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Synthesis, Characterization and Application of Inorganic Nanosystems based on Biocompatible and Highly Tunable Materials for Targeted Delivery and Release of Gene and Drug

Rabiee, Navid | 2021

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  1. Type of Document: Ph.D. Dissertation
  2. Language: Farsi
  3. Document No: 54425 (03)
  4. University: Sharif University of Technology
  5. Department: Chemistry
  6. Advisor(s): Bagherzadeh, Mojtaba
  7. Abstract:
  8. In this dissertation, an attempt has been made to prepare a library from most of the inorganic and organic compounds in order to strengthen the use of nanosystems for the purpose of controlled delivery and release of drugs and genetic material. In this regard, a complete set of compounds based on metal nanoparticles, layered double hydroxides, metal-organic frameworks, graphene oxide and carbon nanotubes were designed, synthesized and characterized, and nanocomposites and hybrids of them based on palladium, zinc, copper and nickel were designed as well. The nano-stable system is designed with positive surface potential, very low cytotoxicity, biodegradability and acceptable environment as well as cellular sensitivity. All of these compounds have been designed, synthesized, and characterized according to principles that are designed to maximize the use of genetically engineered cargo delivery and controlled release based on the nanosystems, and it is necessary to be aware of these principles as well. To this end, general principles for selecting the nanosystems for these biomedical applications were studied and optimized based on zeta potential, particle size, potential cytotoxicity, drug delivery and genetic material delivery mechanism, as well as the all-use mechanisms between nanocarrier, drug and genetic material and the ratio of natural materials including plant and fruit extracts to synthetic materials along with the nanocarrier morphology. Finally, an attempt has been made to use the designed nanosystems for the purpose of controlled delivery and release of drug (doxorubicin) and genetic material (plasmid CRISPR) with a green approach, cost-effective methods, acceptable repeatability and in accordance with the principles of clinical trials
  9. Keywords:
  10. Targeted Druy Delivery ; Targeted Gene Delivery ; Organic-Inorganic Hybrid Nanosystems ; Inorganic Nanosystem ; Biocompatibility ; Controlled Release ; Doxorubicin

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