Analysis and Evaluation of Heterogeneous Diffusion Model in Accordance with DWI Data

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Vafaei, Amin | 2017

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Type of Document: M.Sc. Thesis
Language: Farsi
Document No: 49948 (46)
University: Sharif University of Technology
Department: Energy Engineering
Advisor(s): Hosseini, Abolfazl; Jahed, Mehran
Abstract:
Conventional MRI has been used to diagnose different types of brain injuries. However these methods have generally failed to diagnose mild types of injury. We are working on the specification of mild traumatic brain injury, using diffusion MRI data, based on a multi compartment simulation of white matter tissue. This effort is essential for better understanding of underlying tissue micro-structure changes in patients with trauma. Some studies have been used in similar data fitting approaches in order to estimate axon diameter distribution. Specifically, a comparative study between different Compartment Models has shown that “ActiveAx” model has the best agreement with underlying tissue structure. The proposed approach is based on the knowledge that traumatic brain injury can affect axons geometry, namely shearing, swelling and disruption as these changes in geometry influence axon diameter distribution. Based on this observation we were able to ascertain the disrupted area by studying the suspected distributions
Keywords:
Magnetic Resonance Imagin (MRI) ; Microstructure ; Molecular Diffusion ; Diffusion Weighted Imaging (DWI) ; Brain Damage ; Axons Diameter ; Tissue Model

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