Synthesis and Characterization of Polymeric Nanocomposites Via Reversible Addition−Fragmentation Chain-Transfer (RAFT) Polymerization and Investigation of their Applications

Kohestanian, Mohammad | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54396 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Pourjavadi, Ali
  7. Abstract:
  8. In this thesis, nanocomposites based on magnetic graphene oxide and iron oxide nanoparticles coated with smart polymeric materials (by polymerization of monomers such as glycidyl methacrylate, acrylic acid, and N-isopropyl acrylamide) via Reversible Addition−Fragmentation Chain-Transfer (RAFT) polymerization were successfully synthesized. The combination of large surface area in nanoparticles and different functional groups in polymeric layers can give unique properties to nanocomposites. Therefore, we synthesized various smart nanocomposites with this perspective. After synthesizing these nanocomposites, smart magnetic nanoparticles were characterized by FT-IR, NMR, XPS, TGA, DLS, VSM, GPC, TEM, and XRD analysis. Then, the prepared nanocomposites were used as multi-responsive nanocarriers in drug delivery purposes. The presence of different functional groups in the structure of the prepared composites by forming various chemical, electrostatic, and hydrogen bonds help to adsorb doxorubicin on the surface of nanocarriers. Finally, the in-vitro drug release of doxorubicin for synthesized nanocarriers was examined in various conditions (pH and temperature), and the results established excellent pH and thermal dependence. Also, in all nanocomposites, polymer chains were attached to the surface of nanoparticles with chemical bonds. By mixing of good properties of different nanoparticles (iron oxide and graphene oxide), and polymeric materials, we can achieve high-performance nanomaterials. The effect of various factors such as pH, temperature, the molecular weight of living polymer (dormant) on drug adsorption capacity and release in the synthesized nanocarriers was investigated. Also, the effect of molecular weight of living polymers on the properties of the prepared nanocomposites was investigated and it was found that the molecular weight of the living polymer can affect the final properties of the nanocomposites. Furthermore, the drug release results revealed good temperature and pH sensitivity for the prepared nanocomposites. Therefore, experimental data and results showed that nanocarriers synthesized by RAFT polymerization could be deployed for practical biomedicine applications
  9. Keywords:
  10. Magnetic Nanocomposite ; Doxorubicin ; Drug Delivery ; Reversible Addition-Fragmentation Chain-Transfer (RAFT) ; Polymerization ; Drug Release

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