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Kineticts of formation of Titania Nanotubes and Silk Fibroin on Titanium-based Metal for Investigating the Drug Release Behavior

Goudarzi, Arghavan | 2018

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 52522 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Sadrnezhad, Khatiboleslam
  7. Abstract:
  8. In recent decades, due to the significant growth of implants’ application and considering the infection of the implants as the most momentous factor in implantation failure, study on the controlled drug release and other biologically active agents in modern drug delivery systems has attracted many kinds of research throughout the world and efforts are being made to use regulated drug delivery systems for implantation which is also the purpose of this current scientific work.To achieve this, the anodizing process was used to fabricate titanium oxide nanotubes (TNTs) to increase the absorption capacity of the drug in the implants and these TNTs were formed regularly and uniformly in an organic electrolyte solution at 15-17 ºC in 2 hours at the voltage of 60 volts. In the next step, the drug loading process was accomplished using a vacuum system. Subsequently, the electrospinning operation was utilized to produce the nanofibers given the fact that silk fibroin nanofibers can establish the appropriate connection with TNTs and have the ability to improve the controlled release. Due to the number of variables in the electrospinning machine, to obtain the suitable nanofibers production conditions with acceptable morphology, an experimental design was carried out.Finally, it was found out that the concentration of the polymeric solution plays the most important role in the electrospinning process and is more effective than the device parameters. Then, topographic and surface roughness tests were performed by atomic force microscopy (AFM). The results showed an increase in the surface roughness which resulted in improved cellular properties and cellular adhesion.To evaluate the drug release behavior from the samples, the UV-Vis spectroscopy was accomplished, and the obtained results exhibited that the samples having coating had a much more controlled drug release (sustained manner) than the uncoated sample and the drug release time in these samples also increased dramatically
  9. Keywords:
  10. Anodizing ; Silk Fibroin ; Electrospinning ; Drug Delivery ; Controlled Release ; Vancomycin Antibiotic ; Titania Nanotubes

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