement with underlying tissue... 

The present M.Sc. thesis consists of two sections including the static calculation and neutron noise calculation in rectangular and hexagonal geometries. The multi-group, two dimensional neutron diffusion equations and corresponding adjoint equations are solved in the static calculation. The spatial discretization of equations is based on Average Current Nodal Expansion Method (ACNEM). Size of nodes is the same size of the fuel assemblies in modeling both of rectangular and hexagonal geometries. The results are benchmarked against the valid results for BIBLIS-2D and IAEA-2D benchmark problems. In the second section, neutron noise calculations are performed for two types of noise sources,... 

Since direct measurement of neutron energy, unlike measuring the energy of ionizing radiation, is difficult, and the use of indirect methods for detecting and measuring neutron energy with high resolution and acceptable efficiency are not possible, the neutron time of flight method is the only direct neutron energy spectroscopy method. This issue is considered and evaluated in two methods: direct and scattering neutron time of flight. For this purpose, we have considered the 241Am-9Be source. In this method, neutron velocity can be determined by measuring time. is the time for the neutron that travels at distance of . The next method is the dispersed neutron time of flight method, in... 

The Electron Paramagnetic Resonance(EPR) is a retrospective and accurate dosimetry method to measure irradiated-induced radical population in the matter for determination the induced dose in the matter. The dose uncertainties will be about 1 percent. in the first stage of the present research, the response of EPR system to a reference sample has been measured. Then, responses due to the other samples has been compared with it and the secondary sample dose has been calculated. The reference sample usually is alanine. Unlike the perturbation theory forecast,the EPR signal intensity response to dose for alanine is not linear. In this thesis, first, the alanine samples (with pellet form) have... 

Validation of dosimetry accuracy in the context of advanced methods for radiotherapy, including proton therapy for ensure the accuracy of treatment plan is nessecory. One of the reasons for using MC code is the modeling of PT systems and the support of more accurate computation of dose distribution in clinical tarin. The purpose of this project is to validate the modeling of a spot scanning proton therapy system using a GATE MC code. In this study, the dose distribution calculated in the calibration process of the device and syno TPS is used as a criterion and the dose distribution obtained from the GATE MC code is calculated and validated with it. For this purpose, a water phantom was used... 

Neutron Radiography is one of the non-destructive testing methods of materials and due to its special application compared to gamma or X-ray imaging, it is highly regarded and developed in the world. A special application of neutron imaging is the imaging of materials with a low atomic number, even when coated with a material with a high atomic number. Neutron Radiography has different methods for capturing and recording images by neutrons. Among these methods, the following 7 methods can be mentioned: Neutron radiography (film), Track Etch, Digital neutron imaging, Neutron camera (DR System), Image plates (CR System), Flat panel silicon detectors (DR system) and Micro channel plates (DR... 

Following dramatic changes after using deep learning method as a solution for Natural Language Processing tasks, Transformer architecture get popular. Based on that, then BERT Language model presented and get state-of-the-art as a solution for a lot of language processing tasks. It was a turning point in Natural Language Processing field. Also, in cross-lingual methods research line motivated by developing a common space for representation of language units, e.g. words, sentences, in more that one language, get some remarkable improvements. However, for languages distant from English such as Persian or Arabic the methods' performance was not clear. In this work, we performed some innovative...