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Improvement of size-based particle separation throughput in slanted spiral microchannel by modifying outlet geometry

Mihandoust, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1002/elps.201900436
  3. Publisher: Wiley-VCH Verlag , 2020
  4. Abstract:
  5. The inertial microfluidic technique, as a powerful new tool for accurate cell/particle separation based on the hydrodynamic phenomenon, has drawn considerable interest in recent years. Despite numerous microfluidic techniques of particle separation, there are few articles in the literature on separation techniques addressing external outlet geometry to increase the throughput efficiency and purity. In this work, we report on a spiral inertial microfluidic device with high efficiency (>98%). Herein, we demonstrate how changing the outlet geometry can improve the particle separation throughput. We present a complete separation of 4 and 6 μm from 10 μm particles potentially applicable to separate microalgae (Tetraselmis suecica from Phaeodactylum tricornutum). Two spiral microchannels with the same cross section dimension but different outlet geometry were considered and tested to investigate the particle focusing behavior and separation efficiency. As compared with particle focusing observed in channels with a simple outlet, the particle focusing in a modified outlet geometry appears in a more successful focusing manner with complete separation. This simple approach of particle separation makes it attractive for lab-on-a-chip devices for continuous extraction and filtration of a wide range of cell/particle sizes. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
  6. Keywords:
  7. Inertial microfluidics ; Low-cost fabrication ; Outlet geometry ; Particle separation ; Flow rate ; Geometry ; High throughput analysis ; Hydrodynamics ; Microfluidics ; Microtechnology ; Nonhuman ; Particle size ; Phaeodactylum tricornutum ; Separation technique ; Tetraselmis ; Tetraselmis suecica ; Extraction ; Filtration ; Microalga
  8. Source: Electrophoresis ; Volume 41, Issue 5-6 , February , 2020 , Pages 353-359
  9. URL: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/elps.201900436