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Simulation of Active Proton Therapy Scanning System with GATE Simulator in Order to Reduce the Dose Reached to the Patient

Asadi, Ali | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54491 (46)
  4. University: Sharif University of Technology
  5. Department: Energy Engineering
  6. Advisor(s): Hosseini, Abolfazl; Vosoughi, Naser
  7. Abstract:
  8. Validation of dosimetry accuracy in the context of advanced methods for radiotherapy, including proton therapy for ensure the accuracy of treatment plan is nessecory. One of the reasons for using MC code is the modeling of PT systems and the support of more accurate computation of dose distribution in clinical tarin. The purpose of this project is to validate the modeling of a spot scanning proton therapy system using a GATE MC code. In this study, the dose distribution calculated in the calibration process of the device and syno TPS is used as a criterion and the dose distribution obtained from the GATE MC code is calculated and validated with it. For this purpose, a water phantom was used and optical and beam dosimetry parameter obtained from MC cose. In an additional step, fabrication modeling was performed to validate the required parameters in proton dosimetry, such as range, half-maximum width, Bragg peak expansion area, longitudinal and transverse dose profiles to validate energy efficiency 130.1-235 MeV was considered. The validation of the beam model was performed by comparing the measured relative dose distributions and the dose distributions obtained from the simulations with GATE, using the programming specifications of the device for the performance and energy of the beam point. The results of MC simulations showed unique depth dose measurements and peak development plans for good success. The absolute comparison of the absorbed dose difference between MC and the exp was ± 1%. The results of prostate treatment modeling treatment showed a good relationship between the data from the simulation versus the TPS with a difference of less than 5% in the cases examined. Therefore, Monte Carlo modeling is a good criterion for evaluating dosimetric calculations in the patient's body
  9. Keywords:
  10. Proton Therapy ; Monte Carlo Model ; Prostate ; Geant4 Application for Tomographic (GATE)Emission ; Active Sccaning ; Radiotherapy ; Dosimetry Calculations

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