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Model Predictive Inferential Control for Electrochemotherapy of Tumors

Valibeknejhad, Mohammad | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53160 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Pishvaie, Mahmoud Reza
  7. Abstract:
  8. The purpose of this project is to use adaptive model predictive and fuzzy controllers to control the pH in a proper location and right amount as well as applying optimal dose of electrical current to prevent the destruction of healthy tissue during treatment. Comsol software has been used to simulate the electrochemical treatment of liver cancer. Since the Comsol software does not have the ability to solve the tumor model in spherical coordinates, the modeling/simulation was performed in cylindrical ordinates. In this study, only the reactions of oxygen and chlorine production in the anode were considered. The predictive control used in this study is GPC type and fmincon algorithm is used for optimization. Predictive control was designed as fixed and adaptive. In order to design fixed controller, a second-order model has been identified, and the recursive least squares identification algorithm is used in the adaptive mode. The proposed controller was able to bring the pH of the domain around the anode to a setpoint value. Then a fuzzy controller was designed to control pH using tracking error and tracking error changes. The proposed controller is Mamdani type and contains 21 fuzzy rules. The designed fuzzy controller was able to bring the pH to the setpoint value. Additionally, in order to reduce the number of pH measurements, the applied Coulomb value was considered as an input of the fuzzy controller. The designed controller succeeded in bringing the pH to the preset value by measuring the pH at one point in the tumor domain
  9. Keywords:
  10. Fuzzy Control ; Adaptive Generalized Predictive Control ; Electrochemical Treatment ; System Identification ; Computational-Electrochemical Transport Phenomenon ; Tumors ; Cancer Treatment

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